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Uncharacterized protein

 W5QFK9_SHEEP            Unreviewed;       445 AA.
W5QFK9;
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
17-JUN-2020, entry version 43.
SubName: Full=Sprouty related EVH1 domain containing 1 {ECO:0000313|Ensembl:ENSOARP00000021507};
Name=SPRED1 {ECO:0000313|Ensembl:ENSOARP00000021507};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000021507, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000021507, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000021507,
ECO:0000313|Proteomes:UP000002356};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000021507}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
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EMBL; AMGL01102589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01102590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_012036561.1; XM_012181171.1.
STRING; 9940.ENSOARP00000021507; -.
Ensembl; ENSOART00000021809; ENSOARP00000021507; ENSOARG00000020030.
GeneTree; ENSGT00940000159180; -.
HOGENOM; CLU_038867_1_1_1; -.
OMA; CGDGTKL; -.
OrthoDB; 759156at2759; -.
Proteomes; UP000002356; Chromosome 7.
ExpressionAtlas; W5QFK9; baseline.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
GO; GO:0005173; F:stem cell factor receptor binding; IEA:Ensembl.
GO; GO:0000188; P:inactivation of MAPK activity; IEA:Ensembl.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:Ensembl.
GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:0090311; P:regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
CDD; cd10574; EVH1_SPRED-like; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR023337; KBD.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR041937; SPRE_EVH1.
InterPro; IPR007875; Sprouty.
InterPro; IPR000697; WH1/EVH1_dom.
Pfam; PF05210; Sprouty; 1.
Pfam; PF00568; WH1; 1.
SMART; SM00461; WH1; 1.
PROSITE; PS51488; KBD; 1.
PROSITE; PS51227; SPR; 1.
PROSITE; PS50229; WH1; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Reference proteome {ECO:0000313|Proteomes:UP000002356}.
DOMAIN 8..125
/note="WH1"
/evidence="ECO:0000259|PROSITE:PS50229"
DOMAIN 234..286
/note="KBD"
/evidence="ECO:0000259|PROSITE:PS51488"
REGION 268..289
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 129..149
/evidence="ECO:0000256|SAM:Coils"
COMPBIAS 268..285
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 445 AA; 50667 MW; C455E35299699598 CRC64;
MEKLISNLCI YFSNSYARVR AVVMTRDDSS GGWLPLGGSG LSCVTVFKVP HQEENGCADF
FIRGERLRDK MVVLECMLKK DLIYNKVTPT FHHWKIDDKK FGLTFQSPAD ARAFDRGIRR
AIEDISQGCP SFKNEAEGTE DNLQAAEEDT SSSLVKDHLF HQDTVVTSEP YRSSRPSPFE
GLNARSVYLR SQANQIMFSH PGLDIQDRSL EYGQRQMPKE SGGLKSQNKV PLKSIRHVSF
QDEDEIVRIN PRDILIRRYA DYRHPDMWKN DLERDDTDSS VQFSKPDSKK SDYLYSCGDE
TKLSSLKDSV VFKTQPSSLK FKKSKRRKED GERSRCVYCQ ERFNHEENGR GKCQDAPDPI
KRCIYQVSCM LCAESMLYHC MSDSEGDFSD PCSCDTSDDK FCLRWLALVA LSFIVPCMCC
YVPLRMCHRC GEACGCCGGK HKAAG


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WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
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WP1616: ABC transporters
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[NKAPD1 C11orf57] Uncharacterized protein NKAPD1 (NKAP domain containing protein 1)
[C14orf119 My028] Uncharacterized protein C14orf119
[C1orf94] Uncharacterized protein C1orf94
[C10orf55] Uncharacterized protein C10orf55
[C1orf109] Uncharacterized protein C1orf109
[C19orf57] Uncharacterized protein C19orf57 (Pre-T/NK cell-associated protein 3B3)
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[C4orf45] Uncharacterized protein C4orf45
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[C11orf87] Uncharacterized protein C11orf87
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[C20orf85] Uncharacterized protein C20orf85
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Bibliography :
[32754614] Comparative Genomics and Evolutionary Analysis of RNA-Binding Proteins of the CsrA Family in the Genus .
[32749952] sp. nov., isolated from a freshwater lake.
[32744794] Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder.
[32744249] Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis.
[32743959] Resistance to serine in Bacillus subtilis: Identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism.
[32743570] Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoV.
[32743000] From the Uncharacterized Protein Family 0016 to the GDT1 family: Molecular insights into a newly-characterized family of cation secondary transporters.
[32737119] Selective Disruption of Synaptic BMP Signaling by a Smad Mutation Adjacent to the Highly Conserved H2 Helix.
[32736701] Megalin-mediated albumin endocytosis in cultured murine mesangial cells.
[32736135] Analysis of the proteins secreted by Trichoderma harzianum P49P11 under carbon-limited conditions.