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Uncharacterized protein

 A0A287BRJ4_PIG          Unreviewed;       295 AA.
A0A287BRJ4;
22-NOV-2017, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 1.
05-JUN-2019, entry version 15.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000059262};
Name=CCND1 {ECO:0000313|Ensembl:ENSSSCP00000059262};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000059262, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000059262, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000059262,
ECO:0000313|Proteomes:UP000008227};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000059262}
IDENTIFICATION.
Ensembl;
Submitted (OCT-2017) to UniProtKB.
-!- SIMILARITY: Belongs to the cyclin family.
{ECO:0000256|RuleBase:RU000383, ECO:0000256|SAAS:SAAS00861960}.
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EMBL; AEMK02000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_013849460.1; XM_013994006.1.
STRING; 9823.ENSSSCP00000013684; -.
Ensembl; ENSSSCT00000046016; ENSSSCP00000059262; ENSSSCG00000037900.
GeneTree; ENSGT00940000157816; -.
OMA; YRTTHFL; -.
Reactome; R-SSC-187577; SCF(Skp2)-mediated degradation of p27/p21.
Reactome; R-SSC-3214858; RMTs methylate histone arginines.
Reactome; R-SSC-69231; Cyclin D associated events in G1.
Reactome; R-SSC-75815; Ubiquitin-dependent degradation of Cyclin D.
Reactome; R-SSC-8849470; PTK6 Regulates Cell Cycle.
Reactome; R-SSC-8878166; Transcriptional regulation by RUNX2.
Reactome; R-SSC-8934593; Regulation of RUNX1 Expression and Activity.
Reactome; R-SSC-8951936; RUNX3 regulates p14-ARF.
Proteomes; UP000008227; Chromosome 2.
GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0017053; C:transcriptional repressor complex; IEA:Ensembl.
GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:Ensembl.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0070064; F:proline-rich region binding; IEA:Ensembl.
GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0007595; P:lactation; IEA:Ensembl.
GO; GO:0097421; P:liver regeneration; IEA:Ensembl.
GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
GO; GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Ensembl.
GO; GO:0031571; P:mitotic G1 DNA damage checkpoint; IEA:Ensembl.
GO; GO:0071157; P:negative regulation of cell cycle arrest; IEA:Ensembl.
GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
GO; GO:0000320; P:re-entry into mitotic cell cycle; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0044321; P:response to leptin; IEA:Ensembl.
GO; GO:0070141; P:response to UV-A; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
CDD; cd00043; CYCLIN; 1.
InterPro; IPR039361; Cyclin.
InterPro; IPR013763; Cyclin-like.
InterPro; IPR036915; Cyclin-like_sf.
InterPro; IPR004367; Cyclin_C-dom.
InterPro; IPR015451; Cyclin_D.
InterPro; IPR006671; Cyclin_N.
PANTHER; PTHR10177; PTHR10177; 1.
PANTHER; PTHR10177:SF67; PTHR10177:SF67; 1.
Pfam; PF02984; Cyclin_C; 1.
Pfam; PF00134; Cyclin_N; 1.
PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
SMART; SM00385; CYCLIN; 1.
SMART; SM01332; Cyclin_C; 1.
SUPFAM; SSF47954; SSF47954; 2.
PROSITE; PS00292; CYCLINS; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000008227};
Cyclin {ECO:0000256|RuleBase:RU000383, ECO:0000256|SAAS:SAAS00862020};
Reference proteome {ECO:0000313|Proteomes:UP000008227}.
DOMAIN 57 88 Cyclin N-terminal.
{ECO:0000259|PROSITE:PS00292}.
REGION 264 295 Disordered. {ECO:0000256|MobiDB-
lite:A0A287BRJ4}.
SEQUENCE 295 AA; 33545 MW; DDE6705EF3F07C23 CRC64;
MAHQLLCCEM ETIRRAYPDA NLLNDRVLRA MLKAEETCSP SVSYFKCVQK EILPSMRKIV
ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT
AEKLCIYTDN SIRPDELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPV AEENKQIIRK
HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLHLGSS NSFLSYHRLT RFLSRVIRCD
PDCLRACQEQ IEALLESSLR QAQQQTLDPK AAEEEEEEEE VDLACTPTDV RDVNI


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Pathways :
WP1165: G Protein Signaling Pathways
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WP799: NLR proteins
WP1672: Mismatch repair
WP73: G Protein Signaling Pathways
WP953: Cytoplasmic Ribosomal Proteins
WP1493: Carbon assimilation C4 pathway
WP1909: Signal regulatory protein (SIRP) family interactions
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP1566: Citrate cycle (TCA cycle)
WP210: Cytoplasmic Ribosomal Proteins
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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[C1orf94] Uncharacterized protein C1orf94
[1070] Uncharacterized protein 1070
[SPBC902.06] Uncharacterized protein C902.06
[SPAC17H9.02] Uncharacterized helicase C17H9.02 (EC 3.6.4.-)
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[31301270] HprK is a serine kinase that regulates virulence in the Gram-negative phytopathogen Xanthomonas campestris.
[31299006] Evolution, purification, and characterization of RC0497: a peptidoglycan amidase from the prototypical spotted fever species Rickettsia conorii.
[31298437] Discovery of Receptor-Ligand Interfaces in the Immunoglobulin Superfamily.
[31297061] Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress.
[31296772] Protein interaction networks revealed by proteome coevolution.
[31296352] Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry.
[31293987] Serial Systemic Infection Highlighted by Proteomics.
[31293010] Novel SCA19/22-associated KCND3 mutations disrupt human K 4.3 protein biosynthesis and channel gating.
[31289188] Structural Analysis of a Nitrogenase Iron Protein from Methanosarcina acetivorans: Implications for CO Capture by a Surface-Exposed [FeS] Cluster.