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Vancomycin/teicoplanin A-type resistance protein VanA (EC 6.1.2.1) (D-alanine--D-lactate ligase) (VanA ligase)

 VANA_ENTFC              Reviewed;         343 AA.
P25051;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
01-MAY-1992, sequence version 1.
05-DEC-2018, entry version 134.
RecName: Full=Vancomycin/teicoplanin A-type resistance protein VanA;
EC=6.1.2.1;
AltName: Full=D-alanine--D-lactate ligase;
AltName: Full=VanA ligase;
Name=vanA;
Enterococcus faecium (Streptococcus faecium).
Plasmid pIP816.
Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
Enterococcus.
NCBI_TaxID=1352;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-9.
STRAIN=BM4147;
PubMed=2266943; DOI=10.1007/BF00262430;
Dutka-Malen S., Molinas C., Arthur M., Courvalin P.;
"The VANA glycopeptide resistance protein is related to D-alanyl-D-
alanine ligase cell wall biosynthesis enzymes.";
Mol. Gen. Genet. 224:364-372(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BM4147;
PubMed=8380148; DOI=10.1128/jb.175.1.117-127.1993;
Arthur M., Molinas C., Depardieu F., Courvalin P.;
"Characterization of Tn1546, a Tn3-related transposon conferring
glycopeptide resistance by synthesis of depsipeptide peptidoglycan
precursors in Enterococcus faecium BM4147.";
J. Bacteriol. 175:117-127(1993).
[3]
FUNCTION, CATALYTIC ACTIVITY, SUBSTRATE SPECIFICITY, AND
BIOPHYSICOCHEMICAL PROPERTIES.
STRAIN=BM4147;
PubMed=1931965; DOI=10.1021/bi00107a007;
Bugg T.D.H., Wright G.D., Dutka-Malen S., Arthur M., Courvalin P.,
Walsh C.T.;
"Molecular basis for vancomycin resistance in Enterococcus faecium
BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by
vancomycin resistance proteins VanH and VanA.";
Biochemistry 30:10408-10415(1991).
[4]
CHARACTERIZATION OF REACTION PRODUCT.
PubMed=1522072; DOI=10.1128/jb.174.18.5982-5984.1992;
Handwerger S., Pucci M.J., Volk K.J., Liu J., Lee M.S.;
"The cytoplasmic peptidoglycan precursor of vancomycin-resistant
Enterococcus faecalis terminates in lactate.";
J. Bacteriol. 174:5982-5984(1992).
[5]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH MAGNESIUM; ADP
AND INHIBITOR.
PubMed=10908650; DOI=10.1073/pnas.150116497;
Roper D.I., Huyton T., Vagin A., Dodson G.;
"The molecular basis of vancomycin resistance in clinically relevant
Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA).";
Proc. Natl. Acad. Sci. U.S.A. 97:8921-8925(2000).
-!- FUNCTION: Required for high-level resistance to glycopeptide
antibiotics. D-Ala--D-Ala ligase of altered specificity which
catalyzes ester bond formation between D-Ala and various D-hydroxy
acids; produces a peptidoglycan which does not terminate in D-
alanine but in D-lactate, thus preventing vancomycin or
teicoplanin binding. {ECO:0000269|PubMed:1931965}.
-!- CATALYTIC ACTIVITY:
Reaction=(R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-
lactate + phosphate; Xref=Rhea:RHEA:37347, ChEBI:CHEBI:16004,
ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57416,
ChEBI:CHEBI:61166, ChEBI:CHEBI:456216; EC=6.1.2.1;
Evidence={ECO:0000269|PubMed:1931965};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Note=Binds 2 magnesium or manganese ions per subunit.
{ECO:0000250};
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=7.1 mM for D-lactate {ECO:0000269|PubMed:1931965};
KM=3.8 mM for D-alanine {ECO:0000269|PubMed:1931965};
KM=0.6 mM for 2-hydroxybutyrate {ECO:0000269|PubMed:1931965};
KM=3.2 mM for 2-hydroxyvalerate {ECO:0000269|PubMed:1931965};
KM=11 mM for 2-hydroxycaproate {ECO:0000269|PubMed:1931965};
-!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
Cytoplasmic side.
-!- INDUCTION: By vancomycin, mediated by VanS/VanR.
-!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
{ECO:0000305}.
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EMBL; X56895; CAA40215.1; -; Genomic_DNA.
EMBL; M97297; AAA65956.1; -; Genomic_DNA.
PIR; S12254; CESOVM.
RefSeq; WP_001079845.1; NZ_UFYT01000005.1.
RefSeq; YP_001019035.1; NC_008821.1.
RefSeq; YP_001974796.1; NC_010980.1.
RefSeq; YP_002128399.1; NC_011140.1.
RefSeq; YP_976077.1; NC_008768.1.
PDB; 1E4E; X-ray; 2.50 A; A/B=1-343.
PDBsum; 1E4E; -.
ProteinModelPortal; P25051; -.
SMR; P25051; -.
BindingDB; P25051; -.
ChEMBL; CHEMBL6037; -.
PRIDE; P25051; -.
GeneID; 4670249; -.
GeneID; 4783144; -.
GeneID; 6385877; -.
GeneID; 6779647; -.
KEGG; ag:CAA40215; -.
KO; K15739; -.
BioCyc; MetaCyc:MONOMER-15466; -.
BRENDA; 6.1.2.1; 2096.
SABIO-RK; P25051; -.
EvolutionaryTrace; P25051; -.
PRO; PR:P25051; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IDA:CACAO.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
Gene3D; 3.30.1490.20; -; 1.
HAMAP; MF_00047; Dala_Dala_lig; 1.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR013815; ATP_grasp_subdomain_1.
InterPro; IPR000291; D-Ala_lig_Van_CS.
InterPro; IPR005905; D_ala_D_ala.
InterPro; IPR011095; Dala_Dala_lig_C.
InterPro; IPR011127; Dala_Dala_lig_N.
InterPro; IPR016185; PreATP-grasp_dom_sf.
Pfam; PF07478; Dala_Dala_lig_C; 1.
Pfam; PF01820; Dala_Dala_lig_N; 1.
PIRSF; PIRSF039102; Ddl/VanB; 1.
SUPFAM; SSF52440; SSF52440; 1.
TIGRFAMs; TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE; PS50975; ATP_GRASP; 1.
PROSITE; PS00843; DALA_DALA_LIGASE_1; 1.
PROSITE; PS00844; DALA_DALA_LIGASE_2; 1.
1: Evidence at protein level;
3D-structure; Antibiotic resistance; ATP-binding; Cell membrane;
Cell shape; Cell wall biogenesis/degradation;
Direct protein sequencing; Ligase; Magnesium; Manganese; Membrane;
Metal-binding; Nucleotide-binding; Peptidoglycan synthesis; Plasmid.
CHAIN 1 343 Vancomycin/teicoplanin A-type resistance
protein VanA.
/FTId=PRO_0000177917.
DOMAIN 137 338 ATP-grasp.
NP_BIND 169 171 ATP.
NP_BIND 177 178 ATP.
NP_BIND 207 214 ATP.
NP_BIND 304 305 ATP.
METAL 305 305 Magnesium 1.
{ECO:0000269|PubMed:10908650}.
METAL 305 305 Magnesium 2.
{ECO:0000269|PubMed:10908650}.
METAL 307 307 Magnesium 2.
{ECO:0000269|PubMed:10908650}.
BINDING 133 133 ATP.
BINDING 241 241 ATP; via amide nitrogen.
BINDING 244 244 Substrate.
STRAND 4 11 {ECO:0000244|PDB:1E4E}.
HELIX 17 30 {ECO:0000244|PDB:1E4E}.
TURN 33 35 {ECO:0000244|PDB:1E4E}.
STRAND 36 43 {ECO:0000244|PDB:1E4E}.
STRAND 49 53 {ECO:0000244|PDB:1E4E}.
STRAND 65 69 {ECO:0000244|PDB:1E4E}.
TURN 73 75 {ECO:0000244|PDB:1E4E}.
STRAND 77 82 {ECO:0000244|PDB:1E4E}.
STRAND 85 90 {ECO:0000244|PDB:1E4E}.
STRAND 92 96 {ECO:0000244|PDB:1E4E}.
TURN 101 103 {ECO:0000244|PDB:1E4E}.
STRAND 104 106 {ECO:0000244|PDB:1E4E}.
HELIX 107 115 {ECO:0000244|PDB:1E4E}.
STRAND 119 121 {ECO:0000244|PDB:1E4E}.
HELIX 124 131 {ECO:0000244|PDB:1E4E}.
HELIX 133 142 {ECO:0000244|PDB:1E4E}.
STRAND 150 153 {ECO:0000244|PDB:1E4E}.
HELIX 161 163 {ECO:0000244|PDB:1E4E}.
STRAND 168 174 {ECO:0000244|PDB:1E4E}.
TURN 177 180 {ECO:0000244|PDB:1E4E}.
STRAND 182 184 {ECO:0000244|PDB:1E4E}.
HELIX 187 189 {ECO:0000244|PDB:1E4E}.
HELIX 190 197 {ECO:0000244|PDB:1E4E}.
TURN 198 200 {ECO:0000244|PDB:1E4E}.
STRAND 202 208 {ECO:0000244|PDB:1E4E}.
STRAND 212 222 {ECO:0000244|PDB:1E4E}.
STRAND 232 239 {ECO:0000244|PDB:1E4E}.
HELIX 243 245 {ECO:0000244|PDB:1E4E}.
STRAND 246 248 {ECO:0000244|PDB:1E4E}.
HELIX 249 251 {ECO:0000244|PDB:1E4E}.
STRAND 254 258 {ECO:0000244|PDB:1E4E}.
HELIX 266 282 {ECO:0000244|PDB:1E4E}.
STRAND 286 295 {ECO:0000244|PDB:1E4E}.
STRAND 301 309 {ECO:0000244|PDB:1E4E}.
HELIX 317 324 {ECO:0000244|PDB:1E4E}.
HELIX 329 341 {ECO:0000244|PDB:1E4E}.
SEQUENCE 343 AA; 37443 MW; AAA48E3B2AD48E03 CRC64;
MNRIKVAILF GGCSEEHDVS VKSAIEIAAN INKEKYEPLY IGITKSGVWK MCEKPCAEWE
NDNCYSAVLS PDKKMHGLLV KKNHEYEINH VDVAFSALHG KSGEDGSIQG LFELSGIPFV
GCDIQSSAIC MDKSLTYIVA KNAGIATPAF WVINKDDRPV AATFTYPVFV KPARSGSSFG
VKKVNSADEL DYAIESARQY DSKILIEQAV SGCEVGCAVL GNSAALVVGE VDQIRLQYGI
FRIHQEVEPE KGSENAVITV PADLSAEERG RIQETAKKIY KALGCRGLAR VDMFLQDNGR
IVLNEVNTLP GFTSYSRYPR MMAAAGIALP ELIDRLIVLA LKG


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1625: Base excision repair
WP1672: Mismatch repair
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair
WP1097: Non-homologous end joining
WP1201: Non-homologous end joining
WP1208: Non-homologous end joining
WP1222: Non-homologous end joining
WP1242: Non-homologous end joining
WP1277: Non-homologous end joining
WP1324: Non-homologous end joining
WP1570: Non-homologous end joining
WP1996: Linoleate Biosynthesis
WP2199: Seed Development
WP2272: Pathogenic Escherichia coli infection
WP296: TCA Cycle - biocyc
WP438: Non-homologous end joining
WP739: Non-homologous end joining
WP753: Non-homologous end joining
WP861: Non-homologous end joining
WP979: Non-homologous end joining
WP1017: Type II interferon signaling (IFNG)
WP104: Alanine and aspartate metabolism
WP1049: G Protein Signaling Pathways
WP106: Alanine and aspartate metabolism

Related Genes :
[vanA] Vancomycin/teicoplanin A-type resistance protein VanA (EC 6.1.2.1) (D-alanine--D-lactate ligase) (VanA ligase)
[vanB vanB2 EF_2294] Vancomycin B-type resistance protein VanB (EC 6.1.2.1) (D-alanine--D-lactate ligase) (VanB ligase)
[ddlB ddl b0092 JW0090] D-alanine--D-alanine ligase B (EC 6.3.2.4) (D-Ala-D-Ala ligase B) (D-alanylalanine synthetase B)
[vanX] D-alanyl-D-alanine dipeptidase (D-Ala-D-Ala dipeptidase) (EC 3.4.13.22) (Vancomycin B-type resistance protein VanX)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CG691_19145 CG705_13560 CG706_14580 CIJ94_05515 COD46_23180 CRD98_26150 D3I61_11545 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTL84_23375 DTM25_06080 EC95NR1_00961 ERS085379_01273 ERS085386_05041 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 SAMEA3753106_00003 SAMEA3753391_00513 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[ddl ddlA Rv2981c MTCY349.06] D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanine:D-alanine ligase) (D-alanylalanine synthetase)
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[pyrG A6592_02570 A8M42_16405 A9R57_06965 AC067_22330 AC789_1c31020 ACN002_2797 ACN77_07080 ACN81_20385 ACU57_24415 ACU90_23015 AJ318_22735 AKG99_03555 AM270_00945 AM446_06950 AM464_05605 AM465_10605 AML07_12460 AML35_05300 APT94_17890 APU18_18535 APZ14_09290 ARC77_10140 AU473_08010 AUQ13_17535 AUS26_15660 AW059_10675 AW106_00665 AWP75_20610 AZZ83_003241 B1K96_20050 B7C53_10055 B9M99_21725 B9N33_09475 B9T59_19685 BB545_13920 BE963_03670 BEN53_16995 BET08_07180 BH694_13410 BHF46_05050 BHS81_16640 BHS87_15735 BIQ87_15835 BIU72_09520 BIZ41_16885 BJJ90_05265 BK248_12970 BK292_23205 BK334_11935 BK373_15870 BK375_10085 BK383_11680 BK400_05820 BMT49_17330 BMT53_21250 BMT91_11105 BN17_26661 BTQ04_11510 BTQ06_23845 BUE81_06975 BVL39_12970 BW690_04975 BWP17_05185 BXT93_24405 BZL31_00820 BZL69_02125 C1I57_04860 C2M16_17770 C2U48_20025 C3K24_08940 C4J69_11655 C4K41_05275 C4M78_00835 C5715_23540 C5N07_06155 C5P01_05005 C5P43_15935 C5P44_09340 C6669_14670 C6986_17750 C6B13_03370 C7235_05745 C7B02_19400 C7B06_11630 C7B07_14530 C7B08_01430 C9E25_03325 CA593_12975 CCZ14_04445 CCZ17_10850 CDL37_13440 CG691_07365 CG692_07005 CG705_05530 CG706_07860 CIJ94_12220 COD30_01795 COD46_07095 CR538_05495 CR539_18815 CRE06_03485 CRM83_26360 CSB64_15850 CT143_09630 CT146_00680 CV83915_03339 CVH05_06295 CWM24_00790 CWS33_03125 CXB56_08765 D0X26_06660 D1900_12730 D2183_19100 D2F89_14380 D3I61_16000 DD762_13665 DIV22_29760 DIV25_29790 DL545_05995 DL800_20505 DNQ41_18960 DNR41_08670 DQE83_04685 DS732_20695 DS966_06010 DTL43_09355 DTL84_00105 DTL90_02675 DTM10_03745 DTM25_22630 DTM27_13675 DTM45_13530 EC1094V2_904 EC3234A_48c00890 EC95NR1_02021 ECONIH1_15890 ECs3640 EL75_0914 EL79_0915 EL80_0918 ERS085365_02427 ERS085366_03042 ERS085374_03279 ERS085386_03410 ERS085416_02898 ERS139211_02072 ERS150873_02003 ERS150876_01467 FORC28_1110 GJ11_18025 HMPREF3040_01161 HW43_18180 JD73_16335 MJ49_17095 MS6198_30910 MS8345_02965 NCTC10082_03473 NCTC10090_04050 NCTC10418_01701 NCTC10764_00296 NCTC10766_00690 NCTC10767_02309 NCTC11022_02860 NCTC11112_00121 NCTC11181_03277 NCTC12950_01251 NCTC13125_04353 NCTC13127_01436 NCTC13462_04807 NCTC13846_01212 NCTC7152_00995 NCTC7927_01209 NCTC8500_01090 NCTC8960_03783 NCTC9007_03892 NCTC9010_01168 NCTC9036_01135 NCTC9037_01243 NCTC9045_01221 NCTC9050_04166 NCTC9058_00847 NCTC9062_02131 NCTC9075_01630 NCTC9077_01409 NCTC9081_05851 NCTC9117_01609 NCTC9119_01271 NCTC9434_01004 NCTC9706_03296 NCTC9775_04845 NCTC9777_02704 NCTC9969_01292 PU06_02080 RG28_07675 RK56_023165 SAMEA3472033_01264 SAMEA3472044_02272 SAMEA3472047_00339 SAMEA3472056_05455 SAMEA3472067_02540 SAMEA3472070_01673 SAMEA3472080_03155 SAMEA3472090_00131 SAMEA3472108_00527 SAMEA3472110_03462 SAMEA3472112_03722 SAMEA3472114_02432 SAMEA3472147_03296 SAMEA3484427_03298 SAMEA3484429_03415 SAMEA3484433_01660 SAMEA3484434_01581 SAMEA3485101_02257 SAMEA3485113_02257 SAMEA3752372_03639 SAMEA3752557_03040 SAMEA3752559_02995 SAMEA3752620_01282 SAMEA3753064_02287 SAMEA3753097_02219 SAMEA3753106_03183 SAMEA3753164_01192 SAMEA3753290_02847 SAMEA3753300_01107 SAMEA3753391_02580 SAMEA3753397_04005 SK85_03024 SY51_15605 UC41_20365 UN91_03645 WM48_14990 WQ89_10170 WR15_06090 YDC107_1339] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[bacD ywfE BSU37710 ipa-83d] Alanine--anticapsin ligase (EC 6.3.2.49) (ATP-dependent dipeptide ligase) (Bacilysin synthetase) (L-Ala-L-amino acid dipeptide ligase) (L-alanine--L-anticapsin ligase) (L-amino acid ligase) (Lal)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[vanA ddl B4W81_17380 DKP91_13550] D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[botD] Botulinum neurotoxin type D (BoNT/D) (Bontoxilysin-D) [Cleaved into: Botulinum neurotoxin D light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin D heavy chain (HC)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.47) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[murC/ddl CT_762] Bifunctional enzyme MurC/Ddl [Includes: UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase); D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase)]
[] Genome polyprotein [Cleaved into: Leader protease (Lpro) (EC 3.4.22.46); Protein VP0 (VP4-VP2); Protein VP4 (P1A) (Virion protein 4); Protein VP2 (P1B) (Virion protein 2); Protein VP3 (P1C) (Virion protein 3); Protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[ddlB ddl A6592_03395 A8C65_16265 A9R57_20470 AC789_1c00920 ACN002_0092 ACU57_16065 AM270_12055 AM446_23170 AMK83_01600 AML07_23605 APT94_27415 APZ14_15185 AUQ13_07885 AUS26_14655 AW059_09405 B1K96_13400 B9M99_18850 BB545_20490 BE963_14430 BET08_06765 BHF46_08275 BHS87_00390 BIQ87_00385 BIU72_13840 BJJ90_21750 BK248_21020 BK292_13285 BK334_15405 BK373_09210 BK400_03995 BMT53_09900 BN17_45141 BUE81_03720 BVL39_02595 BW690_22025 BXT93_15680 BZL31_13400 C2M16_10395 C2U48_10020 C4J69_03845 C5715_27150 C5N07_08165 C5P43_03105 C6669_04670 C6B13_04740 C7235_20640 C7B06_05460 C7B07_04685 C7B08_10095 C9E25_07300 CA593_03280 CG691_02350 CG705_02255 CG706_02205 CIJ94_16040 COD46_06225 CR538_21050 CR539_04520 CRD98_07435 CSB64_19500 CV83915_01485 CXB56_23540 D0X26_09830 D2183_04390 D3I61_01170 DIV22_05860 DIV25_27295 DL545_20825 DNQ41_04210 DS732_05365 DTL43_06335 DTL84_04755 DTM10_02375 DTM45_12235 EC3234A_2c00760 EC95NR1_04273 ECONIH1_00510 EL75_3670 EL79_3780 EL80_3727 ERS085365_01030 ERS085379_00613 ERS085416_01582 ERS139211_00749 ERS150876_00142 FORC28_5107 GJ11_00490 HMPREF3040_02529 HW43_04190 JD73_13510 MJ49_06580 MS6198_01060 NCTC10082_01474 NCTC10865_05166 NCTC11112_03321 NCTC11181_01456 NCTC12950_04502 NCTC13462_02310 NCTC7152_04191 NCTC7927_04585 NCTC8179_01279 NCTC8500_04641 NCTC8622_02554 NCTC8960_01640 NCTC9010_04291 NCTC9036_04103 NCTC9037_04265 NCTC9045_04808 NCTC9050_02102 NCTC9055_01042 NCTC9058_02718 NCTC9062_04138 NCTC9073_03492 NCTC9077_05196 NCTC9111_04341 NCTC9117_05153 NCTC9703_03513 NCTC9706_01499 NCTC9775_02415 NCTC9969_04343 PU06_15025 RK56_013485 RX35_04829 SAMEA3472047_00239 SAMEA3472055_04290 SAMEA3472067_01337 SAMEA3472090_00695 SAMEA3472114_03696 SAMEA3484427_01283 SAMEA3484429_01198 SAMEA3484433_03020 SAMEA3484434_01055 SAMEA3485113_00765 SAMEA3752557_00797 SAMEA3752559_03937 SAMEA3752620_02012 SAMEA3753064_03294 SAMEA3753106_01584 SAMEA3753164_02511 SAMEA3753290_00317 SAMEA3753300_01956 SAMEA3753391_00920 SAMEA3753397_02811 SK85_00090 UN86_27885 UN91_10970 WQ89_09170 WR15_01945 YDC107_3322] D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase)
[POL RR33_62243gpPOL RR33_62244gpPOL] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BHF46_18455 BMT91_24760 C4J69_22715 C7B08_25495 CR538_10415 D2F89_25795 EC3234A_36c00010 NCTC8500_02249 NCTC9010_02117 NCTC9037_02122 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: Leader protease (Lb(pro)) (EC 3.4.22.46); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protein 2A (P2A) (P52); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Protein 3B-1 (P3B-1) (Genome-linked protein VPg1); Protein 3B-2 (P3B-2) (Genome-linked protein VPg2); Protein 3B-3 (P3B-3) (Genome-linked protein VPg3); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C) (Protease P20B); RNA-directed RNA polymerase 3D-POL (P3D-POL) (EC 2.7.7.48) (P56A)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); 3C-like serine proteinase (3CLSP) (EC 3.4.21.-) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Non-structural protein 11 (Nsp11); Non-structural protein 12 (Nsp12)]

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