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Uncharacterized protein

 W5Q9N5_SHEEP            Unreviewed;      1035 AA.
W5Q9N5;
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
08-MAY-2019, entry version 41.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000019427};
Name=TLR8 {ECO:0000313|Ensembl:ENSOARP00000019427};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019427, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000019427, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019427};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
Wang J., Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000019427}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00596625}.
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EMBL; AMGL01113776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9940.ENSOARP00000019427; -.
Ensembl; ENSOART00000019697; ENSOARP00000019427; ENSOARG00000018099.
GeneTree; ENSGT00940000160879; -.
OMA; RWMDENL; -.
Proteomes; UP000002356; Chromosome X.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027175; TLR8.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR47410:SF1; PTHR47410:SF1; 1.
Pfam; PF00560; LRR_1; 1.
Pfam; PF13855; LRR_8; 6.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 16.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 19.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002356};
Immunity {ECO:0000256|SAAS:SAAS00179614};
Innate immunity {ECO:0000256|SAAS:SAAS00179614};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00179597};
Reference proteome {ECO:0000313|Proteomes:UP000002356};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 1035 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004870028.
TRANSMEM 821 842 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 872 1019 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 1035 AA; 118664 MW; 1C962B14BB6E307F CRC64;
ENMTLRFLLL TSLFLLISDS CEFFTEASYP RSYPCDVKNK NGSFIAECNS RRLQEVPQTV
DKAVTEVDLS DNFITRITNE SFQGLQNLTK INLNHNAKSQ SGNPAVKKAM TITYGAFLNL
KHLRELLLED NQLQEIPAGL PESLKELSLI QNNIITLTKK NTSGLGNLER LYLGWNCYFA
CNKKFSIENG AFQNLTKLKV LSLSFNPLHS VPPSLPSSLT ELYLSNTHIG NVSEEDFKEL
SNLRVLDLSG NCPRCFNAPF PCVPCQGGAS IQIHPLAFQT LTQLRYLNLS STSLRKVPAS
WFDNMHNLKV LDLEFNYLMD EIASGEFLTK LPSLEILDLS YNYELKKYPQ YINISKNFSK
LISLQMLHLR GYVFQELRRK DFKPLQHLSN LTTINLGVNF IKQIDFSIFH WFPNLKIVYL
SENRISPLVS DTEQHDANGT FFQSHILKRR SADIQFDPHS NFYHNTHPLI KTECSRLGNA
LDLSLNSIFF IGVNQFKDFG NISCLNLSSN GNGQVLNGTE FSRLSGIKYL DLTNNRLDFD
DDAAFSELPL LEVLDLSYNA HYFRIAGVTH RLGFIEHLTN LRVLNLSNND IFTLTETQLK
SASLGELVFS GNRLDLLWNA QDVRYWQIFQ NLTNLTRLDL ARNNLQHISS QAFLNLPRTL
TDLYINDNML NFFNWSLLEY FPHLRLLDLS GNQLFFLTNS LSTFASSLET LLLSRNRISH
LPSDFLSGAS SLIHLDLSSN QLKMLNRSTF ETKTATKLTI LELGSNPFDC TCDFGDFREW
MDRNLNVRVP RLTDVICASP GDQEGKSIVS LDLTTCVSDT IAAIFCFLTF SVTISVMLAA
LAHHWFYWDA WFIYHVCLAK VKGYRSLSTS QTFYDAYVSY DTKDASVTDW VINELRFHLE
ESEDKNVLLC LEERDWDPGL AIIDNLMQSI NQSKKTIFVL TKKYAKNWNF KTAFYLALQR
LMEENMDVIV FILLEPVLQH SQYLRLRQRI CKSSILQWPD NPKAEGLFWQ SLKNVVLTAN
DSRYNNLYVN SIKQY


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