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Urea transporter

 A0A1Q5WGI8_SERMA        Unreviewed;       325 AA.
A0A1Q5WGI8;
12-APR-2017, integrated into UniProtKB/TrEMBL.
12-APR-2017, sequence version 1.
25-OCT-2017, entry version 4.
SubName: Full=Urea transporter {ECO:0000313|EMBL:OKP54501.1};
ORFNames=A8A12_23350 {ECO:0000313|EMBL:OKP54501.1};
Serratia marcescens.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Yersiniaceae; Serratia.
NCBI_TaxID=615 {ECO:0000313|EMBL:OKP54501.1, ECO:0000313|Proteomes:UP000185968};
[1] {ECO:0000313|EMBL:OKP54501.1, ECO:0000313|Proteomes:UP000185968}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SM03 {ECO:0000313|EMBL:OKP54501.1,
ECO:0000313|Proteomes:UP000185968};
Srinivasan V.B., Rajamohan G.;
"Genome sequence of Serratia marcescens.";
Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:OKP54501.1}.
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EMBL; LZOB01000002; OKP54501.1; -; Genomic_DNA.
RefSeq; WP_074053630.1; NZ_LZOB01000002.1.
Proteomes; UP000185968; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0015204; F:urea transmembrane transporter activity; IEA:InterPro.
Gene3D; 1.10.3430.10; -; 1.
InterPro; IPR029020; Ammonium/urea_transptr.
InterPro; IPR004937; Urea_transporter.
InterPro; IPR017807; Urea_transporter_bac.
PANTHER; PTHR10464; PTHR10464; 1.
Pfam; PF03253; UT; 1.
PIRSF; PIRSF016502; Urea_transporter; 1.
TIGRFAMs; TIGR03441; urea_trans_yut; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000185968};
Membrane {ECO:0000256|SAM:Phobius};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 32 51 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 58 77 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 107 127 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 134 157 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 193 213 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 220 238 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 244 265 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 272 290 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 302 323 Helical. {ECO:0000256|SAM:Phobius}.
SITE 303 303 Important for channel permeability.
{ECO:0000256|PIRSR:PIRSR016502-1}.
SEQUENCE 325 AA; 34176 MW; 8AFF442E462C269B CRC64;
MTTKWDWAGL CVRCRVAAAT DAVLRGCSQV MFQNNPLTGL LFFIAIFVGA WEEGLPQVAF
GCLLGTATAT LSAAWLVDDR AALRSGLYGY NGCLVGAALP TFLLPSAWLW VGVIFCGAIS
VIVTVGLNRL LRTWQIAALT APFVLTTWTV LLASYPFSHL RHVRLPPAAI PADGAVFNAH
PEMMEMLNGA LHGVSQVFLC SSVSGGLLLL LGLAVSSPRA MLLAFSGALL AVATALAIGA
DPQAVFAGLY AFSAVLTAVA LGSVFNPPGR RVLIYTLLGV IFTVLVQGAF NTLLAPLGMP
SLTMPFVIAS WLFLSANPAV IAARR


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1455: Serotonin Transporter Activity
WP1493: Carbon assimilation C4 pathway
WP153: Urea cycle and metabolism of amino groups
WP1616: ABC transporters
WP1621: Arginine and proline metabolism
WP1623: Atrazine degradation
WP1680: Oxidative phosphorylation
WP1689: Porphyrin and chlorophyll metabolism
WP1693: Purine metabolism
WP1713: Two-component system
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP2345: vitamin B7 (biotin) biosynthesis pathway
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP426: Urea cycle and metabolism of amino groups
WP497: Urea cycle and metabolism of amino groups

Related Genes :
[Slc14a1] Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter B) (UT-B) (Urea transporter, erythrocyte)
[SLC14A1 UT-B] Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter B) (UT-B) (Urea transporter, erythrocyte)
[SLC14A1 HUT11 JK RACH1 UT1 UTE] Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)
[SLC14A2 HUT2 UT2] Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)
[Slc14a2 Ut2] Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)
[Slc14a1 UT11 UT3] Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter B) (UT-B) (Urea transporter, erythrocyte)
[DUR3 YHL016C] Urea active transporter
[Slc14a2 Ut2] Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)
[DVU_1160] Urea transporter DVU1160 (dvUT)
[DUR3 At5g45380 MFC19.5] Urea-proton symporter DUR3 (AtDUR3) (High-affinity urea active transporter DUR3)
[ureA hpuA HP_0073] Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha)
[DUR1,2 YBR208C YBR1448] Urea amidolyase [Includes: Urea carboxylase (EC 6.3.4.6); Allophanate hydrolase (EC 3.5.1.54)]
[ureC] Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha)
[DUR3 Os10g0580400 LOC_Os10g42960 OsJ_32609 OSJNBa0056G17.4] Urea-proton symporter DUR3 (OsDUR3) (High-affinity urea active transporter DUR3)
[ureB hpuB HP_0072] Urease subunit beta (EC 3.5.1.5) (Urea amidohydrolase subunit beta)
[ureI HP_0071] Acid-activated urea channel (Urease accessory protein UreI)
[ureC PMI3685] Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha)
[ppnP CXF74_16150] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[ppnP CXF93_13280] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[glmU CXF91_03190] Bifunctional protein GlmU [Includes: Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase)]
[fadB CXF93_16700] Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]
[cobA cysG CXF74_17830] Siroheme synthase [Includes: Sirohydrochlorin ferrochelatase (EC 4.99.1.4); Uroporphyrinogen-III C-methyltransferase (Urogen III methylase) (EC 2.1.1.107) (Uroporphyrinogen III methylase) (UROM) (SUMT); Precorrin-2 dehydrogenase (EC 1.3.1.76)]
[nnrE nnrD CXF93_13440] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[glmU CXF93_16910] Bifunctional protein GlmU [Includes: Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase)]
[glmU CXF74_16205] Bifunctional protein GlmU [Includes: Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase)]
[nnrD nnrE CXF74_01135] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[ribBA CXF91_12860] Riboflavin biosynthesis protein RibBA [Includes: GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II); 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12)]
[ureC CXF93_07840] Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha)
[ureC Rv1850 MTCY359.23c] Urease subunit alpha (EC 3.5.1.5) (Urea amidohydrolase subunit alpha)
[DUR1,2 PYD13,15 URC3,5] Urea amidolyase (Pyrimidine-degrading protein 13,15) (Uracil catabolism protein 3,5) [Includes: Urea carboxylase (EC 6.3.4.6); Allophanate hydrolase (EC 3.5.1.54)]

Bibliography :
[31067085] Emerging new role of NFAT5 in the inducible nitric oxide synthase in response to hypoxia in MEF cells.
[31033226] Sickle cell disease up-regulates vasopressin, aquaporin 2, urea transporter A1, Na-K-Cl cotransporter 2, and epithelial Na channels in the mouse kidney medulla despite compromising urinary concentration ability.
[30959323] Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors.
[30560275] [Renal physiology of urea transporters].
[30503629] Ontogeny of urea and ammonia transporters in mahi-mahi (Coryphaena hippurus) early life stages.
[30426495] The urea transporter DUR3 contributes to rice production under nitrogen-deficient and field conditions.
[30367514] Urea-modulated UT-B urea transporter internalization is clathrin- and caveolae-dependent in infantile hemangioma-derived vascular endothelial cells.
[30290033] Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
[30183395] Effect of dietary nitrogen level and source on mRNA expression of urea transporters in the rumen epithelium of fattening bulls.
[30101448] Investigation of facilitative urea transporters in the human gastrointestinal tract.