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Uncharacterized protein

 A0A4X2LW94_VOMUR        Unreviewed;       303 AA.
A0A4X2LW94;
18-SEP-2019, integrated into UniProtKB/TrEMBL.
18-SEP-2019, sequence version 1.
17-JUN-2020, entry version 6.
SubName: Full=CRK like proto-oncogene, adaptor protein {ECO:0000313|Ensembl:ENSVURP00010028358};
Name=CRKL {ECO:0000313|Ensembl:ENSVURP00010028358};
Vombatus ursinus (Common wombat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Metatheria; Diprotodontia; Vombatidae; Vombatus.
NCBI_TaxID=29139 {ECO:0000313|Ensembl:ENSVURP00010028358};
[1] {ECO:0000313|Ensembl:ENSVURP00010028358}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Yazar S.;
Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSVURP00010028358}
IDENTIFICATION.
Ensembl;
Submitted (JUL-2019) to UniProtKB.
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Ensembl; ENSVURT00010032316; ENSVURP00010028358; ENSVURG00010021705.
Proteomes; UP000314987; Unassembled WGS sequence.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0098890; C:extrinsic component of postsynaptic membrane; IEA:Ensembl.
GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IEA:Ensembl.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0001783; P:B cell apoptotic process; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
GO; GO:0098761; P:cellular response to interleukin-7; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0098749; P:cerebellar neuron development; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:1904888; P:cranial skeletal system development; IEA:Ensembl.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0035685; P:helper T cell diapedesis; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0060465; P:pharynx development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:1903977; P:positive regulation of glial cell migration; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0038026; P:reelin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
GO; GO:0050773; P:regulation of dendrite development; IEA:Ensembl.
GO; GO:1904393; P:regulation of skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
GO; GO:2000404; P:regulation of T cell migration; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
GO; GO:0007338; P:single fertilization; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
CDD; cd11758; SH3_CRK_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035457; CRK_SH3_N.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
Pfam; PF07653; SH3_2; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000314987};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}.
DOMAIN 14..102
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
DOMAIN 123..183
/note="SH3"
/evidence="ECO:0000259|PROSITE:PS50002"
DOMAIN 235..296
/note="SH3"
/evidence="ECO:0000259|PROSITE:PS50002"
REGION 183..233
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 303 AA; 33515 MW; FC4EDD9B7979BF18 CRC64;
MAAARFDSAD RSAWYVGPLS RQEAQGRLQG QRHGVFLVRD SSTCPGDYVL SVSENSRVSH
YIINSLPNRR FKIGDQEFEH LPALLEFYKI HYLDTTTLLE PAPRYPSPPM GSASAPNLPP
AEESVEYVRT LYEFSGNDPE DLAFKKGEVL AIVEKPEEQW WSARNKDGQV GMIPVPYVEK
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTANPLPAVS SPPGAVMSPP PSTQNGPVFA
KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIIDPQNPD
ENE


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EIAAB07546 L7rn6,Lethal gene on chromosome 7 Rinchik 6 protein,Mouse,Mus musculus,Uncharacterized protein C11orf73 homolog
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18-003-44281 Putative uncharacterized protein - N_A Polyclonal 0.1 mg Protein A
18-003-44025 Uncharacterized protein KIAA1849 - N_A Polyclonal 0.1 mg Protein A
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EH1144 Uncharacterized protein C13orf33 Elisa Kit 96T
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Pathways :
WP2371: Parkinsons Disease Pathway
WP540: Cytoplasmic Ribosomal Proteins
WP1049: G Protein Signaling Pathways
WP1713: Two-component system
WP163: Cytoplasmic Ribosomal Proteins
WP1659: Glycine, serine and threonine metabolism
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1644: DNA replication
WP2272: Pathogenic Escherichia coli infection
WP288: NLR proteins

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Bibliography :
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[32645368] Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.
[32640994] Proteomic analysis of Rickettsia akari proposes a 44‚ÄČkDa-OMP as a potential biomarker for Rickettsialpox diagnosis.
[32635213] Evolutionary and Predictive Functional Insights into the Aquaporin Gene Family in the Allotetraploid Plant .
[32633954] Proteomics reveals the mechanism underlying the inhibition of Phytophthora sojae by propyl gallate.
[32621220] Prediction of Intrinsic Disorder with Quality Assessment Using QUARTER.
[32619487] FGF Pyramus Has a Transmembrane Domain and Cell-Autonomous Function in Polarity.