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VIP peptides [Cleaved into: Intestinal peptide PHI-27-like; Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]

 VIP_MELGA               Reviewed;         200 AA.
P45644;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
05-DEC-2018, entry version 81.
RecName: Full=VIP peptides;
Contains:
RecName: Full=Intestinal peptide PHI-27-like;
Contains:
RecName: Full=Vasoactive intestinal peptide;
Short=VIP;
AltName: Full=Vasoactive intestinal polypeptide;
Flags: Precursor;
Name=VIP;
Meleagris gallopavo (Wild turkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Meleagridinae; Meleagris.
NCBI_TaxID=9103;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Nicholas white; TISSUE=Hypothalamus;
PubMed=7750483; DOI=10.1210/endo.136.6.7750483;
You S., Silsby J.L., Farris J.A., Foster D.N., el Halawani M.E.;
"Tissue-specific alternative splicing of turkey preprovasoactive
intestinal peptide messenger ribonucleic acid, its regulation, and
correlation with prolactin secretion.";
Endocrinology 136:2602-2610(1995).
-!- FUNCTION: VIP causes vasodilation, lowers arterial blood pressure,
stimulates myocardial contractility, increases glycogenolysis and
relaxes the smooth muscle of trachea, stomach and gall bladder.
-!- FUNCTION: PHI also causes vasodilation.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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EMBL; L36641; AAA92866.1; -; mRNA.
UniGene; Mga.4459; -.
SMR; P45644; -.
STRING; 9103.ENSMGAP00000019441; -.
eggNOG; ENOG410IW68; Eukaryota.
eggNOG; ENOG4111JKK; LUCA.
HOVERGEN; HBG018069; -.
InParanoid; P45644; -.
Proteomes; UP000001645; Unplaced.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005615; C:extracellular space; TAS:AgBase.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0005184; F:neuropeptide hormone activity; TAS:AgBase.
GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:AgBase.
GO; GO:0048255; P:mRNA stabilization; IDA:AgBase.
GO; GO:0009648; P:photoperiodism; TAS:AgBase.
GO; GO:0010524; P:positive regulation of calcium ion transport into cytosol; IDA:AgBase.
GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
GO; GO:0090277; P:positive regulation of peptide hormone secretion; TAS:AgBase.
GO; GO:0060050; P:positive regulation of protein glycosylation; IDA:AgBase.
GO; GO:0070459; P:prolactin secretion; IDA:AgBase.
InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
InterPro; IPR015523; VIP.
PANTHER; PTHR11213:SF5; PTHR11213:SF5; 1.
Pfam; PF00123; Hormone_2; 2.
SMART; SM00070; GLUCA; 2.
PROSITE; PS00260; GLUCAGON; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 87
/FTId=PRO_0000011481.
PEPTIDE 89 115 Intestinal peptide PHI-27-like.
/FTId=PRO_0000011482.
PROPEP 119 126
/FTId=PRO_0000011483.
PEPTIDE 129 156 Vasoactive intestinal peptide.
/FTId=PRO_0000011484.
PROPEP 160 200
/FTId=PRO_0000011485.
MOD_RES 156 156 Threonine amide. {ECO:0000250}.
SEQUENCE 200 AA; 22601 MW; B35933495273F06D CRC64;
MEHRGTSPLL LALALLSALC WRARALPPRG AAFPAVPRLG NRLPFDAASE SDRAHGSLKS
ESDILQNTLP ENEKFYFDLS RIIDRNDRHA DGIFTTVYSH LLAKLAVKRY LHSLIRKRVS
SQDSPVKRHS DAVFTDNYSR FRKQMAVKKY LNSVLTGKRS QEELNPAKLA DEAEILEPSF
SENYDDVSVD ELLSHLPLDL


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Pathways :
WP1001: Peptide GPCRs
WP1117: Peptide GPCRs
WP131: Peptide GPCRs
WP1338: Peptide GPCRs
WP234: Peptide GPCRs
WP24: Peptide GPCRs
WP771: Peptide GPCRs
WP883: Peptide GPCRs

Related Genes :
[Vip] VIP peptides [Cleaved into: Intestinal peptide PHI-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]
[Vip] VIP peptides [Cleaved into: Intestinal peptide PHV-42; Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]
[VIP] VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]
[VIP] VIP peptides [Cleaved into: Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] (Fragment)
[VIP] VIP peptides [Cleaved into: Intestinal peptide PHI-27 (Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]
[VIP] VIP peptides [Cleaved into: Intestinal peptide PHI-27-like; Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]
[VIPR1] Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1)
[GUCY2C GUC2C STAR] Heat-stable enterotoxin receptor (STA receptor) (hSTAR) (EC 4.6.1.2) (Guanylyl cyclase C) (GC-C) (Intestinal guanylate cyclase)
[GCG] Glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]
[vip vip1] Vasoactive intestinal polypeptide type I
[TFF3 ITF TFI] Trefoil factor 3 (Intestinal trefoil factor) (hITF) (Polypeptide P1.B) (hP1.B)
[VIP EGK_15243] VIP peptides isoform 1 preproprotein (Vasoactive intestinal peptide)
[vip] Vasoactive intestinal peptide
[] Bradykinin-potentiating and C-type natriuretic peptides (Brain BPP-CNP) (bBPP-CNP) (Evasin-CNP) [Cleaved into: Bradykinin-potentiating peptide 13a+QQWA (BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA (BPP-13a+QWA); Bradykinin-potentiating peptide 13a (BPP-13a); Bradykinin-potentiating peptide 10c+QQWA (BPP-10c+QQWA); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Evasin-10c); Bradykinin-potentiating peptide 12b (BPP-12b) (Evasin-12b); Bradykinin-potentiating peptide AP; Bradykinin-potentiating peptide APL (BPP-APL); Bradykinin-potentiating peptide 11e (BPP-11e) (Evasin-11e); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide Va) (BPPVa) (Evasin-5a) (Proline-rich peptide 5a) (Bj-PRO-5a) (PRO-5a); Poly-His-poly-Gly peptide 1 (pHpG-1); C-type natriuretic peptide (Bj-CNP)]
[VIP2 VIH1 At5g15070 F2G14.190] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase VIP2 (EC 2.7.4.21) (EC 2.7.4.24) (Protein VIP HOMOLOG 1) (VIP1 homolog protein 2) (Arabidopsis homolog protein of yeast VIP1 2) (AtVIP2)
[VIP1 QVE7 VIH2 At3g01310 T22N4.6 T4P13.1] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase VIP1 (EC 2.7.4.21) (EC 2.7.4.24) (Probable protein QUANTITATIVE VITAMIN E-7) (Protein VIP HOMOLOG 2) (VIP1 homolog protein 1) (Arabidopsis homolog protein of yeast VIP1 1) (AtVIP1)
[] Bradykinin-potentiating and C-type natriuretic peptides (BPP-CNP) [Cleaved into: Bradykinin-potentiating peptide 6a (BPP-6a); Bradykinin-potentiating peptide 10a (BPP-10a) (Bradykinin-potentiating peptide IV-1-A) (BPPIV-1-A) (Bradykinin-potentiating peptide V-8); Bradykinin-potentiating peptide 13a+QQWA (BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA (BPP-13a+QWA); Bradykinin-potentiating peptide 13a (BPP-13a) (Bradykinin-potentiating peptide III-1-A) (III-1-A) (Bradykinin-potentiating peptide V-9); Bradykinin-potentiating peptide 10c+QQWA (BPP-10c+QQWA); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Bradykinin-potentiating peptide IV-1-Bbeta) (BPP IV-1-Bbeta) (Bradykinin-potentiating peptide V-7); Bradykinin-potentiating peptide 10c-F (BPP-10c-F); Bradykinin-potentiating peptide 11b (BPP-11b) (Bradykinin-potentiating peptide IIa) (BPP-IIa); Bradykinin-potentiating peptide IIb (BPP-IIb); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide Va) (BPPVa) (Proline-rich peptide 5a) (Bj-PRO-5a) (PRO-5a); Poly-His-poly-Gly peptide 1 (pHpG-1); C-type natriuretic peptide (Bj-CNP)]
[vip] Histidine-isoleucine/vasoactive intestinal polypeptide
[VIP3 SKI8 At4g29830 F27B13.70] WD repeat-containing protein VIP3 (Protein BOUQUET-1) (boq-1) (Protein SKI8 homolog) (Protein VERNALIZATION INDEPENDENCE 3) (Protein ZWERGERL) (zwg)
[VIP CK820_G0037876] VIP isoform 2 (Vasoactive intestinal peptide)
[GCG] Glucagon [Cleaved into: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]
[] Bradykinin-potentiating and C-type natriuretic peptides (Angiotensin-converting enzyme inhibitor) (BPP-CNP homolog) [Cleaved into: Bradykinin-potentiating peptide 13a (BPP-13a) (Bradykinin-potentiating peptide S3,1); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Bradykinin-potentiating peptide S4,3,1); Bradykinin-potentiating peptide 12b (BPP-12b) (Bradykinin-potentiating peptide S4,3,2); Bradykinin-potentiating peptide 11e (BPP-11e); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide S5,2) (Bradykinin-potentiating peptide Va) (BPPVa) (Proline-rich peptide 5a) (PRO-5a); C-type natriuretic peptide (CNP)]
[SI] Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]
[] Bradykinin-potentiating and C-type natriuretic peptides (Angiotensin-converting enzyme inhibitor) (BPP-CNP homolog) [Cleaved into: Blomhotin; Bradykinin-potentiating peptide A (BPP-a) (Potentiator A); Leu3-blomhotin (Potentiator D); Bradykinin-potentiating peptide B (BPP-b) (Potentiator B); Bradykinin-potentiating peptide C (BPP-c) (Potentiator C); Bradykinin-potentiating peptide E (BPP-e) (Potentiator E); Bradykinin-potentiating peptide Ahb1 (BPP-Ahb1); Bradykinin-potentiating peptide Ahb2 (BPP-Ahb2); C-type natriuretic peptide]
[vip] Vasoactive intestinal peptide
[PDZD3 IKEPP NHERF4 PDZK2 DLNB27] Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4)
[] Bradykinin-potentiating and C-type natriuretic peptides (BPP-CNP) [Cleaved into: Bradykinin-potentiating peptide 1 (BPP 1); Bradykinin-potentiating peptide 2 (BPP 2); Bradykinin-potentiating peptide 3 (BPP 3); Bradykinin-potentiating peptide 4 (BPP 4); Bradykinin-potentiating peptide 5 (BPP 5); Bradykinin inhibitor peptide (BIP); C-type natriuretic peptide (CNP)]
[gag] Gag polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27, alternate cleaved 1; Capsid protein p27, alternate cleaved 2; Spacer peptide (SP) (p3); Nucleocapsid protein p12; Protease p15 (EC 3.4.23.-)]
[VIP] Vasoactive intestinal peptide
[VIP] Vasoactive intestinal peptide

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