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Uncharacterized protein

 W5QFK9_SHEEP            Unreviewed;       445 AA.
W5QFK9;
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
11-DEC-2019, entry version 41.
SubName: Full=Sprouty related EVH1 domain containing 1 {ECO:0000313|Ensembl:ENSOARP00000021507};
Name=SPRED1 {ECO:0000313|Ensembl:ENSOARP00000021507};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000021507, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000021507, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000021507,
ECO:0000313|Proteomes:UP000002356};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000021507}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
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EMBL; AMGL01102589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01102590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_012036561.1; XM_012181171.1.
STRING; 9940.ENSOARP00000021507; -.
Ensembl; ENSOART00000021809; ENSOARP00000021507; ENSOARG00000020030.
GeneTree; ENSGT00940000159180; -.
OMA; YLYPCGD; -.
OrthoDB; 759156at2759; -.
Proteomes; UP000002356; Chromosome 7.
ExpressionAtlas; W5QFK9; baseline.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
GO; GO:0005173; F:stem cell factor receptor binding; IEA:Ensembl.
GO; GO:0000188; P:inactivation of MAPK activity; IEA:Ensembl.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0010923; P:negative regulation of phosphatase activity; IEA:Ensembl.
GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:0090311; P:regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
CDD; cd10574; EVH1_SPRED-like; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR023337; KBD.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR041937; SPRE_EVH1.
InterPro; IPR007875; Sprouty.
InterPro; IPR000697; WH1/EVH1_dom.
Pfam; PF05210; Sprouty; 1.
Pfam; PF00568; WH1; 1.
SMART; SM00461; WH1; 1.
PROSITE; PS51488; KBD; 1.
PROSITE; PS51227; SPR; 1.
PROSITE; PS50229; WH1; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Reference proteome {ECO:0000313|Proteomes:UP000002356}.
DOMAIN 8..125
/note="WH1"
/evidence="ECO:0000259|PROSITE:PS50229"
DOMAIN 234..286
/note="KBD"
/evidence="ECO:0000259|PROSITE:PS51488"
REGION 268..289
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 129..149
/evidence="ECO:0000256|SAM:Coils"
COMPBIAS 268..285
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 445 AA; 50667 MW; C455E35299699598 CRC64;
MEKLISNLCI YFSNSYARVR AVVMTRDDSS GGWLPLGGSG LSCVTVFKVP HQEENGCADF
FIRGERLRDK MVVLECMLKK DLIYNKVTPT FHHWKIDDKK FGLTFQSPAD ARAFDRGIRR
AIEDISQGCP SFKNEAEGTE DNLQAAEEDT SSSLVKDHLF HQDTVVTSEP YRSSRPSPFE
GLNARSVYLR SQANQIMFSH PGLDIQDRSL EYGQRQMPKE SGGLKSQNKV PLKSIRHVSF
QDEDEIVRIN PRDILIRRYA DYRHPDMWKN DLERDDTDSS VQFSKPDSKK SDYLYSCGDE
TKLSSLKDSV VFKTQPSSLK FKKSKRRKED GERSRCVYCQ ERFNHEENGR GKCQDAPDPI
KRCIYQVSCM LCAESMLYHC MSDSEGDFSD PCSCDTSDDK FCLRWLALVA LSFIVPCMCC
YVPLRMCHRC GEACGCCGGK HKAAG


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WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
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[C1orf94] Uncharacterized protein C1orf94
[1070] Uncharacterized protein 1070
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Bibliography :
[31974111] Cep44 functions in centrosome cohesion by stabilizing rootletin.
[31969871] Acetylation of BcHpt Lysine 161 Regulates Sensitivity to Fungicides, Multistress Adaptation and Virulence.
[31968229] Is the E. coli Homolog of the Formate/Nitrite Transporter Family an Anion Channel? A Computational Study.
[31964818] Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.
[31964336] Reverse engineering directed gene regulatory networks from transcriptomics and proteomics data of biomining bacterial communities with approximate Bayesian computation and steady-state signalling simulations.
[31959619] LRIT3 is required for Nyctalopin expression and normal ON and OFF pathway signaling in the retina.
[31959106] Differential basal expression of immune genes confers Crassostrea gigas resistance to Pacific oyster mortality syndrome.
[31951095] Upregulation of BCAM and its sense lncRNA BAN are associated with gastric cancer metastasis and poor prognosis.
[31950164] The mirid bug Apolygus lucorum deploys a glutathione peroxidase as a candidate effector to enhance plant susceptibility.
[31948069] Arabidopsis Class II Formins AtFH13 and AtFH14 Can Form Heterodimers but Exhibit Distinct Patterns of Cellular Localization.