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Uncharacterized protein (Fragment)

 D2H0T0_AILME            Unreviewed;      1041 AA.
D2H0T0;
09-FEB-2010, integrated into UniProtKB/TrEMBL.
09-FEB-2010, sequence version 1.
08-MAY-2019, entry version 79.
SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFB23641.1, ECO:0000313|Ensembl:ENSAMEP00000020826};
Flags: Fragment;
Name=TLR8 {ECO:0000313|Ensembl:ENSAMEP00000020826};
ORFNames=PANDA_003055 {ECO:0000313|EMBL:EFB23641.1};
Ailuropoda melanoleuca (Giant panda).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
Ailuropoda.
NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB23641.1};
[1] {ECO:0000313|EMBL:EFB23641.1, ECO:0000313|Ensembl:ENSAMEP00000020826}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20010809; DOI=10.1038/nature08696;
Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
Wang J., Wang J.;
"The sequence and de novo assembly of the giant panda genome.";
Nature 463:311-317(2010).
[2] {ECO:0000313|Ensembl:ENSAMEP00000020826}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00596625}.
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EMBL; ACTA01152959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GL192414; EFB23641.1; -; Genomic_DNA.
STRING; 9646.ENSAMEP00000020826; -.
Ensembl; ENSAMET00000021595; ENSAMEP00000020826; ENSAMEG00000019770.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00940000160879; -.
HOGENOM; HOG000230468; -.
OMA; RWMDENL; -.
TreeFam; TF351113; -.
Proteomes; UP000008912; Unassembled WGS sequence.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027175; TLR8.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR47410:SF1; PTHR47410:SF1; 1.
Pfam; PF13855; LRR_8; 5.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 16.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 18.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000008912};
Immunity {ECO:0000256|SAAS:SAAS00179614};
Innate immunity {ECO:0000256|SAAS:SAAS00179614};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878};
Receptor {ECO:0000256|SAAS:SAAS00179597};
Reference proteome {ECO:0000313|Proteomes:UP000008912};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 1041 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015088197.
DOMAIN 878 1025 TIR. {ECO:0000259|PROSITE:PS50104}.
NON_TER 1 1 {ECO:0000313|EMBL:EFB23641.1}.
NON_TER 1041 1041 {ECO:0000313|EMBL:EFB23641.1}.
SEQUENCE 1041 AA; 119262 MW; C75777DAE6685AB1 CRC64;
ENMTLPSLLL TCLFLLISDS YEFFTKANHS RSYPCDERRQ NGSIIAECNS RRLQEVPQTV
GKYVTALDLS DNYITHITNE SFQGLQNLTK INLNHNANPQ HLNENADINK HGMNITDGAF
LSLQNLNQLL LEDNQLYQIP AGLPGSLKEL SLIQNNIIWV TKKNTSGFAN LERLYLSWNC
YFGNNCDNKT FDIEDGTFEG LTNLKVLSLS FNKLVHVPPK LPDSLRELYL SNAKIKIISQ
EDFKGLRNLR VLDLSGNCPR CFNAPFPCTP CEGGSSIQIH PLAFQTLTEL RYLNLSSTSL
RKIPATWFEN MHKLKVLHLE FNYLVDEIAS GEFLTKLPSL EILDLSFNYV KAKYPKYITI
SQNFSNLQLL QALHLRGYVF QELRAEDFHP LMGLSNLKTI NLGVNFIKQI NFTLFQNFTN
LTVIYLSENR ISPLVNDIRQ NDVSSSSSPS HVLKPRSADV EFDPHSNFYH NTNPLIKPQC
AVYGKALDLS LNSIFFIGRE QFEAFHDIAC LNLSSNGNGQ VLHGTEFSAV PHVKYLDLTN
NRLDFDDDNA LSELPELEVL DLSYNAHYFR IAGVTHRLGF IQNLTQLKVL NLSHNGIYTL
TEQDLRSMSL EELVFSGNRL DILWNAEGDK YWKIFTSLRN LTRLDLSSNN LRRIPNEAFL
NLPQSLTQLY IKNNVLNFFN WTLLQQFPHL QTLDLSGNRL SSLTNSLSKF TPSLRTLLLH
RNRIAHLPAN FLSEASSLIH LDLSSNLLKM INKSTLQTKT NTSLAILELG RNPFDCTCDI
GDFRRWMDEN LDVTIPRLTD VICSSPGDQK GKSIVSLELT TCISDTIAAV LCFFTSFVTI
TVMLAALGHH WFYWDVWFIY HVCLAKVKGY RSLSTSQTFY DAYVSYDTKD ASVTDWVINE
LRFHLEESEG KNVLLCLEER DWDPGLAIID NLMQSINQSK KTIFVLTKKY AQNWNFKTAF
YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EGLFWQSLKN
VVLTENNSRY NNLYVDSIKQ Y


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[Adgrg1 Cyt28 Gpr56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Serpentine receptor cyt28) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1-CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[Adgrg1 Gpr56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[Myoc Tigr] Myocilin (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]
[C3] Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[c3] Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] (Fragment)
[Ptprn Ptp35] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[PTPRN ICA3 ICA512] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[Ptprn] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (105 kDa islet cell antigen) (BEM-3) (Brain-enriched membrane-associated protein tyrosine phosphatase) (ICA105) (ICA512) (PTP IA-2) (PTPLP) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[Myoc Tigr] Myocilin (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]
[PTPRN] Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell autoantigen 512) (ICA512) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
[ADGRG6 DREG GPR126 VIGR] Adhesion G-protein coupled receptor G6 (Developmentally regulated G-protein-coupled receptor) (G-protein coupled receptor 126) (Vascular inducible G protein-coupled receptor) [Cleaved into: ADGRG6 N-terminal fragment (ADGRG6-NTF); ADGRG6 C-terminal fragment (ADGRG6-CTF)]

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