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Uncharacterized protein

 A0A452E7E5_CAPHI        Unreviewed;       433 AA.
A0A452E7E5;
08-MAY-2019, integrated into UniProtKB/TrEMBL.
08-MAY-2019, sequence version 1.
12-AUG-2020, entry version 8.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCHIP00000007888};
Name=SPRED1 {ECO:0000313|Ensembl:ENSCHIP00000007888};
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Caprinae; Capra.
NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000007888};
[1] {ECO:0000313|Ensembl:ENSCHIP00000007888}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
Phillippy A.M., Van Tassell C.P., Smith T.P.;
"Polished mammalian reference genomes with single-molecule sequencing and
chromosome conformation capture applied to the Capra hircus genome.";
Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCHIP00000007888}
IDENTIFICATION.
Ensembl;
Submitted (MAR-2019) to UniProtKB.
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EMBL; LWLT01000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSCHIT00000015639; ENSCHIP00000007888; ENSCHIG00000011243.
GeneTree; ENSGT00940000159180; -.
OMA; CGDGTKL; -.
Proteomes; UP000291000; Chromosome 10.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
GO; GO:0005173; F:stem cell factor receptor binding; IEA:Ensembl.
GO; GO:0000188; P:inactivation of MAPK activity; IEA:Ensembl.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:Ensembl.
GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:0090311; P:regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
CDD; cd10574; EVH1_SPRED-like; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR023337; KBD.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR041937; SPRE_EVH1.
InterPro; IPR007875; Sprouty.
InterPro; IPR000697; WH1/EVH1_dom.
Pfam; PF05210; Sprouty; 1.
Pfam; PF00568; WH1; 1.
SMART; SM00461; WH1; 1.
PROSITE; PS51488; KBD; 1.
PROSITE; PS51227; SPR; 1.
PROSITE; PS50229; WH1; 1.
4: Predicted;
Membrane {ECO:0000256|ARBA:ARBA00023136};
Reference proteome {ECO:0000313|Proteomes:UP000291000}.
DOMAIN 1..113
/note="WH1"
/evidence="ECO:0000259|PROSITE:PS50229"
DOMAIN 222..274
/note="KBD"
/evidence="ECO:0000259|PROSITE:PS51488"
REGION 256..277
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 256..273
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 433 AA; 49296 MW; 504151A453387028 CRC64;
INSYARVRAV VMTRDDSSGG WLPLGGSGLS CVTVFKVPHQ EENGCADFFI RGERLRDKMV
VLECMLKKDL IYNKVTPTFH HWKIDDKKFG LTFQSPADAR AFDRGIRRAI EDISQGCPSF
KNEAEGTEDN LQVTEEDTSS SLVKDHLFHQ DTVVTSEPYR SSRPSPFEGL NARSVYLRSQ
ANQIMFSHPG LDIQDRSLEY GQRQMPKESG GLKSQNKVPL KSIRHVSFQD EDEIVRINPR
DILIRRYADY RHPDMWKNDL ERDDTDSSVQ FSKPDSKKSD YLYSCGDETK LSSLKDSVVF
KTQPSSLKFK KSKRRKEDGE RSRCVYCQER FNHEENGRGK CQDAPDPIKR CIYQVSCMLC
AESMLYHCMS DSEGDFSDPC SCDTSDDKFC LRWLALVALS FIVPCMCCYV PLRMCHRCGE
ACGCCGGKHK AAG


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[C10orf55] Uncharacterized protein C10orf55
[C1orf94] Uncharacterized protein C1orf94
[C1orf109] Uncharacterized protein C1orf109
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[32948902] The Arabidopsis KH-domain protein FLOWERING LOCUS Y delays flowering by upregulating FLOWERING LOCUS C family members.
[32946437] Transcriptomic profiling of the digestive tract of the rat flea, Xenopsylla cheopis, following blood feeding and infection with Yersinia pestis.
[32943632] Exploiting biofilm phenotypes for functional characterization of hypothetical genes in Enterococcus faecalis.
[32938958] Activity-based protein profiling of rice (Oryza sativa L.) bran serine hydrolases.
[32937585] DNB-based on-chip motif finding: A high-throughput method to profile different types of protein-DNA interactions.
[32937101] Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase.
[32933572] Identification and characterization a novel polar tube protein (NbPTP6) from the microsporidian Nosema bombycis.
[32929263] Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses.
[32929011] PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition.
[32927165] Preserved antibacterial activity of ribosomal protein S15 during evolution.