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WNT1-inducible-signaling pathway protein 1 (WISP-1) (CCN family member 4) (Wnt-1-induced secreted protein)

 CCN4_HUMAN              Reviewed;         367 AA.
O95388; A8KAG6; E7EMM5; Q5JBS6; Q5JBS7; Q5JBS8; Q9HCS3;
15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
17-JUN-2020, entry version 173.
RecName: Full=CCN family member 4 {ECO:0000305};
AltName: Full=WNT1-inducible-signaling pathway protein 1;
Short=WISP-1;
AltName: Full=Wnt-1-induced secreted protein;
Flags: Precursor;
Name=CCN4 {ECO:0000312|HGNC:HGNC:12769}; Synonyms=WISP1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Fetal kidney, and Lung;
PubMed=9843955; DOI=10.1073/pnas.95.25.14717;
Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J.,
Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L.,
Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J.,
Gurney A.L., Botstein D., Levine A.J.;
"WISP genes are members of the connective tissue growth factor family that
are up-regulated in wnt-1-transformed cells and aberrantly expressed in
human colon tumors.";
Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Gastric carcinoma;
PubMed=11571650; DOI=10.1038/sj.onc.1204723;
Tanaka S., Sugimachi K., Saeki H., Kinoshita J., Ohga T., Shimada M.,
Maehara Y., Sugimachi K.;
"A novel variant of WISP1 lacking a Von Willebrand type C module
overexpressed in scirrhous gastric carcinoma.";
Oncogene 20:5525-5532(2001).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5).
Li Z., Chiao P.J., Evans D.B.;
"Multiple alternatively spliced variants of WISP1 are overexpressed in
pancreatic cancer.";
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
TISSUE=Synovium, and Uterus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16421571; DOI=10.1038/nature04406;
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
Platzer M., Shimizu N., Lander E.S.;
"DNA sequence and analysis of human chromosome 8.";
Nature 439:331-335(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
FUNCTION IN WNT1 SIGNALING.
PubMed=10716946;
Xu L., Corcoran R.B., Welsh J.W., Pennica D., Levine A.J.;
"WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene.";
Genes Dev. 14:585-595(2000).
[9]
FUNCTION IN TP53-MEDIATED APOPTOSIS.
PubMed=11782444; DOI=10.1101/gad.942902;
Su F., Overholtzer M., Besser D., Levine A.J.;
"WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through
activation of the Akt kinase.";
Genes Dev. 16:46-57(2002).
[10]
INTERACTION WITH DECORIN AND BIGLYCAN.
PubMed=11598131; DOI=10.1074/jbc.m108339200;
Desnoyers L., Arnott D., Pennica D.;
"WISP-1 binds to decorin and biglycan.";
J. Biol. Chem. 276:47599-47607(2001).
-!- FUNCTION: Downstream regulator in the Wnt/Frizzled-signaling pathway.
Associated with cell survival. Attenuates p53-mediated apoptosis in
response to DNA damage through activation of AKT kinase. Up-regulates
the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma
fibroblasts. In vitro binding to skin fibroblasts occurs through the
proteoglycans, decorin and biglycan. {ECO:0000269|PubMed:10716946,
ECO:0000269|PubMed:11782444}.
-!- INTERACTION:
O95388; P49639: HOXA1; NbExp=5; IntAct=EBI-1050638, EBI-740785;
O95388; P32242: OTX1; NbExp=3; IntAct=EBI-1050638, EBI-740446;
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Name=1;
IsoId=O95388-1; Sequence=Displayed;
Name=2; Synonyms=WISP1v;
IsoId=O95388-2; Sequence=VSP_008008, VSP_008009;
Name=3;
IsoId=O95388-3; Sequence=VSP_042010;
Name=4;
IsoId=O95388-4; Sequence=VSP_045958, VSP_045959;
Name=5;
IsoId=O95388-5; Sequence=VSP_047706, VSP_047707;
-!- TISSUE SPECIFICITY: Expressed in heart, kidney, lung, pancreas,
placenta, ovary, small intestine and spleen. Isoform 2 is expressed
predominantly in scirrhous gastric carcinoma and, weakly in placenta.
Overexpression is associated with several cancers including breast
cancer and colon tumors. Isoform 2 is overexpressed in scirrhous
gastric carcinoma.
-!- SIMILARITY: Belongs to the CCN family. {ECO:0000305}.
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EMBL; AF100779; AAC96321.1; -; mRNA.
EMBL; AB034725; BAB17849.1; -; mRNA.
EMBL; AY196486; AAP43924.1; -; mRNA.
EMBL; AY196487; AAP43925.1; -; mRNA.
EMBL; AY196488; AAP43926.1; -; mRNA.
EMBL; AK293031; BAF85720.1; -; mRNA.
EMBL; AK301508; BAG63017.1; -; mRNA.
EMBL; AF192304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471060; EAW92162.1; -; Genomic_DNA.
EMBL; BC074840; AAH74840.1; -; mRNA.
EMBL; BC074841; AAH74841.1; -; mRNA.
CCDS; CCDS56555.1; -. [O95388-4]
CCDS; CCDS56556.1; -. [O95388-3]
CCDS; CCDS6371.1; -. [O95388-1]
CCDS; CCDS6372.1; -. [O95388-2]
RefSeq; NP_001191798.1; NM_001204869.1. [O95388-4]
RefSeq; NP_001191799.1; NM_001204870.1. [O95388-3]
RefSeq; NP_003873.1; NM_003882.3. [O95388-1]
RefSeq; NP_543028.1; NM_080838.2. [O95388-2]
SMR; O95388; -.
BioGRID; 114367; 2.
IntAct; O95388; 3.
MINT; O95388; -.
STRING; 9606.ENSP00000250160; -.
iPTMnet; O95388; -.
PhosphoSitePlus; O95388; -.
BioMuta; WISP1; -.
MassIVE; O95388; -.
PaxDb; O95388; -.
PeptideAtlas; O95388; -.
PRIDE; O95388; -.
ProteomicsDB; 16974; -.
ProteomicsDB; 50837; -. [O95388-1]
ProteomicsDB; 50838; -. [O95388-2]
ProteomicsDB; 50839; -. [O95388-3]
ProteomicsDB; 62990; -.
Antibodypedia; 1567; 325 antibodies.
DNASU; 8840; -.
Ensembl; ENST00000220856; ENSP00000220856; ENSG00000104415. [O95388-2]
Ensembl; ENST00000250160; ENSP00000250160; ENSG00000104415. [O95388-1]
Ensembl; ENST00000517423; ENSP00000427744; ENSG00000104415. [O95388-4]
Ensembl; ENST00000519433; ENSP00000429185; ENSG00000104415. [O95388-3]
GeneID; 8840; -.
KEGG; hsa:8840; -.
UCSC; uc003yub.4; human. [O95388-1]
CTD; 8840; -.
DisGeNET; 8840; -.
EuPathDB; HostDB:ENSG00000104415.13; -.
GeneCards; CCN4; -.
HGNC; HGNC:12769; CCN4.
HPA; ENSG00000104415; Low tissue specificity.
MIM; 603398; gene.
neXtProt; NX_O95388; -.
OpenTargets; ENSG00000104415; -.
PharmGKB; PA37372; -.
eggNOG; ENOG410IH8M; Eukaryota.
eggNOG; ENOG410ZWR5; LUCA.
GeneTree; ENSGT00940000158587; -.
HOGENOM; CLU_063247_3_1_1; -.
InParanoid; O95388; -.
KO; K22471; -.
OMA; GENCTEA; -.
OrthoDB; 601212at2759; -.
PhylomeDB; O95388; -.
TreeFam; TF326070; -.
SIGNOR; O95388; -.
BioGRID-ORCS; 8840; 1 hit in 779 CRISPR screens.
ChiTaRS; WISP1; human.
GeneWiki; WNT1-inducible-signaling_pathway_protein_1; -.
GenomeRNAi; 8840; -.
Pharos; O95388; Tbio.
PRO; PR:O95388; -.
Proteomes; UP000005640; Chromosome 8.
RNAct; O95388; protein.
Bgee; ENSG00000104415; Expressed in metanephros and 123 other tissues.
ExpressionAtlas; O95388; baseline and differential.
Genevisible; O95388; HS.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0008201; F:heparin binding; IBA:GO_Central.
GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
GO; GO:0005178; F:integrin binding; IBA:GO_Central.
GO; GO:0060348; P:bone development; IEA:Ensembl.
GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IDA:UniProtKB.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IMP:UniProtKB.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; ISS:UniProtKB.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
GO; GO:0090303; P:positive regulation of wound healing; IEA:Ensembl.
GO; GO:0050707; P:regulation of cytokine secretion; IDA:UniProtKB.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
Gene3D; 2.20.100.10; -; 1.
InterPro; IPR006207; Cys_knot_C.
InterPro; IPR006208; Glyco_hormone_CN.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR000867; IGFBP-like.
InterPro; IPR012395; IGFBP_CNN.
InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
InterPro; IPR000884; TSP1_rpt.
InterPro; IPR036383; TSP1_rpt_sf.
InterPro; IPR001007; VWF_dom.
Pfam; PF00007; Cys_knot; 1.
Pfam; PF00219; IGFBP; 1.
Pfam; PF00090; TSP_1; 1.
Pfam; PF00093; VWC; 1.
PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
SMART; SM00041; CT; 1.
SMART; SM00121; IB; 1.
SMART; SM00209; TSP1; 1.
SMART; SM00214; VWC; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF82895; SSF82895; 1.
PROSITE; PS01185; CTCK_1; 1.
PROSITE; PS01225; CTCK_2; 1.
PROSITE; PS00222; IGFBP_N_1; 1.
PROSITE; PS51323; IGFBP_N_2; 1.
PROSITE; PS50092; TSP1; 1.
PROSITE; PS01208; VWFC_1; 1.
PROSITE; PS50184; VWFC_2; 1.
1: Evidence at protein level;
Alternative splicing; Cell adhesion; Disulfide bond; Glycoprotein;
Polymorphism; Proto-oncogene; Reference proteome; Secreted; Signal;
Wnt signaling pathway.
SIGNAL 1..22
/evidence="ECO:0000255"
CHAIN 23..367
/note="CCN family member 4"
/id="PRO_0000014406"
DOMAIN 40..118
/note="IGFBP N-terminal"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
DOMAIN 121..186
/note="VWFC"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
DOMAIN 215..260
/note="TSP type-1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
DOMAIN 273..347
/note="CTCK"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
CARBOHYD 86
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 143
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 284
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 343
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 273..310
/evidence="ECO:0000250"
DISULFID 290..324
/evidence="ECO:0000250"
DISULFID 301..340
/evidence="ECO:0000250"
DISULFID 304..342
/evidence="ECO:0000250"
DISULFID 309..346
/evidence="ECO:0000250"
VAR_SEQ 1..31
/note="MRWFLPWTLAAVTAAAASTVLATALSPAPTT -> MPVPLTSRHEVVPALDA
GSSDSSSRQHRPGH (in isoform 5)"
/evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.3"
/id="VSP_047706"
VAR_SEQ 24..268
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|Ref.3"
/id="VSP_042010"
VAR_SEQ 32..203
/note="Missing (in isoform 5)"
/evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.3"
/id="VSP_047707"
VAR_SEQ 117..155
/note="QVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTP -> RREEVSGCV
PARGIHELHTCGLHQHTLLSTQVLWSLHGQ (in isoform 4)"
/evidence="ECO:0000303|Ref.3"
/id="VSP_045958"
VAR_SEQ 117
/note="Q -> H (in isoform 2)"
/evidence="ECO:0000303|PubMed:11571650"
/id="VSP_008008"
VAR_SEQ 118..204
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:11571650"
/id="VSP_008009"
VAR_SEQ 156..367
/note="Missing (in isoform 4)"
/evidence="ECO:0000303|Ref.3"
/id="VSP_045959"
VARIANT 205
/note="A -> S (in dbSNP:rs35513885)"
/id="VAR_061265"
CONFLICT 91
/note="A -> V (in Ref. 3; AAP43926)"
/evidence="ECO:0000305"
CONFLICT O95388-4:155
/note="Q -> QQVLHPLQV (in Ref. 3; AAP43926)"
/evidence="ECO:0000305"
SEQUENCE 367 AA; 40331 MW; 9F29CA94D69C0502 CRC64;
MRWFLPWTLA AVTAAAASTV LATALSPAPT TMDFTPAPLE DTSSRPQFCK WPCECPPSPP
RCPLGVSLIT DGCECCKMCA QQLGDNCTEA AICDPHRGLY CDYSGDRPRY AIGVCAQVVG
VGCVLDGVRY NNGQSFQPNC KYNCTCIDGA VGCTPLCLRV RPPRLWCPHP RRVSIPGHCC
EQWVCEDDAK RPRKTAPRDT GAFDAVGEVE AWHRNCIAYT SPWSPCSTSC GLGVSTRISN
VNAQCWPEQE SRLCNLRPCD VDIHTLIKAG KKCLAVYQPE ASMNFTLAGC ISTRSYQPKY
CGVCMDNRCC IPYKSKTIDV SFQCPDGLGF SRQVLWINAC FCNLSCRNPN DIFADLESYP
DFSEIAN


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EM207 WNT1-inducible-signaling pathway protein 1 Elisa Kit 96T
EH928 WNT1-inducible-signaling pathway protein 3 Elisa Kit 96T
EH1267 WNT1-inducible-signaling pathway protein 1 Elisa Kit 96T
EM734 WNT1-inducible-signaling pathway protein 2 Elisa Kit 96T
EH330 WNT1-inducible-signaling pathway protein 1 Elisa Kit 96T
UB-E10419 Rat WNT1 Inducible Signaling Pathway Protein 2(WISP2)ELISA Kit 96T
E07W0001 Porcine WNT1 Inducible Signaling Pathway Protein 1 ELISA 96T/kit
UB-E10420 Rat WNT1 Inducible Signaling Pathway Protein 1(WISP1)ELISA Kit 96T
E12412033 Rat WNT1 Inducible Signaling Pathway Protein 2 (WISP2) ELISA Kit 1
Pathways :
WP2203: TSLP Signaling Pathway
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP211: BMP signaling pathway
WP2032: TSH signaling pathway
WP428: Wnt Signaling Pathway
WP375: Wnt Signaling Pathway NetPath
WP1288: Wnt Signaling Pathway and Pluripotency
WP1135: Wnt Signaling Pathway
WP754: Wnt Signaling Pathway NetPath
WP35: G Protein Signaling Pathways
WP1010: Wnt Signaling Pathway and Pluripotency
WP1344: Wnt Signaling Pathway and Pluripotency
WP73: G Protein Signaling Pathways
WP893: Wnt Signaling Pathway and Pluripotency
WP1371: G Protein Signaling Pathways
WP230: TGF Beta Signaling Pathway
WP232: G Protein Signaling Pathways
WP931: G Protein Signaling Pathways
WP564: Wnt Signaling Pathway
WP403: Wnt Signaling Pathway
WP113: TGF Beta Signaling Pathway
WP813: G Protein Signaling Pathways
WP723: Wnt Signaling Pathway and Pluripotency
WP1165: G Protein Signaling Pathways

Related Genes :
[Ccn6 Wisp3] Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3)
[cwn-1 wnt-1 K10B4.6] Protein Wnt-1
[RHOU ARHU CDC42L1 G28K WRCH1 SB128] Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
[Rhou Arhu G28k Wrch1] Rho-related GTP-binding protein RhoU (Rho GTPase-like protein ARHU) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
[CCN3 IGFBP9 NOV NOVH] CCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
[Ccn3 Nov] CCN family member 3 (Cellular communication network factor 3) (Nephroblastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
[CCN2 CTGF HCS24 IGFBP8] CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)
[Ccn3 Nov] CCN family member 3 (Cellular communication network factor 3) (Nephroblastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
[WNT10B WNT12] Protein Wnt-10b (Protein Wnt-12)
[FERMT2 KIND2 MIG2 PLEKHC1] Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)
[IFITM1 CD225 IFI17] Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225)
[CCL4 LAG1 MIP1B SCYA4] C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
[Ifitm3] Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1)
[SFRP1 FRP FRP1 SARP2] Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)
[wnt5b wnt-5 wnt5 wnt5a si:ch73-211c7.1] Protein Wnt-5b
[TNFSF18 AITRL GITRL TL6 UNQ149/PRO175] Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)
[GPRC5B RAIG2] G-protein coupled receptor family C group 5 member B (A-69G12.1) (Retinoic acid-induced gene 2 protein) (RAIG-2)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[cwn-2 wnt-2 W01B6.1] Protein Wnt-2
[Ddit4 Dig2 Redd1 Rtp801] DNA damage-inducible transcript 4 protein (Dexamethasone-induced gene 2 protein) (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)
[WNT9B WNT14B WNT15 UNQ6973/PRO21956] Protein Wnt-9b (Protein Wnt-14b) (Protein Wnt-15)
[Enpp1 Npps Pc1 Pdnp1] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Lymphocyte antigen 41) (Ly-41) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
[ENPP1 M6S1 NPPS PC1 PDNP1] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
[Wnt5a Wnt-5a] Protein Wnt-5a
[Enpp1 Npps Pc1 Pdnp1] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
[Sfrp1] Secreted frizzled-related protein 1 (sFRP-1)
[Wnt5a Wnt-5a] Protein Wnt-5a
[SFRP1 FRZA] Secreted frizzled-related protein 1 (sFRP-1) (Frizzled in aorta protein) (FrzA protein)
[Sfrp1] Secreted frizzled-related protein 1 (sFRP-1) (Fragment)
[WNT3A] Protein Wnt-3a

Bibliography :