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WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1)

 WASH1_HUMAN             Reviewed;         465 AA.
A8K0Z3;
08-APR-2008, integrated into UniProtKB/Swiss-Prot.
19-JAN-2010, sequence version 2.
13-FEB-2019, entry version 97.
RecName: Full=WASH complex subunit 1 {ECO:0000312|HGNC:HGNC:24361};
AltName: Full=CXYorf1-like protein on chromosome 9;
AltName: Full=Protein FAM39E;
AltName: Full=WAS protein family homolog 1;
Name=WASHC1 {ECO:0000312|HGNC:HGNC:24361}; Synonyms=FAM39E, WASH1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164053; DOI=10.1038/nature02465;
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[3]
GENE DUPLICATION.
PubMed=10655549; DOI=10.1093/hmg/9.3.395;
Ciccodicola A., D'Esposito M., Esposito T., Gianfrancesco F.,
Migliaccio C., Miano M.G., Matarazzo M.R., Vacca M., Franze A.,
Cuccurese M., Cocchia M., Curci A., Terracciano A., Torino A.,
Cocchia S., Mercadante G., Pannone E., Archidiacono N., Rocchi M.,
Schlessinger D., D'Urso M.;
"Differentially regulated and evolved genes in the fully sequenced
Xq/Yq pseudoautosomal region.";
Hum. Mol. Genet. 9:395-401(2000).
[4]
GENE DUPLICATION.
PubMed=18159949; DOI=10.1371/journal.pgen.0030237;
Linardopoulou E.V., Parghi S.S., Friedman C., Osborn G.E.,
Parkhurst S.M., Trask B.J.;
"Human subtelomeric WASH genes encode a new subclass of the WASP
family.";
PLoS Genet. 3:E237-E237(2007).
[5]
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH WASHC2C,
TUBULIN-BINDING, AND MUTAGENESIS OF TRP-463.
PubMed=19922874; DOI=10.1016/j.devcel.2009.09.009;
Gomez T.S., Billadeau D.D.;
"A FAM21-containing WASH complex regulates retromer-dependent
sorting.";
Dev. Cell 17:699-711(2009).
[6]
FUNCTION, FUNCTION OF THE WASH COMPLEX, AND IDENTIFICATION IN THE WASH
COMPLEX.
PubMed=19922875; DOI=10.1016/j.devcel.2009.09.010;
Derivery E., Sousa C., Gautier J.J., Lombard B., Loew D., Gautreau A.;
"The Arp2/3 activator WASH controls the fission of endosomes through a
large multiprotein complex.";
Dev. Cell 17:712-723(2009).
[7]
FUNCTION, IDENTIFICATION IN THE WASH CORE COMPLEX, AND FUNCTION OF THE
WASH CORE COMPLEX.
PubMed=20498093; DOI=10.1073/pnas.0913293107;
Jia D., Gomez T.S., Metlagel Z., Umetani J., Otwinowski Z.,
Rosen M.K., Billadeau D.D.;
"WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome
protein (WASP) family are controlled by analogous structurally related
complexes.";
Proc. Natl. Acad. Sci. U.S.A. 107:10442-10447(2010).
[8]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=22114305; DOI=10.1242/jcs.080986;
Zech T., Calaminus S.D., Caswell P., Spence H.J., Carnell M.,
Insall R.H., Norman J., Machesky L.M.;
"The Arp2/3 activator WASH regulates alpha5beta1-integrin-mediated
invasive migration.";
J. Cell Sci. 124:3753-3759(2011).
[9]
FUNCTION, UBIQUITINATION AT LYS-220, AND MUTAGENESIS OF LYS-220.
PubMed=23452853; DOI=10.1016/j.cell.2013.01.051;
Hao Y.H., Doyle J.M., Ramanathan S., Gomez T.S., Jia D., Xu M.,
Chen Z.J., Billadeau D.D., Rosen M.K., Potts P.R.;
"Regulation of WASH-dependent actin polymerization and protein
trafficking by ubiquitination.";
Cell 152:1051-1064(2013).
[10]
FUNCTION, INTERACTION WITH EXOC1; EXOC4 AND EXOC8, AND SUBCELLULAR
LOCATION.
PubMed=24344185; DOI=10.1083/jcb.201306162;
Monteiro P., Rosse C., Castro-Castro A., Irondelle M., Lagoutte E.,
Paul-Gilloteaux P., Desnos C., Formstecher E., Darchen F., Perrais D.,
Gautreau A., Hertzog M., Chavrier P.;
"Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at
invadopodia.";
J. Cell Biol. 203:1063-1079(2013).
[11]
INTERACTION WITH TBC1D23.
PubMed=29084197; DOI=10.1038/ncb3627;
Shin J.J.H., Gillingham A.K., Begum F., Chadwick J., Munro S.;
"TBC1D23 is a bridging factor for endosomal vesicle capture by golgins
at the trans-Golgi.";
Nat. Cell Biol. 19:1424-1432(2017).
-!- FUNCTION: Acts as a nucleation-promoting factor (NPF) at the
surface of endosomes, where it recruits and activates the Arp2/3
complex to induce actin polymerization, playing a key role in the
fission of tubules that serve as transport intermediates during
endosome sorting (PubMed:19922874, PubMed:19922875,
PubMed:20498093, PubMed:23452853). Its assembly in the WASH core
complex seems to inhibit its NPF activity and via WASHC2 is
required for its membrane targeting (PubMed:20498093). Involved in
endocytic trafficking of EGF (By similarity). Involved in
transferrin receptor recycling. Regulates the trafficking of
endosomal alpha5beta1 integrin to the plasma membrane and involved
in invasive cell migration (PubMed:22114305). In T-cells involved
in endosome-to-membrane recycling of receptors including T-cell
receptor (TCR), CD28 and ITGAL; proposed to be implicated in T
cell proliferation and effector function. In dendritic cells
involved in endosome-to-membrane recycling of major
histocompatibility complex (MHC) class II probably involving
retromer and subsequently allowing antigen sampling, loading and
presentation during T-cell activation (By similarity). Involved in
Arp2/3 complex-dependent actin assembly driving Salmonella
typhimurium invasion independent of ruffling. Involved in the
exocytosis of MMP14 leading to matrix remodeling during invasive
migration and implicating late endosome-to-plasma membrane tubular
connections and cooperation with the exocyst complex
(PubMed:24344185). Involved in negative regulation of autophagy
independently from its role in endosomal sorting by inhibiting
BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By
similarity). {ECO:0000250|UniProtKB:C4AMC7,
ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874,
ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093,
ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853,
ECO:0000305|PubMed:20498093}.
-!- SUBUNIT: Component of the WASH core complex also described as WASH
regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or
WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5.
The WASH core complex associates via WASHC2 with the F-actin-
capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and
CAPZB) in a transient or substoichiometric manner which was
initially described as WASH complex (PubMed:19922875,
PubMed:20498093). Interacts (via WHD1 region) with WASHC2C; the
interaction is direct (PubMed:19922874). Interacts with VPS35;
mediates the association with the retromer CSC complex. Interacts
with FKBP15. Interacts with alpha-tubulin. Interacts with BECN1;
this interaction can be competed out by AMBRA1 binding. Interacts
with BLOC1S2; may associate with the BLOC-1 complex. Interacts
with tubulin gamma chain (TUBG1 or TUBG2) (By similarity).
Interacts with EXOC1, EXOC4, EXOC8; in MMP14-positive endosomes in
breast tumor cells; indicative for an association with the exocyst
complex (PubMed:24344185). Interacts with TBC1D23
(PubMed:29084197). {ECO:0000250|UniProtKB:Q8VDD8,
ECO:0000250|UniProtKB:Q9Y4E1, ECO:0000269|PubMed:19922874,
ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093,
ECO:0000269|PubMed:24344185, ECO:0000269|PubMed:29084197}.
-!- INTERACTION:
Q14457:BECN1; NbExp=3; IntAct=EBI-6160405, EBI-949378;
Q9NV70:EXOC1; NbExp=2; IntAct=EBI-6160405, EBI-1045313;
Q8IYI6:EXOC8; NbExp=3; IntAct=EBI-6160405, EBI-742102;
-!- SUBCELLULAR LOCATION: Early endosome membrane
{ECO:0000269|PubMed:19922874}. Recycling endosome membrane
{ECO:0000250|UniProtKB:Q8VDD8}. Late endosome
{ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:24344185}.
Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8VDD8}.
Cytoplasm, cytoskeleton, microtubule organizing center,
centrosome, centriole {ECO:0000250|UniProtKB:Q8VDD8}.
Note=Localization to the endosome membrane is mediated via its
interaction with WASHC2 (PubMed:19922874). Localizes to MMP14-
positive late endosomes and transiently to invadipodia
(PubMed:24344185). Localized to Salmonella typhimurium entry sites
(By similarity). {ECO:0000250|UniProtKB:Q8VDD8,
ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:24344185}.
-!- DOMAIN: The VCA (verprolin, cofilin, acidic) domain promotes actin
polymerization by the Arp2/3 complex in vitro.
{ECO:0000250|UniProtKB:C4AMC7}.
-!- PTM: Ubiquitinated at Lys-220 via 'Lys-63'-linked ubiquitin chains
by the TRIM27:MAGEL2 E3 ubiquitin ligase complex, leading to
promote endosomal F-actin assembly. {ECO:0000269|PubMed:23452853}.
-!- MISCELLANEOUS: WASH genes duplicated to multiple chromosomal ends
during primate evolution, with highest copy number reached in
humans, whose WASH repertoires probably vary extensively among
individuals (PubMed:18159949). It is therefore difficult to
determine which gene is functional or not. The telomeric region of
chromosome 9p is paralogous to the pericentromeric regions of
chromosome 9 as well as to 2q. Paralogous regions contain 7
transcriptional units. Duplicated WASH genes are also present in
the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and
15. The chromosome 16 copy seems to be a pseudogene.
{ECO:0000305|PubMed:18159949}.
-!- SIMILARITY: Belongs to the WASH1 family. {ECO:0000305}.
-!- CAUTION: To demonstrate the interaction with WASHC2, a WASHC2C
construct with WASHC2A-specific sequence insertions has been used.
In human, WASHC2 has undergone evolutionary duplication giving
rise to highly homologous family members (PubMed:19922874).
{ECO:0000305}.
-!- CAUTION: The function of the WASH complex is debated. One study
using partially purified samples reported a nucleation-promoting
factor (NPF) activity (PubMed:19922875). In another study, the
reconstituted and highly purified recombinant WASH core complex
did not show activity toward Arp2/3 complex suggesting a rather
inhibitory role towards WASH NPF activity (PubMed:20498093).
{ECO:0000305}.
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EMBL; AK289708; BAF82397.1; -; mRNA.
EMBL; AL928970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS78375.1; -.
RefSeq; NP_878908.4; NM_182905.4.
UniGene; Hs.446466; -.
UniGene; Hs.459573; -.
UniGene; Hs.461200; -.
UniGene; Hs.521961; -.
UniGene; Hs.585931; -.
UniGene; Hs.709408; -.
ProteinModelPortal; A8K0Z3; -.
BioGrid; 938833; 29.
ComplexPortal; CPX-1163; WASH complex, variant WASHC1/WASHC2C.
ComplexPortal; CPX-1172; WASH complex, variant WASHC1/WASHC2A.
CORUM; A8K0Z3; -.
IntAct; A8K0Z3; 14.
MINT; A8K0Z3; -.
TCDB; 9.A.3.1.2; the sorting nexin27 (snx27)-retromer assembly apparatus for recycling integral membrane proteins (snx27-retromeraa) family.
iPTMnet; A8K0Z3; -.
PhosphoSitePlus; A8K0Z3; -.
BioMuta; WASHC1; -.
jPOST; A8K0Z3; -.
MaxQB; A8K0Z3; -.
PRIDE; A8K0Z3; -.
ProteomicsDB; 1843; -.
DNASU; 100287171; -.
Ensembl; ENST00000442898; ENSP00000485627; ENSG00000181404.
GeneID; 100287171; -.
KEGG; hsa:100287171; -.
UCSC; uc010mgm.2; human.
CTD; 100287171; -.
DisGeNET; 100287171; -.
EuPathDB; HostDB:ENSG00000181404.15; -.
GeneCards; WASHC1; -.
H-InvDB; HIX0034804; -.
HGNC; HGNC:24361; WASHC1.
HPA; HPA002689; -.
MIM; 613632; gene.
neXtProt; NX_A8K0Z3; -.
OpenTargets; ENSG00000181404; -.
PharmGKB; PA162409121; -.
eggNOG; ENOG410IFZ4; Eukaryota.
eggNOG; ENOG410YN2V; LUCA.
GeneTree; ENSGT00390000016717; -.
HOVERGEN; HBG066686; -.
InParanoid; A8K0Z3; -.
KO; K18461; -.
OMA; PNLKGHA; -.
OrthoDB; 904881at2759; -.
PhylomeDB; A8K0Z3; -.
SIGNOR; A8K0Z3; -.
ChiTaRS; WASH1; human.
GenomeRNAi; 100287171; -.
PRO; PR:A8K0Z3; -.
Proteomes; UP000005640; Chromosome 9.
Bgee; ENSG00000181404; Expressed in 84 organ(s), highest expression level in right hemisphere of cerebellum.
ExpressionAtlas; A8K0Z3; baseline and differential.
Genevisible; A8K0Z3; HS.
GO; GO:0005776; C:autophagosome; ISS:ParkinsonsUK-UCL.
GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
GO; GO:0005829; C:cytosol; IEA:GOC.
GO; GO:0005769; C:early endosome; IDA:UniProtKB.
GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO; GO:0071437; C:invadopodium; IDA:UniProtKB.
GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0071203; C:WASH complex; IDA:UniProtKB.
GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO; GO:0043014; F:alpha-tubulin binding; IDA:UniProtKB.
GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IDA:UniProtKB.
GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
GO; GO:0006887; P:exocytosis; IMP:UniProtKB.
GO; GO:0022617; P:extracellular matrix disassembly; IMP:UniProtKB.
GO; GO:0010507; P:negative regulation of autophagy; ISS:ParkinsonsUK-UCL.
GO; GO:0043553; P:negative regulation of phosphatidylinositol 3-kinase activity; ISS:ParkinsonsUK-UCL.
GO; GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
GO; GO:0031274; P:positive regulation of pseudopodium assembly; IMP:UniProtKB.
GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO; GO:0031396; P:regulation of protein ubiquitination; ISS:ParkinsonsUK-UCL.
GO; GO:0042147; P:retrograde transport, endosome to Golgi; IDA:UniProtKB.
GO; GO:1990126; P:retrograde transport, endosome to plasma membrane; IMP:UniProtKB.
InterPro; IPR028290; WASH1.
InterPro; IPR021854; WASH1_WAHD.
PANTHER; PTHR23331; PTHR23331; 1.
Pfam; PF11945; WASH_WAHD; 1.
1: Evidence at protein level;
Actin-binding; Complete proteome; Cytoplasm; Cytoplasmic vesicle;
Cytoskeleton; Endosome; Isopeptide bond; Membrane; Protein transport;
Reference proteome; Transport; Ubl conjugation.
CHAIN 1 465 WASH complex subunit 1.
/FTId=PRO_0000329013.
DOMAIN 361 383 WH2.
REGION 1 167 WHD1.
REGION 1 54 Required for WASH complex assembly.
{ECO:0000250|UniProtKB:C4AMC7}.
REGION 349 465 VCA. {ECO:0000250|UniProtKB:C4AMC7}.
COMPBIAS 303 330 Pro-rich.
CROSSLNK 220 220 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000269|PubMed:23452853}.
MUTAGEN 220 220 K->R: Abolishes ubiquitination by the
TRIM27:MAGEL2 E3 ubiquitin ligase complex
and impairs retrograde transport.
{ECO:0000269|PubMed:23452853}.
MUTAGEN 463 463 W->A: Impairs retrograde transport from
endosome to Golgi apparatus.
{ECO:0000269|PubMed:19922874}.
CONFLICT 19 19 F -> L (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 54 54 Q -> R (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 98 98 G -> E (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 119 119 P -> S (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 141 141 D -> Y (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 245 245 H -> D (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 294 294 V -> A (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 302 302 T -> TAPP (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 321 321 P -> S (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 340 342 SSS -> GSN (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 362 362 W -> R (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 383 383 M -> V (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 391 392 QQ -> KK (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 407 407 H -> D (in Ref. 1; BAF82397).
{ECO:0000305}.
CONFLICT 439 439 V -> A (in Ref. 1; BAF82397).
{ECO:0000305}.
SEQUENCE 465 AA; 50328 MW; DBD5DEAFB7019B3E CRC64;
MTPVRMQHSL AGQTYAVPFI QPDLRREEAV QQMADALQYL QKVSGDIFSR ISQQVEQSRS
QVQAIGEKVS LAQAKIEKIK GSKKAIKVFS SAKYPAPGRL QEYGSIFTGA QDPGLQRRPR
HRIQSKHRPL DERALQEKLK DFPVCVSTKP EPEDDAEEGL GGLPSNISSV SSLLLFNTTE
NLYKKYVFLD PLAGAVTKTH VMLGAETEEK LFDAPLSISK REQLEQQVPE NYFYVPDLGQ
VPEIHVPSYL PDLPGIANDL MYSADLGPGI APSAPGTIPE LPTFHTEVAE PLKVDLQDGV
LTPPPPPPPP PPAPEVLASA PPLPPSTAAP VGQGARQDDS SSSASPSVQG APREVVDPSG
GWATLLESIR QAGGIGKAKL RSMKERKLEK QQQKEQEQVR ATSQGGHLMS DLFNKLVMRR
KGISGKGPGA GEGPGGAFVR VSDSIPPLPP PQQPQAEEDE DDWES


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Catalog number Product name Quantity
EIAAB46082 CXYorf1-like protein on chromosome 9,FAM39E,Homo sapiens,Human,Protein FAM39E,WAS protein family homolog 1,WASH1
EIAAB46087 CXYorf1-like protein on chromosome 2,FAM39B,Homo sapiens,Human,Protein FAM39B,WAS protein family homolog 2,WASH2P
EIAAB08144 Barren homolog protein 1,BRRN,BRRN1,CAPH,Chromosome-associated protein H,Condensin complex subunit 2,hCAP-H,Homo sapiens,Human,KIAA0074,NCAPH,Non-SMC condensin I complex subunit H,XCAP-H homolog
EIAAB08145 Barren homolog protein 1,Brrn,Brrn1,Caph,Chromosome-associated protein H,Condensin complex subunit 2,mCAP-H,Mouse,Mus musculus,Ncaph,Non-SMC condensin I complex subunit H,XCAP-H homolog
EIAAB46090 CXYorf1,FAM39A,Homo sapiens,Human,Protein FAM39A,WAS protein family homolog 6,WASH6P
EIAAB08150 CAP-G2,Chromosome-associated protein G2,Condensin-2 complex subunit G2,Leucine zipper protein 5,Luzp5,More than blood protein,Mouse,Mtb,Mus musculus,Ncapg2,Non-SMC condensin II complex subunit G2
EIAAB08142 CAPD2,Chromosome condensation-related SMC-associated protein 1,Chromosome-associated protein D2,CNAP1,Condensin complex subunit 1,hCAP-D2,Homo sapiens,Human,KIAA0159,NCAPD2,Non-SMC condensin I complex
EIAAB08143 Capd2,Chromosome condensation-related SMC-associated protein 1,Chromosome-associated protein D2,Cnap1,Condensin complex subunit 1,Kiaa0159,mCAP-D2,Mouse,Mus musculus,Ncapd2,Non-SMC condensin I complex
EIAAB11359 CBF5 homolog,DKC1,Dyskerin,H_ACA ribonucleoprotein complex subunit 4,Homo sapiens,Human,NOLA4,Nopp140-associated protein of 57 kDa,Nucleolar protein family A member 4,Nucleolar protein NAP57,snoRNP pr
EIAAB08149 CAP-G2,Chromosome-associated protein G2,Condensin-2 complex subunit G2,hCAP-G2,Homo sapiens,Human,Leucine zipper protein 5,LUZP5,NCAPG2,Non-SMC condensin II complex subunit G2
15-288-21448A AP-3 complex subunit beta-2 - Adapter-related protein complex 3 beta-2 subunit; Beta3B-adaptin; Adaptor protein complex AP-3 beta-2 subunit; AP-3 complex beta-2 subunit; Clathrin assembly protein comp 0.05 mg
15-288-21448A AP-3 complex subunit beta-2 - Adapter-related protein complex 3 beta-2 subunit; Beta3B-adaptin; Adaptor protein complex AP-3 beta-2 subunit; AP-3 complex beta-2 subunit; Clathrin assembly protein comp 0.1 mg
OBT1775 CSN1 (COP9 Signalosome Complex Subunit 1), COPS1 (COP9 Constitutive Photomorphogenic homolog Subunit 1), GPS1 (G Protein Pathway Surppressor 1), MFH protein Arabidopsis Fus6_Cop11 homolog, Rabbit ant 0.1 mg.
OBT1775 CSN1 (COP9 Signalosome Complex Subunit 1), COPS1 (COP9 Constitutive Photomorphogenic homolog Subunit 1), GPS1 (G Protein Pathway Surppressor 1), MFH protein Arabidopsis Fus6_Cop11 homolog, Rabbit ant 0.1 mg.
31-034 The protein encoded by CDC2 is a member of the Ser_Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF) 0.05 mg
EIAAB36200 Mouse,Mus musculus,Rasl10a,Ras-like protein family member 10A,Ras-like protein RRP22,Ras-related protein on chromosome 22 homolog,Rrp22
EIAAB08146 CAPG,Chromosome-associated protein G,Condensin complex subunit 3,Condensin subunit CAP-G,hCAP-G,Homo sapiens,Human,Melanoma antigen NY-MEL-3,NCAPG,Non-SMC condensin I complex subunit G,NYMEL3,XCAP-G h
EIAAB08152 CAPH2,Chromosome-associated protein H2,Condensin-2 complex subunit H2,hCAP-H2,Homo sapiens,Human,Kleisin-beta,NCAPH2,Non-SMC condensin II complex subunit H2
EIAAB42293 C22orf19,fSAP79,Functional spliceosome-associated protein 79,Homo sapiens,hTREX90,Human,KIAA0983,NF2_meningioma region protein pK1.3,Placental protein 39.2,PP39.2,THO complex subunit 5 homolog,THOC5
EIAAB27451 AD24,C10orf117,Factor for adipocyte differentiation 24,FAD24,Homo sapiens,Human,NOC3 protein homolog,NOC3L,NOC3-like protein,Nucleolar complex protein 3 homolog,Nucleolar complex-associated protein 3-
EIAAB27452 Ad24,Factor for adipocyte differentiation 24,Fad24,Mouse,Mus musculus,NOC3 protein homolog,Noc3l,NOC3-like protein,Nucleolar complex protein 3 homolog,Nucleolar complex-associated protein 3-like prote
EIAAB11361 Dkc1,Dyskerin,H_ACA ribonucleoprotein complex subunit 4,Mouse,Mus musculus,Nopp140-associated protein of 57 kDa,Nucleolar protein family A member 4,Nucleolar protein NAP57,snoRNP protein DKC1
EIAAB33317 Complex III subunit 9,Complex III subunit X,Cytochrome b-c1 complex subunit 9,Cytochrome c1 non-heme 7 kDa protein,Homo sapiens,HSPC119,Human,Ubiquinol-cytochrome c reductase complex 7.2 kDa protein,U
EIAAB45902 ESCRT-I complex subunit VPS37D,Mouse,Mus musculus,Vacuolar protein sorting-associated protein 37D,Vps37d,Wbscr24,Williams-Beuren syndrome region protein 24 homolog
EIAAB13662 CFBP,CIN85_CD2AP family-binding protein,ESCRT-I complex subunit MVB12A,FAM125A,Homo sapiens,Human,Multivesicular body subunit 12A,Protein FAM125A

Kits Elisa; taq POLYMERASE

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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP1566: Citrate cycle (TCA cycle)
WP1644: DNA replication
WP1663: Homologous recombination
WP1672: Mismatch repair
WP1693: Purine metabolism
WP1694: Pyrimidine metabolism
WP1909: Signal regulatory protein (SIRP) family interactions
WP2292: Chemokine signaling pathway
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism

Related Genes :
[WASHC1 FAM39E WASH1] WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1)
[WASH6P CXYorf1 FAM39A] WAS protein family homolog 6 (Protein FAM39A)
[WASH2P FAM39B] WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B)
[Washc1 Orf19 Wash Wash1] WASH complex subunit 1 (WAS protein family homolog 1)
[WASH3P FAM39DP] Putative WAS protein family homolog 3 (Protein FAM39DP)
[WASHC4 KIAA1033] WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP)
[WASHC1 WASH1] WASH complex subunit 1 (WAS protein family homolog 1)
[WASHC5 KIAA0196] WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin)
[Washc1 Wash1 Wash2] WASH complex subunit 1 (WAS protein family homolog 1)
[WASHC2C FAM21C KIAA0592] WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF)
[MLLT3 AF9 YEATS3] Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[WASHC3 AD-016 CCDC53 CGI-116 x0009] WASH complex subunit 3 (Coiled-coil domain-containing protein 53)
[TAF14 ANC1 CST10 SWP29 TAF30 TFG3 YPL129W] Transcription initiation factor TFIID subunit 14 (Actin non-complementing mutant 1) (Chromosome stability protein 10) (SWI/SNF chromatin-remodeling complex subunit TAF14) (SWI/SNF complex 29 kDa subunit) (SWI/SNF complex subunit TAF14) (TBP-associated factor 14) (TBP-associated factor 30 kDa) (Transcription factor G 30 kDa subunit) (Transcription initiation factor TFIIF 30 kDa subunit)
[STH1 NPS1 YIL126W] Nuclear protein STH1/NPS1 (EC 3.6.4.12) (ATP-dependent helicase STH1) (Chromatin structure-remodeling complex protein STH1) (SNF2 homolog)
[Washc2 D6Wsu116e Fam21 Kiaa0592] WASH complex subunit 2
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[DNAJB11 EDJ ERJ3 HDJ9 PSEC0121 UNQ537/PRO1080] DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4)
[COPS6 CSN6 HVIP] COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
[KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[CRY2 PHH1 SEL20 At1g04400 F19P19.14] Cryptochrome-2 (Atcry2) (Blue light photoreceptor) (Protein PHR homolog 1) (AtPHH1) (Protein SUPPRESSOR OF elf3 20)
[Suv39h1 Suv39h] Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
[CSN5A AJH1 CSN5B At1g22920 F19G10.12] COP9 signalosome complex subunit 5a (Signalosome subunit 5a) (EC 3.4.-.-) (Jun activation domain-binding homolog 1)
[dim-5 29E8.110 NCU04402] Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase dim-5) (H3-K9-HMTase dim-5) (HKMT)
[RRS1 RCH2 RRS1-S RSH4 SLH1 WRKY52 At5g45260/At5g45270 K9E15.2/K9E15.3] Disease resistance protein RRS1 (Disease resistance protein RCH2) (Disease resistance protein SLH1) (Probable WRKY transcription factor 52) (Protein RPS4-homolog) (Protein SENSITIVE TO LOW HUMIDITY 1) (Resistance to Colletotrichum higginsianum 2 protein) (Resistance to Ralstonia solanacearum 1 protein) (WRKY DNA-binding protein 52)
[Ap1m1 Cltnm] AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)
[GPS1 COPS1 CSN1] COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)
[Washc5 Kiaa0196] WASH complex subunit 5 (WASH complex subunit strumpellin)
[AP1M1 CLTNM] AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)
[NAA10 ARD1 ARD1A TE2] N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10)

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