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Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)

 SHPS1_MOUSE             Reviewed;         513 AA.
P97797; A0A0R4J1Z7; E0CYM8; E9QPT7; O08907; O35924; O88555; O88556; P97796;
Q8R559; Q9QX57; Q9WTN4;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
08-MAY-2019, sequence version 2.
07-APR-2021, entry version 186.
RecName: Full=Tyrosine-protein phosphatase non-receptor type substrate 1;
Short=SHP substrate 1;
Short=SHPS-1;
AltName: Full=Brain Ig-like molecule with tyrosine-based activation motifs;
Short=Bit;
AltName: Full=CD172 antigen-like family member A;
AltName: Full=Inhibitory receptor SHPS-1;
AltName: Full=MyD-1 antigen;
AltName: Full=Signal-regulatory protein alpha-1;
Short=Sirp-alpha-1;
Short=mSIRP-alpha1;
AltName: Full=p84;
AltName: CD_antigen=CD172a;
Flags: Precursor;
Name=Sirpa; Synonyms=Bit, Myd1, Ptpns1, Shps1, Sirp;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Brain;
PubMed=9070220; DOI=10.1006/bbrc.1996.6047;
Yamao T., Matozaki T., Amano K., Matsuda Y., Takahashi N., Ochi F.,
Fujioka Y., Kasuga M.;
"Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal
localization of genes.";
Biochem. Biophys. Res. Commun. 231:61-67(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
STRAIN=BALB/cJ; TISSUE=Brain;
PubMed=9073522; DOI=10.1006/geno.1996.4581;
Ohnishi H., Kubota M., Sano S.;
"BIT (Bit) maps to mouse chromosome 2.";
Genomics 40:504-506(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), PROTEIN SEQUENCE OF 32-53
AND 422-433 (ISOFORM 2), GLYCOSYLATION, AND TISSUE SPECIFICITY.
STRAIN=BALB/cJ; TISSUE=Brain, and Cerebellum;
PubMed=9348339; DOI=10.1523/jneurosci.17-22-08702.1997;
Comu S., Weng W., Olinsky S., Ishwad P., Mi Z., Hempel J., Watkins S.,
Lagenaur C.F., Narayanan V.;
"The murine P84 neural adhesion molecule is SHPS-1, a member of the
phosphatase-binding protein family.";
J. Neurosci. 17:8702-8710(1997).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), GLYCOSYLATION,
PHOSPHORYLATION AT TYROSINE RESIDUES, INTERACTION WITH PTPN6, AND TISSUE
SPECIFICITY.
STRAIN=C57BL/6J; TISSUE=Fetal thymus;
PubMed=9712903; DOI=10.1074/jbc.273.35.22719;
Veillette A., Thibaudeau E., Latour S.;
"High expression of inhibitory receptor SHPS-1 and its association with
protein tyrosine phosphatase SHP-1 in macrophages.";
J. Biol. Chem. 273:22719-22728(1998).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3), AND
GLYCOSYLATION.
STRAIN=129/SvJ, and C57BL/6J; TISSUE=Brain, and Liver;
PubMed=10585853; DOI=10.1042/bj3440667;
Sano S., Ohnishi H., Kubota M.;
"Gene structure of mouse BIT/SHPS-1.";
Biochem. J. 344:667-675(1999).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
STRAIN=ILS, and ISS;
PubMed=11471062; DOI=10.1007/s00335-001-1001-x;
Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J.,
Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.;
"High-throughput sequence identification of gene coding variants within
alcohol-related QTLs.";
Mamm. Genome 12:657-663(2001).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
TISSUE=Placenta;
Wang H., Chen Z., Ullrich A.;
"Epidermal growth factor-induced association of SHP2 with mouse SIRP-
alpha1.";
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[10]
FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=2303162; DOI=10.1016/0012-1606(90)90249-i;
Chuang W., Lagenaur C.F.;
"Central nervous system antigen P84 can serve as a substrate for neurite
outgrowth.";
Dev. Biol. 137:219-232(1990).
[11]
GLYCOSYLATION, PHOSPHORYLATION BY JAK2 IN RESPONSE TO GROWTH HORMONE, AND
INTERACTION WITH JAK2 AND PTPN11.
PubMed=9507023; DOI=10.1074/jbc.273.12.7112;
Stofega M.R., Wang H., Ullrich A., Carter-Su C.;
"Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and
association.";
J. Biol. Chem. 273:7112-7117(1998).
[12]
INTERACTION WITH CD47, AND TISSUE SPECIFICITY.
PubMed=9872987; DOI=10.1074/jbc.274.2.559;
Jiang P., Lagenaur C.F., Narayanan V.;
"Integrin-associated protein is a ligand for the P84 neural adhesion
molecule.";
J. Biol. Chem. 274:559-562(1999).
[13]
INTERACTION WITH FGR.
PubMed=10662797; DOI=10.1084/jem.191.3.515;
Gresham H.D., Dale B.M., Potter J.W., Chang P.W., Vines C.M., Lowell C.A.,
Lagenaur C.F., Willman C.L.;
"Negative regulation of phagocytosis in murine macrophages by the Src
kinase family member, Fgr.";
J. Exp. Med. 191:515-528(2000).
[14]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-246.
STRAIN=C57BL/6J; TISSUE=Plasma;
PubMed=16944957; DOI=10.1021/pr060186m;
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.;
"Proteome-wide characterization of N-glycosylation events by diagonal
chromatography.";
J. Proteome Res. 5:2438-2447(2006).
[15]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=18034455; DOI=10.1021/pr0701254;
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine
phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
[16]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[17]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Heart, Kidney, Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as
docking protein and induces translocation of PTPN6, PTPN11 and other
binding partners from the cytosol to the plasma membrane. Supports
adhesion of cerebellar neurons, neurite outgrowth and glial cell
attachment. May play a key role in intracellular signaling during
synaptogenesis and in synaptic function. Involved in the negative
regulation of receptor tyrosine kinase-coupled cellular responses
induced by cell adhesion, growth factors or insulin. Mediates negative
regulation of phagocytosis, mast cell activation and dendritic cell
activation. CD47 binding prevents maturation of immature dendritic
cells and inhibits cytokine production by mature dendritic cells (By
similarity). {ECO:0000250, ECO:0000269|PubMed:2303162}.
-!- SUBUNIT: Binds PTPN11 when tyrosine-phosphorylated, except in
macrophages, where it primarily binds PTPN6. Binds GRB2 vitro. Binds
FGR. Binds JAK2 irrespective of its phosphorylation status and forms a
stable complex. Binds SCAP1 and/or SCAP2. The resulting complex
recruits FYB1. Binds PTK2B (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Comment=Additional isoforms seem to exist.;
Name=1; Synonyms=a;
IsoId=P97797-1; Sequence=Displayed;
Name=2; Synonyms=a', Large;
IsoId=P97797-2; Sequence=VSP_007032;
Name=3; Synonyms=b, Small;
IsoId=P97797-3; Sequence=VSP_007031;
Name=4;
IsoId=P97797-4; Sequence=VSP_007031, VSP_007032;
-!- TISSUE SPECIFICITY: Highly expressed in cerebral cortex, brain, spinal
cord, cerebellum and spleen, and at much lower levels in kidney,
thymus, heart, lung and liver. Within the cerebellum, highly expressed
throughout the molecular layer, and in synaptic glomeruli in the
granule cell layer. Detected in neurons of the hippocampus and dentate
gyrus, and in olfactory bulb. Not detected in Purkinje cells. Highly
expressed in the plexiform layers, optic fiber layer and the outer
segments of the photoreceptor layer in the retina. Highly expressed in
macrophages. Isoform 3 is detected at very low levels in all tissues
tested. {ECO:0000269|PubMed:2303162, ECO:0000269|PubMed:9348339,
ECO:0000269|PubMed:9712903, ECO:0000269|PubMed:9872987}.
-!- DEVELOPMENTAL STAGE: Highly expressed in the CNS of embryos from day 7
to 17. {ECO:0000269|PubMed:2303162}.
-!- PTM: N-glycosylated. {ECO:0000269|PubMed:10585853,
ECO:0000269|PubMed:16944957, ECO:0000269|PubMed:9348339,
ECO:0000269|PubMed:9507023, ECO:0000269|PubMed:9712903}.
-!- PTM: Phosphorylated on tyrosine residues. {ECO:0000269|PubMed:9507023,
ECO:0000269|PubMed:9712903}.
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EMBL; D87967; BAA13520.1; -; mRNA.
EMBL; D87968; BAA13521.1; -; mRNA.
EMBL; D85785; BAA20376.1; -; mRNA.
EMBL; U89694; AAB92591.1; -; mRNA.
EMBL; AF072543; AAC24886.1; -; mRNA.
EMBL; AF072544; AAC24887.1; -; mRNA.
EMBL; AB024507; BAA89290.1; -; Genomic_DNA.
EMBL; AB018194; BAA76555.1; -; mRNA.
EMBL; AB024507; BAA89289.1; -; Genomic_DNA.
EMBL; AF332079; AAK56107.1; -; mRNA.
EMBL; AF332080; AAK56108.1; -; mRNA.
EMBL; Y10349; CAA71375.1; -; mRNA.
EMBL; AL808126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH466519; EDL28242.1; -; Genomic_DNA.
CCDS; CCDS16729.1; -. [P97797-2]
CCDS; CCDS50708.1; -. [P97797-4]
CCDS; CCDS71142.1; -. [P97797-1]
CCDS; CCDS71143.1; -. [P97797-3]
PIR; JC5288; JC5288.
PIR; JC5289; JC5289.
RefSeq; NP_001171118.1; NM_001177647.2. [P97797-4]
RefSeq; NP_001277948.1; NM_001291019.1. [P97797-1]
RefSeq; NP_001277949.1; NM_001291020.1. [P97797-1]
RefSeq; NP_001277950.1; NM_001291021.1. [P97797-3]
RefSeq; NP_031573.2; NM_007547.4. [P97797-2]
RefSeq; XP_006499049.1; XM_006498986.3. [P97797-1]
RefSeq; XP_017172050.1; XM_017316561.1.
RefSeq; XP_017172057.1; XM_017316568.1. [P97797-3]
RefSeq; XP_017172058.1; XM_017316569.1. [P97797-4]
PDB; 2YZ1; X-ray; 1.40 A; A/B=32-146.
PDBsum; 2YZ1; -.
SMR; P97797; -.
BioGRID; 202490; 11.
CORUM; P97797; -.
IntAct; P97797; 5.
MINT; P97797; -.
STRING; 10090.ENSMUSP00000099491; -.
GlyConnect; 2714; 29 N-Linked glycans (13 sites).
GlyGen; P97797; 17 sites.
iPTMnet; P97797; -.
PhosphoSitePlus; P97797; -.
jPOST; P97797; -.
MaxQB; P97797; -.
PaxDb; P97797; -.
PeptideAtlas; P97797; -.
PRIDE; P97797; -.
ProteomicsDB; 261353; -. [P97797-1]
ProteomicsDB; 261354; -. [P97797-2]
ProteomicsDB; 261355; -. [P97797-3]
ProteomicsDB; 328968; -.
ProteomicsDB; 339176; -.
ProteomicsDB; 367856; -.
ABCD; P97797; 27 sequenced antibodies.
Ensembl; ENSMUST00000049262; ENSMUSP00000049022; ENSMUSG00000037902. [P97797-1]
Ensembl; ENSMUST00000099113; ENSMUSP00000096713; ENSMUSG00000037902. [P97797-3]
Ensembl; ENSMUST00000103202; ENSMUSP00000099491; ENSMUSG00000037902. [P97797-2]
Ensembl; ENSMUST00000103203; ENSMUSP00000099492; ENSMUSG00000037902. [P97797-2]
Ensembl; ENSMUST00000160276; ENSMUSP00000125004; ENSMUSG00000037902. [P97797-4]
Ensembl; ENSMUST00000161620; ENSMUSP00000124048; ENSMUSG00000037902. [P97797-1]
Ensembl; ENSMUST00000179001; ENSMUSP00000137611; ENSMUSG00000037902. [P97797-2]
GeneID; 19261; -.
KEGG; mmu:19261; -.
UCSC; uc008mhz.1; mouse.
CTD; 140885; -.
MGI; MGI:108563; Sirpa.
eggNOG; ENOG502S1XD; Eukaryota.
GeneTree; ENSGT00960000186656; -.
HOGENOM; CLU_1106792_0_0_1; -.
InParanoid; P97797; -.
OMA; TEYASIR; -.
OrthoDB; 904196at2759; -.
PhylomeDB; P97797; -.
Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
Reactome; R-MMU-2172127; DAP12 interactions.
Reactome; R-MMU-391160; Signal regulatory protein family interactions.
Reactome; R-MMU-6798695; Neutrophil degranulation.
BioGRID-ORCS; 19261; 0 hits in 53 CRISPR screens.
ChiTaRS; Sirpa; mouse.
EvolutionaryTrace; P97797; -.
PRO; PR:P97797; -.
Proteomes; UP000000589; Chromosome 2.
RNAct; P97797; protein.
Bgee; ENSMUSG00000037902; Expressed in stroma of bone marrow and 311 other tissues.
ExpressionAtlas; P97797; baseline and differential.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0098632; F:cell-cell adhesion mediator activity; ISO:MGI.
GO; GO:0030695; F:GTPase regulator activity; ISO:MGI.
GO; GO:1990405; F:protein antigen binding; ISO:MGI.
GO; GO:0086080; F:protein binding involved in heterotypic cell-cell adhesion; ISO:MGI.
GO; GO:0019903; F:protein phosphatase binding; IPI:ARUK-UCL.
GO; GO:0045309; F:protein phosphorylated amino acid binding; IPI:MGI.
GO; GO:1990782; F:protein tyrosine kinase binding; ISO:MGI.
GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO; GO:0007015; P:actin filament organization; IMP:MGI.
GO; GO:0016477; P:cell migration; ISO:MGI.
GO; GO:0007160; P:cell-matrix adhesion; IMP:MGI.
GO; GO:0070301; P:cellular response to hydrogen peroxide; ISO:MGI.
GO; GO:0071346; P:cellular response to interferon-gamma; ISO:MGI.
GO; GO:0071347; P:cellular response to interleukin-1; ISO:MGI.
GO; GO:0071349; P:cellular response to interleukin-12; ISO:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:ARUK-UCL.
GO; GO:0007010; P:cytoskeleton organization; IMP:MGI.
GO; GO:0097530; P:granulocyte migration; IGI:ARUK-UCL.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
GO; GO:0035696; P:monocyte extravasation; ISO:MGI.
GO; GO:0071650; P:negative regulation of chemokine (C-C motif) ligand 5 production; IMP:ARUK-UCL.
GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IMP:ARUK-UCL.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:ARUK-UCL.
GO; GO:1903720; P:negative regulation of I-kappaB phosphorylation; IMP:ARUK-UCL.
GO; GO:0050728; P:negative regulation of inflammatory response; ISO:MGI.
GO; GO:0032688; P:negative regulation of interferon-beta production; IMP:ARUK-UCL.
GO; GO:0032715; P:negative regulation of interleukin-6 production; IMP:ARUK-UCL.
GO; GO:0046329; P:negative regulation of JNK cascade; IMP:ARUK-UCL.
GO; GO:0071641; P:negative regulation of macrophage inflammatory protein 1 alpha production; IMP:ARUK-UCL.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IMP:ARUK-UCL.
GO; GO:0050765; P:negative regulation of phagocytosis; IMP:ARUK-UCL.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IMP:ARUK-UCL.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IMP:ARUK-UCL.
GO; GO:0006911; P:phagocytosis, engulfment; IDA:MGI.
GO; GO:0006910; P:phagocytosis, recognition; IDA:MGI.
GO; GO:0050766; P:positive regulation of phagocytosis; IDA:MGI.
GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
GO; GO:0010468; P:regulation of gene expression; ISO:MGI.
GO; GO:0032649; P:regulation of interferon-gamma production; ISO:MGI.
GO; GO:0032651; P:regulation of interleukin-1 beta production; ISO:MGI.
GO; GO:0032675; P:regulation of interleukin-6 production; ISO:MGI.
GO; GO:0045428; P:regulation of nitric oxide biosynthetic process; ISO:MGI.
GO; GO:0032680; P:regulation of tumor necrosis factor production; ISO:MGI.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003006; Ig/MHC_CS.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07654; C1-set; 2.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 2.
SMART; SM00407; IGc1; 2.
SUPFAM; SSF48726; SSF48726; 3.
PROSITE; PS50835; IG_LIKE; 3.
PROSITE; PS00290; IG_MHC; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Direct protein sequencing;
Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
Phosphoprotein; Reference proteome; Repeat; SH3-binding; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1..31
CHAIN 32..513
/note="Tyrosine-protein phosphatase non-receptor type
substrate 1"
/id="PRO_0000014942"
TOPO_DOM 32..373
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 374..394
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 395..511
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 32..137
/note="Ig-like V-type"
DOMAIN 149..248
/note="Ig-like C1-type 1"
DOMAIN 255..343
/note="Ig-like C1-type 2"
MOTIF 440..443
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 450..455
/note="SH3-binding"
/evidence="ECO:0000255"
MOTIF 464..467
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 481..484
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 505..508
/note="SH2-binding"
/evidence="ECO:0000255"
MOD_RES 440
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000255"
MOD_RES 464
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000255"
MOD_RES 481
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000250|UniProtKB:P97710"
MOD_RES 505
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000250|UniProtKB:P97710"
CARBOHYD 54
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 92
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 168
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 180
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 205
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 209
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 246
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16944957"
CARBOHYD 271
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 293
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 302
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 312
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 320
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 345
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 367
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 55..121
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 171..229
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 274..332
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
VAR_SEQ 147..364
/note="Missing (in isoform 3 and isoform 4)"
/evidence="ECO:0000303|PubMed:10585853,
ECO:0000303|PubMed:9348339, ECO:0000303|PubMed:9712903"
/id="VSP_007031"
VAR_SEQ 425..428
/note="Missing (in isoform 2 and isoform 4)"
/evidence="ECO:0000303|PubMed:10585853,
ECO:0000303|PubMed:9070220, ECO:0000303|PubMed:9073522,
ECO:0000303|PubMed:9348339, ECO:0000303|PubMed:9712903"
/id="VSP_007032"
CONFLICT 6
/note="Missing (in Ref. 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 10
/note="R -> L (in Ref. 3; AAB92591)"
/evidence="ECO:0000305"
CONFLICT 29
/note="A -> V (in Ref. 1; BAA13520/BAA13521, 5; BAA89289/
BAA89290, 6; AAK56107 and 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 32
/note="K -> T (in Ref. 2; BAA20376)"
/evidence="ECO:0000305"
CONFLICT 34
/note="L -> V (in Ref. 2; BAA20376)"
/evidence="ECO:0000305"
CONFLICT 52
/note="V -> I (in Ref. 2; BAA20376)"
/evidence="ECO:0000305"
CONFLICT 57
/note="L -> V (in Ref. 2; BAA20376)"
/evidence="ECO:0000305"
CONFLICT 67
/note="R -> K (in Ref. 1; BAA13520/BAA13521, 3; AAB92591,
5; BAA89289/BAA89290, 6; AAK56107 and 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 74..77
/note="PSRL -> KAGC (in Ref. 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 74
/note="P -> Q (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290 and 6; AAK56107)"
/evidence="ECO:0000305"
CONFLICT 83
/note="A -> T (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290, 6; AAK56107 and 7;
CAA71375)"
/evidence="ECO:0000305"
CONFLICT 86
/note="Y -> H (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290, 6; AAK56107 and 7;
CAA71375)"
/evidence="ECO:0000305"
CONFLICT 87
/note="V -> F (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290, 6; AAK56107 and 7;
CAA71375)"
/evidence="ECO:0000305"
CONFLICT 90
/note="I -> V (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290, 6; AAK56107 and 7;
CAA71375)"
/evidence="ECO:0000305"
CONFLICT 91
/note="R -> T (in Ref. 1; BAA13520/BAA13521, 5; BAA89289/
BAA89290, 6; AAK56107 and 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 96
/note="T -> A (in Ref. 1; BAA13520/BAA13521, 5; BAA89289/
BAA89290, 6; AAK56107 and 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 114
/note="A -> E (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290, 6; AAK56107 and 7;
CAA71375)"
/evidence="ECO:0000305"
CONFLICT 118
/note="I -> T (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290, 6; AAK56107 and 7;
CAA71375)"
/evidence="ECO:0000305"
CONFLICT 126
/note="K -> R (in Ref. 2; BAA20376 and 3; AAB92591)"
/evidence="ECO:0000305"
CONFLICT 128
/note="S -> P (in Ref. 1; BAA13520/BAA13521, 5; BAA89289/
BAA89290, 6; AAK56107 and 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 154..156
/note="VSG -> YPV (in Ref. 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 164
/note="D -> Y (in Ref. 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 194
/note="P -> H (in Ref. 1; BAA13520/BAA13521, 3; AAB92591,
5; BAA89289/BAA89290 and 6; AAK56107)"
/evidence="ECO:0000305"
CONFLICT 224
/note="N -> H (in Ref. 1; BAA13520/BAA13521, 3; AAB92591,
5; BAA89289/BAA89290, 6; AAK56107 and 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 263
/note="S -> P (in Ref. 2; BAA20376)"
/evidence="ECO:0000305"
CONFLICT 276
/note="A -> D (in Ref. 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 351
/note="F -> L (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290, 6; AAK56107 and 7;
CAA71375)"
/evidence="ECO:0000305"
CONFLICT 365
/note="D -> G (in Ref. 1; BAA13520/BAA13521, 2; BAA20376,
3; AAB92591, 5; BAA89289/BAA89290, 6; AAK56107 and 7;
CAA71375)"
/evidence="ECO:0000305"
CONFLICT 448..458
/note="EKKPAPRAPEP -> RRKPAPGSLEFL (in Ref. 7; CAA71375)"
/evidence="ECO:0000305"
CONFLICT 490
/note="S -> N (in Ref. 2; BAA20376 and 3; AAB92591)"
/evidence="ECO:0000305"
STRAND 40..45
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 51..53
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 56..58
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 66..73
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 77..82
/evidence="ECO:0007744|PDB:2YZ1"
TURN 87..89
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 92..95
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 98..100
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 106..108
/evidence="ECO:0007744|PDB:2YZ1"
HELIX 113..115
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 117..125
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 128..131
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 133..137
/evidence="ECO:0007744|PDB:2YZ1"
STRAND 141..145
/evidence="ECO:0007744|PDB:2YZ1"
SEQUENCE 513 AA; 56414 MW; F3C483B0DC99BD9A CRC64;
MEPAGPAPGR LGPLLLCLLL SASCFCTGAT GKELKVTQPE KSVSVAAGDS TVLNCTLTSL
LPVGPIRWYR GVGPSRLLIY SFAGEYVPRI RNVSDTTKRN NMDFSIRISN VTPADAGIYY
CVKFQKGSSE PDTEIQSGGG TEVYVLAKPS PPEVSGPADR GIPDQKVNFT CKSHGFSPRN
ITLKWFKDGQ ELHPLETTVN PSGKNVSYNI SSTVRVVLNS MDVNSKVICE VAHITLDRSP
LRGIANLSNF IRVSPTVKVT QQSPTSMNQV NLTCRAERFY PEDLQLIWLE NGNVSRNDTP
KNLTKNTDGT YNYTSLFLVN SSAHREDVVF TCQVKHDQQP AITRNHTVLG FAHSSDQGSM
QTFPDNNATH NWNVFIGVGV ACALLVVLLM AALYLLRIKQ KKAKGSTSST RLHEPEKNAR
EITQVQSLIQ DTNDINDITY ADLNLPKEKK PAPRAPEPNN HTEYASIETG KVPRPEDTLT
YADLDMVHLS RAQPAPKPEP SFSEYASVQV QRK


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Related Genes :
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[Sirpa Bit Mfr Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (Macrophage membrane protein MFP150) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[SIRPA MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CD300A CMRF35H IGSF12 HSPC083] CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
[CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f)
[PTPN11 PTP2C SHPTP2] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[Ptpn6 Hcp Hcph Ptp1C] Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)
[Ptprc Ly-5] Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (Lymphocyte antigen 5) (Ly-5) (T200) (CD antigen CD45)
[Cd300lf Clm1 Lmir3] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Leukocyte mono-Ig-like receptor 3) (Myeloid-associated immunoglobulin-like receptor 5) (MAIR-5) (MAIR-V) (CD antigen CD300f)
[IL13RA1 IL13R IL13RA] Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)
[Cd79a Iga Mb-1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[Cd244 2b4 Nmrk] Natural killer cell receptor 2B4 (NK cell type I receptor protein 2B4) (NKR2B4) (Non-MHC restricted killing associated) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[Ptpn11] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
[CD79A IGA MB1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[Ptprs] Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
[PTPRC CD45] Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
[DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[KLRD1 CD94] Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
[CD80 CD28LG CD28LG1 LAB7] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
[PTPRF LAR] Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)
[CD244 2B4] Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)

Bibliography :
No related Items