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Uncharacterized protein

 M3YTF0_MUSPF            Unreviewed;       725 AA.
M3YTF0;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
16-OCT-2019, entry version 45.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMPUP00000014610};
Name=PIK3R1 {ECO:0000313|Ensembl:ENSMPUP00000014610};
Mustela putorius furo (European domestic ferret) (Mustela furo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
Mustelinae; Mustela.
NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000014610, ECO:0000313|Proteomes:UP000000715};
[1] {ECO:0000313|Ensembl:ENSMPUP00000014610}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000014610};
Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
Walker B.J., Young S., Birren B., Lindblad-Toh K.;
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMPUP00000014610}
IDENTIFICATION.
Ensembl;
Submitted (MAR-2013) to UniProtKB.
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EMBL; AEYP01061723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01061724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_004764567.1; XM_004764510.2.
STRING; 9668.ENSMPUP00000014610; -.
Ensembl; ENSMPUT00000014843; ENSMPUP00000014610; ENSMPUG00000014719.
GeneID; 101683710; -.
CTD; 5295; -.
eggNOG; KOG4637; Eukaryota.
eggNOG; ENOG410XP6R; LUCA.
GeneTree; ENSGT00940000155553; -.
InParanoid; M3YTF0; -.
OMA; TEWSERQ; -.
Proteomes; UP000000715; Unassembled WGS sequence.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:1990578; C:perinuclear endoplasmic reticulum membrane; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0043125; F:ErbB-3 class receptor binding; IEA:Ensembl.
GO; GO:0043559; F:insulin binding; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IEA:Ensembl.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
GO; GO:0005168; F:neurotrophin TRKA receptor binding; IEA:Ensembl.
GO; GO:0036312; F:phosphatidylinositol 3-kinase regulatory subunit binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
GO; GO:0001678; P:cellular glucose homeostasis; IEA:Ensembl.
GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0060396; P:growth hormone receptor signaling pathway; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0033120; P:positive regulation of RNA splicing; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
GO; GO:0046626; P:regulation of insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0051492; P:regulation of stress fiber assembly; IEA:Ensembl.
GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
CDD; cd09930; SH2_cSH2_p85_like; 1.
CDD; cd09942; SH2_nSH2_p85_like; 1.
CDD; cd11910; SH3_PI3K_p85alpha; 1.
Gene3D; 1.10.555.10; -; 1.
Gene3D; 3.30.505.10; -; 2.
InterPro; IPR032498; PI3K_P85_iSH2.
InterPro; IPR035591; PI3K_p85alpha_SH3.
InterPro; IPR035020; PI3kinase_P85_cSH2.
InterPro; IPR035022; PI3kinase_P85_nSH2.
InterPro; IPR008936; Rho_GTPase_activation_prot.
InterPro; IPR000198; RhoGAP_dom.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
Pfam; PF16454; PI3K_P85_iSH2; 1.
Pfam; PF00620; RhoGAP; 1.
Pfam; PF00017; SH2; 2.
PRINTS; PR00401; SH2DOMAIN.
SMART; SM00324; RhoGAP; 1.
SMART; SM00252; SH2; 2.
SMART; SM00326; SH3; 1.
SUPFAM; SSF48350; SSF48350; 1.
SUPFAM; SSF50044; SSF50044; 1.
SUPFAM; SSF55550; SSF55550; 2.
PROSITE; PS50238; RHOGAP; 1.
PROSITE; PS50001; SH2; 2.
PROSITE; PS50002; SH3; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000715};
Reference proteome {ECO:0000313|Proteomes:UP000000715};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}.
DOMAIN 3 79 SH3. {ECO:0000259|PROSITE:PS50002}.
DOMAIN 114 302 Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
DOMAIN 334 429 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 625 719 SH2. {ECO:0000259|PROSITE:PS50001}.
REGION 80 111 Disordered. {ECO:0000256|SAM:MobiDB-
lite}.
COILED 450 470 {ECO:0000256|SAM:Coils}.
COILED 515 563 {ECO:0000256|SAM:Coils}.
COMPBIAS 84 98 Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SEQUENCE 725 AA; 83772 MW; CFBCA66465196C89 CRC64;
MSAEGYQYRA LYDYKKERDE DIDLHLGDVL TVNKGSLVAL GFSDGQEARP EEIGWLNGYN
ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG SSKAEADSEQ QQALALPDLA
EQFAPPDIAP PLLVKLLEAI EKKGLECSTL YRTQSSSNPA ELRQLLDCDA ASMDLEMIDV
QVLGDAFKRY LMDLPNPVIP VAVYNEMIYL AQEVQSSEDY IQLLKKLIRA PNIPHQYWLT
LQYLLKHFFK LCQTSSKNLL SARVLSELFS PLLFRFPAAS SENTEHLIKV IEILISTEWN
ERQPAPALPP KPPKPTSVAN NGMNNNMSLQ DAEWYWGDIS REEVNEKLRD TADGTFLVRD
ASTKMHGDYT LTLRKGGNNK LIKIFHRDGK YGFSDPLTFN SVVELINHYR NESLAQYNPK
LDVKLLYPVS KYQQDQVVKE DNIEAVGKKL HEYNTQFQEK SREYDRLYED YTRTSQEIQM
KRTAIEAFNE TIKIFEEQCQ SQERYSKEYI EKFKREGNEK EIQRIMHNYE KLKSRISEIV
DSRRRLEEDL KKQAAEYREI DKRMNSIKPD LIQLRKTRDQ YLMWLTQKGV RQKKLNEWLG
NENTEDQYSL VEDDEDLPHH DEKTWNVGSS NRNKAENLLR GKRDGTFLVR ESSKQGCYAC
SVVVDGEVKH CVINKTATGY GFAEPYNLYS SLKELVLHYQ HTSLVQHNDS LNVTLAYPVY
AQQRR


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Pathways :
WP1713: Two-component system
WP163: Cytoplasmic Ribosomal Proteins
WP1659: Glycine, serine and threonine metabolism
WP2371: Parkinsons Disease Pathway
WP540: Cytoplasmic Ribosomal Proteins
WP1049: G Protein Signaling Pathways
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1665: Limonene and pinene degradation
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP288: NLR proteins
WP1692: Protein export
WP1239: Cytoplasmic Ribosomal Proteins

Related Genes :

Bibliography :
[31710151] Arabidopsis PIC30 encodes a Major Facilitator Superfamily (MFS) transporter responsible for the uptake of picolinate herbicides.
[31708941] Temporal Quantitative Changes in the Resistant and Susceptible Wheat Leaf Apoplastic Proteome During Infection by Wheat Leaf Rust ().
[31707562] Resonance assignments of bacteriophage T4 Y04L protein.
[31706275] Mumps: MMR vaccination and genetic diversity of mumps virus, 2007-2011 in Catalonia, Spain.
[31706031] Arabidopsis ECAP is a New Adaptor Protein that Connects JAZ Repressors with TPR2 Co-repressor to Suppress Jasmonate-Responsive Anthocyanin Accumulation.
[31690808] Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.
[31690629] Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI.
[31684194] Genome-Wide Analysis of Known and Potential Tetraspanins in .
[31680162] Gene knockdown in malaria parasites via non-canonical RNAi.
[31677787] Predicting novel disease mutations in the cardiac sodium channel.