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Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]

 UROK_PIG                Reviewed;         442 AA.
P04185;
20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
16-JAN-2019, entry version 142.
RecName: Full=Urokinase-type plasminogen activator;
Short=U-plasminogen activator;
Short=uPA;
EC=3.4.21.73;
Contains:
RecName: Full=Urokinase-type plasminogen activator long chain A;
Contains:
RecName: Full=Urokinase-type plasminogen activator short chain A;
Contains:
RecName: Full=Urokinase-type plasminogen activator chain B;
Flags: Precursor;
Name=PLAU;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Kidney;
PubMed=6096832; DOI=10.1093/nar/12.24.9525;
Nagamine Y., Pearson D., Altus M.S., Reich E.;
"cDNA and gene nucleotide sequence of porcine plasminogen activator.";
Nucleic Acids Res. 12:9525-9541(1984).
[2]
SEQUENCE REVISION TO 241.
Nagamine Y.;
Submitted (DEC-1986) to the PIR data bank.
-!- FUNCTION: Specifically cleaves the zymogen plasminogen to form the
active enzyme plasmin.
-!- CATALYTIC ACTIVITY:
Reaction=Specific cleavage of Arg-|-Val bond in plasminogen to
form plasmin.; EC=3.4.21.73;
-!- ACTIVITY REGULATION: Inhibited by SERPINA5. {ECO:0000250}.
-!- SUBUNIT: Found in high and low molecular mass forms. Each consists
of two chains, A and B. The high molecular mass form contains a
long chain A which is cleaved to yield a short chain A. Forms
heterodimer with SERPINA5. Binds LRP1B; binding is followed by
internalization and degradation. Interacts with MRC2. Interacts
with PLAUR (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase S1 family.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
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EMBL; X01648; CAA25806.1; -; Genomic_DNA.
EMBL; X02724; CAA26511.1; -; mRNA.
PIR; A00932; UKPG.
RefSeq; NP_999110.1; NM_213945.1.
UniGene; Ssc.11194; -.
ProteinModelPortal; P04185; -.
SMR; P04185; -.
STRING; 9823.ENSSSCP00000010995; -.
ChEMBL; CHEMBL1075030; -.
MEROPS; S01.231; -.
PaxDb; P04185; -.
PRIDE; P04185; -.
GeneID; 396985; -.
KEGG; ssc:396985; -.
CTD; 5328; -.
eggNOG; ENOG410IGFI; Eukaryota.
eggNOG; COG5640; LUCA.
HOGENOM; HOG000237314; -.
HOVERGEN; HBG008633; -.
InParanoid; P04185; -.
KO; K01348; -.
OrthoDB; 1314811at2759; -.
PRO; PR:P04185; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0042730; P:fibrinolysis; IBA:GO_Central.
GO; GO:0031639; P:plasminogen activation; IBA:GO_Central.
GO; GO:0006508; P:proteolysis; IBA:GO_Central.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IBA:GO_Central.
CDD; cd00108; KR; 1.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.20.10; -; 1.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000001; Kringle.
InterPro; IPR013806; Kringle-like.
InterPro; IPR018056; Kringle_CS.
InterPro; IPR038178; Kringle_sf.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
InterPro; IPR034814; Urokinase.
PANTHER; PTHR24264:SF38; PTHR24264:SF38; 1.
Pfam; PF00051; Kringle; 1.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00130; KR; 1.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF57440; SSF57440; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS50026; EGF_3; 1.
PROSITE; PS00021; KRINGLE_1; 1.
PROSITE; PS50070; KRINGLE_2; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein;
Hydrolase; Kringle; Plasminogen activation; Protease;
Reference proteome; Secreted; Serine protease; Signal; Zymogen.
SIGNAL 1 20 {ECO:0000250}.
CHAIN 21 442 Urokinase-type plasminogen activator.
/FTId=PRO_0000028330.
CHAIN 21 188 Urokinase-type plasminogen activator long
chain A. {ECO:0000250}.
/FTId=PRO_0000028331.
CHAIN 167 188 Urokinase-type plasminogen activator
short chain A. {ECO:0000250}.
/FTId=PRO_0000285900.
CHAIN 190 442 Urokinase-type plasminogen activator
chain B. {ECO:0000250}.
/FTId=PRO_0000028332.
DOMAIN 29 65 EGF-like. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 72 153 Kringle. {ECO:0000255|PROSITE-
ProRule:PRU00121}.
DOMAIN 190 435 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
REGION 36 59 Binds urokinase plasminogen activator
surface receptor. {ECO:0000250}.
REGION 154 189 Connecting peptide.
ACT_SITE 235 235 Charge relay system.
ACT_SITE 286 286 Charge relay system.
ACT_SITE 387 387 Charge relay system.
CARBOHYD 152 152 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 33 41 {ECO:0000250}.
DISULFID 35 53 {ECO:0000250}.
DISULFID 55 64 {ECO:0000250}.
DISULFID 72 153 {ECO:0000250}.
DISULFID 93 135 {ECO:0000250}.
DISULFID 124 148 {ECO:0000250}.
DISULFID 179 310 Interchain (between A and B chains).
{ECO:0000255|PROSITE-ProRule:PRU00076,
ECO:0000255|PROSITE-ProRule:PRU00121,
ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 220 236 {ECO:0000250}.
DISULFID 228 299 {ECO:0000250}.
DISULFID 324 393 {ECO:0000250}.
DISULFID 356 372 {ECO:0000250}.
DISULFID 383 411 {ECO:0000250}.
CONFLICT 241 241 Q -> H (in Ref. 1; CAA25806).
{ECO:0000305}.
CONFLICT 242 242 Q -> H (in Ref. 1; CAA26511).
{ECO:0000305}.
CONFLICT 288 288 A -> GS (in Ref. 1; CAA25806).
{ECO:0000305}.
SEQUENCE 442 AA; 49117 MW; EE32FCEF501321EE CRC64;
MRVLRACLSL CVLVVSDSKG SHELHQESGA SNCGCLNGGK CVSYKYFSNI QRCSCPKKFQ
GEHCEIDTSQ TCFEGNGHSY RGKANTNTGG RPCLPWNSAT VLLNTYHAHR PDALQLGLGK
HNYCRNPDNQ RRPWCYVQVG LKQLVQECMV PNCSGGESHR PAYDGKNPFS TPEKVEFQCG
QKALRPRFKI VGGKSTTIEN QPWFAAIYRR HRGGSVTYVC GGSLISPCWV VSATHCFINY
QQKEDYIVYL GRQTLHSSTH GEMKFEVEKL ILHEDYSADS LAHHNDIALL KIRTDKGQCA
QPSRSIQTIC LPPVNGDAHF GASCEIVGFG KEDPSDYLYP EQLKMTVVKL VSHRECQQPH
YYGSEVTTKM LCAADPQWKT DSCQGDSGGP LVCSTQGRLT LTGIVSWGRE CAMKDKPGVY
TRVSRFLTWI HTHVGGENGL AH


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Pathways :
WP2148: Brain derived neurotrophic factor
WP2151: tPa pathway
WP2152: BDNF
WP1017: Type II interferon signaling (IFNG)
WP1136: Type II interferon signaling (IFNG)
WP1253: Type II interferon signaling (IFNG)
WP1289: Type II interferon signaling (IFNG)
WP1350: Type II interferon signaling (IFNG)
WP1584: Type II diabetes mellitus
WP1614: 1- and 2-Methylnaphthalene degradation
WP1626: Benzoate degradation via CoA ligation
WP1633: Bisphenol A degradation
WP1647: Fatty acid biosynthesis
WP1654: gamma-Hexachlorocyclohexane degradation
WP1665: Limonene and pinene degradation
WP1673: Naphthalene and anthracene degradation
WP1708: Terpenoid backbone biosynthesis
WP1996: Linoleate Biosynthesis
WP2113: Type III interferon signaling
WP2272: Pathogenic Escherichia coli infection
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2434: very-long-chain-fatty-acid-biosynthesis
WP585: Interferon type I
WP619: Type II interferon signaling (IFNG)
WP786: Type II interferon signaling (IFNG)

Related Genes :
[PLAT] Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
[Plat] Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
[Plat] Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
[PLAT] Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
[SERPINE1 PAI1 PLANH1] Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
[PLG] Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]
[SERPINA5 PCI PLANH3 PROCI] Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)
[PLAT] Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
[Plg] Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]
[PLAT] Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
[HLTF HIP116A RNF80 SMARCA3 SNF2L3 ZBU1] Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)
[] Venom plasminogen activator LV-PA (EC 3.4.21.-) (LMUT0402S) (Plasminogen activating proteinase) (Snake venom serine protease) (SVSP)
[HABP2 HGFAL PHBP] Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
[] Venom plasminogen activator TSV-PA (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[Serpinb2 Pai2 Planh2] Plasminogen activator inhibitor 2, macrophage (PAI-2) (Serpin B2)
[botA atx bonT] Botulinum neurotoxin type A (BoNT/A) (Bontoxilysin-A) (BOTOX) (Botulinum neurotoxin type A1) [Cleaved into: Botulinum neurotoxin A light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A heavy chain (HC)]
[botA bna CBO0806 CLC_0862] Botulinum neurotoxin type A (BoNT/A) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A heavy chain (HC)]
[ENO1 ENO1L1 MBPB1 MPB1] Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)
[botA atx bna bonT CLM_0897] Botulinum neurotoxin type A2 (BoNT/A) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A2 light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin A2 heavy chain (HC)]
[botB] Botulinum neurotoxin type B (BoNT/B) (Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin B heavy chain (HC)]
[PSAP GLBA SAP1] Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]
[botD] Botulinum neurotoxin type D (BoNT/D) (Bontoxilysin-D) [Cleaved into: Botulinum neurotoxin D light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin D heavy chain (HC)]
[botE] Botulinum neurotoxin type E (BoNT/E) (Bontoxilysin-E) [Cleaved into: Botulinum neurotoxin E light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin E heavy chain (HC)]
[] Botulinum neurotoxin type C (BoNT/C) (Bontoxilysin-C1) (BoNT/C1) (Botulinum neurotoxin type C1) [Cleaved into: Botulinum neurotoxin C light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin C heavy chain (HC)]
[GM2A] Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short]
[botB CLD_A0068] Botulinum neurotoxin type B (BoNT/B) (Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin B heavy chain (HC)]
[Habp2 Phbp] Hyaluronan-binding protein 2 (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
[F2RL1 GPR11 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
[F bont boNT/F CLI_0851] Botulinum neurotoxin type F (BoNT/F) (Bontoxilysin-F) [Cleaved into: Botulinum neurotoxin F light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin F heavy chain (HC)]
[botG] Botulinum neurotoxin type G (BoNT/G) (Bontoxilysin-G) [Cleaved into: Botulinum neurotoxin G light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin G heavy chain (HC)]

Bibliography :