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Zinc transporter 9 (ZnT-9) (Human embryonic lung protein) (HuEL) (Solute carrier family 30 member 9)

 ZNT9_HUMAN              Reviewed;         568 AA.
Q6PML9; Q4W5B6; Q7Z5I7; Q8TBB2; Q9Y6R2;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
13-FEB-2019, entry version 126.
RecName: Full=Zinc transporter 9;
Short=ZnT-9;
AltName: Full=Human embryonic lung protein {ECO:0000303|PubMed:10409434};
Short=HuEL {ECO:0000303|PubMed:10409434};
AltName: Full=Solute carrier family 30 member 9;
Name=SLC30A9; Synonyms=C4orf1, HUEL;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
AND VARIANTS VAL-50 AND ALA-97.
TISSUE=Lung;
PubMed=10409434; DOI=10.1006/geno.1999.5856;
Sim D.L.C., Chow V.T.K.;
"The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and
encodes a nuclear protein containing the nuclear receptor interaction
motif.";
Genomics 59:224-233(1999).
[2]
SEQUENCE REVISION TO 160; 174 AND 196.
TISSUE=Lung;
Chow V.T.K., Sim D.L.C.;
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-50 AND ALA-97.
TISSUE=Testis;
Xu Z.Y., Huang X.Y., Xu M., Yin L.L., Lu L., Li J.M., Zhou Z.M.,
Sha J.H.;
"A human HUEL (C4orf1) isoform play the role in spermatogenesis.";
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA].
Luo W., Sedehizade F., Hanck T., Reiser G.;
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-50 AND
ALA-97.
TISSUE=Cervix, Colon, and Muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[9]
STRUCTURE BY NMR OF 124-217.
RIKEN structural genomics initiative (RSGI);
"Solution structure of a putative DNA-binding domain of the human
solute carrier family 30 (zinc transporter) protein.";
Submitted (FEB-2009) to the PDB data bank.
[10]
INVOLVEMENT IN BILAPES, VARIANT BILAPES ALA-350 DEL, CHARACTERIZATION
OF VARIANT BILAPES ALA-350 DEL, TISSUE SPECIFICITY, SUBCELLULAR
LOCATION, AND FUNCTION.
PubMed=28334855; DOI=10.1093/brain/awx013;
Perez Y., Shorer Z., Liani-Leibson K., Chabosseau P., Kadir R.,
Volodarsky M., Halperin D., Barber-Zucker S., Shalev H., Schreiber R.,
Gradstein L., Gurevich E., Zarivach R., Rutter G.A., Landau D.,
Birk O.S.;
"SLC30A9 mutation affecting intracellular zinc homeostasis causes a
novel cerebro-renal syndrome.";
Brain 140:928-939(2017).
-!- FUNCTION: Acts as a zinc transporter involved in intracellular
zinc homeostasis (PubMed:28334855). Functions as a secondary
coactivator for nuclear receptors by cooperating with p160
coactivators subtypes. Plays a role in transcriptional activation
of Wnt-responsive genes (By similarity).
{ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855}.
-!- SUBUNIT: Interacts with GRIP1, ESR1 and AR.
{ECO:0000250|UniProtKB:Q5IRJ6}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:10409434}.
Cytoplasm {ECO:0000269|PubMed:10409434}. Cytoplasmic vesicle
{ECO:0000269|PubMed:28334855}. Endoplasmic reticulum
{ECO:0000269|PubMed:28334855}. Note=Mainly in the cytoplasm
(PubMed:10409434). Partial co-localization with endoplasmic
reticulum (PubMed:28334855). {ECO:0000269|PubMed:10409434,
ECO:0000269|PubMed:28334855}.
-!- TISSUE SPECIFICITY: Ubiquitously expressed in fetal and adult
tissues and cancer cell lines. {ECO:0000269|PubMed:10409434,
ECO:0000269|PubMed:28334855}.
-!- DISEASE: Birk-Landau-Perez syndrome (BILAPES) [MIM:617595]: An
autosomal recessive syndrome characterized by early-childhood
onset of different combinations of intellectual disability, muscle
weakness, camptocormia, oculomotor apraxia, and nephropathy.
{ECO:0000269|PubMed:28334855}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAP83846.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};
Sequence=AAY40966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF006621; AAB87763.2; -; mRNA.
EMBL; AY319413; AAP83846.1; ALT_SEQ; mRNA.
EMBL; AY594282; AAT02479.1; -; mRNA.
EMBL; AC113151; AAY40966.1; ALT_SEQ; Genomic_DNA.
EMBL; BC007732; AAH07732.1; -; mRNA.
EMBL; BC016949; AAH16949.1; -; mRNA.
EMBL; BC022981; AAH22981.1; -; mRNA.
CCDS; CCDS3465.1; -.
RefSeq; NP_006336.3; NM_006345.3.
UniGene; Hs.479634; -.
PDB; 2ENK; NMR; -; A=124-217.
PDBsum; 2ENK; -.
ProteinModelPortal; Q6PML9; -.
SMR; Q6PML9; -.
BioGrid; 115726; 20.
IntAct; Q6PML9; 6.
MINT; Q6PML9; -.
STRING; 9606.ENSP00000264451; -.
TCDB; 2.A.4.6.1; the cation diffusion facilitator (cdf) family.
iPTMnet; Q6PML9; -.
PhosphoSitePlus; Q6PML9; -.
BioMuta; SLC30A9; -.
DMDM; 74722746; -.
EPD; Q6PML9; -.
jPOST; Q6PML9; -.
MaxQB; Q6PML9; -.
PaxDb; Q6PML9; -.
PeptideAtlas; Q6PML9; -.
PRIDE; Q6PML9; -.
ProteomicsDB; 67254; -.
Ensembl; ENST00000264451; ENSP00000264451; ENSG00000014824.
GeneID; 10463; -.
KEGG; hsa:10463; -.
UCSC; uc003gwl.4; human.
CTD; 10463; -.
DisGeNET; 10463; -.
EuPathDB; HostDB:ENSG00000014824.13; -.
GeneCards; SLC30A9; -.
H-InvDB; HIX0004181; -.
HGNC; HGNC:1329; SLC30A9.
HPA; HPA004014; -.
MalaCards; SLC30A9; -.
MIM; 604604; gene.
MIM; 617595; phenotype.
neXtProt; NX_Q6PML9; -.
OpenTargets; ENSG00000014824; -.
Orphanet; 505242; Psychomotor regression-oculomotor apraxia-movement disorder-nephropathy syndrome.
PharmGKB; PA25909; -.
eggNOG; KOG2802; Eukaryota.
eggNOG; COG0053; LUCA.
GeneTree; ENSGT00390000008346; -.
HOGENOM; HOG000242618; -.
HOVERGEN; HBG104893; -.
InParanoid; Q6PML9; -.
KO; K14696; -.
OMA; KKREYGP; -.
OrthoDB; 667718at2759; -.
PhylomeDB; Q6PML9; -.
TreeFam; TF314526; -.
SIGNOR; Q6PML9; -.
ChiTaRS; SLC30A9; human.
EvolutionaryTrace; Q6PML9; -.
GenomeRNAi; 10463; -.
PRO; PR:Q6PML9; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000014824; Expressed in 239 organ(s), highest expression level in forebrain.
ExpressionAtlas; Q6PML9; baseline and differential.
Genevisible; Q6PML9; HS.
GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
GO; GO:0005856; C:cytoskeleton; IDA:UniProtKB.
GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISM:NTNU_SB.
GO; GO:0016922; F:nuclear receptor binding; IBA:GO_Central.
GO; GO:0030374; F:nuclear receptor transcription coactivator activity; IBA:GO_Central.
GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:UniProtKB.
GO; GO:0006289; P:nucleotide-excision repair; TAS:BHF-UCL.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0006829; P:zinc ion transport; IMP:UniProtKB.
Gene3D; 1.20.1510.10; -; 1.
Gene3D; 3.90.530.10; -; 1.
InterPro; IPR002524; Cation_efflux.
InterPro; IPR027469; Cation_efflux_TMD_sf.
InterPro; IPR009061; DNA-bd_dom_put_sf.
InterPro; IPR040177; SLC30A9.
InterPro; IPR037129; XPA_sf.
PANTHER; PTHR13414; PTHR13414; 1.
Pfam; PF01545; Cation_efflux; 1.
SUPFAM; SSF161111; SSF161111; 1.
SUPFAM; SSF46955; SSF46955; 1.
TIGRFAMs; TIGR01297; CDF; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytoplasm; Cytoplasmic vesicle;
Disease mutation; Endoplasmic reticulum; Ion transport; Membrane;
Nucleus; Polymorphism; Reference proteome; Transcription;
Transcription regulation; Transmembrane; Transmembrane helix;
Transport; Zinc; Zinc transport.
CHAIN 1 568 Zinc transporter 9.
/FTId=PRO_0000295805.
TRANSMEM 239 259 Helical. {ECO:0000255}.
TRANSMEM 314 334 Helical. {ECO:0000255}.
TRANSMEM 342 362 Helical. {ECO:0000255}.
TRANSMEM 392 412 Helical. {ECO:0000255}.
TRANSMEM 424 444 Helical. {ECO:0000255}.
MOTIF 462 466 LXXLL motif.
VARIANT 50 50 M -> V (in dbSNP:rs1047626).
{ECO:0000269|PubMed:10409434,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.3}.
/FTId=VAR_052003.
VARIANT 97 97 T -> A (in dbSNP:rs2581423).
{ECO:0000269|PubMed:10409434,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.3}.
/FTId=VAR_052004.
VARIANT 350 350 Missing (in BILAPES; no effect on Wnt-
signaling; no change in cytoplasmic
vesicle subcellular location; decrease in
cytosolic free zinc levels).
{ECO:0000269|PubMed:28334855}.
/FTId=VAR_079365.
VARIANT 353 353 L -> S (in dbSNP:rs1801962).
/FTId=VAR_052005.
CONFLICT 141 141 C -> Y (in Ref. 3; AAP83846).
{ECO:0000305}.
CONFLICT 356 356 E -> V (in Ref. 3; AAP83846).
{ECO:0000305}.
CONFLICT 401 401 V -> A (in Ref. 6; AAH22981).
{ECO:0000305}.
STRAND 129 132 {ECO:0000244|PDB:2ENK}.
HELIX 133 139 {ECO:0000244|PDB:2ENK}.
HELIX 144 149 {ECO:0000244|PDB:2ENK}.
STRAND 167 169 {ECO:0000244|PDB:2ENK}.
HELIX 170 180 {ECO:0000244|PDB:2ENK}.
STRAND 181 183 {ECO:0000244|PDB:2ENK}.
HELIX 184 209 {ECO:0000244|PDB:2ENK}.
SEQUENCE 568 AA; 63515 MW; CA59839CA983FDC2 CRC64;
MLPGLAAAAA HRCSWSSLCR LRLRCRAAAC NPSDRQEWQN LVTFGSFSNM VPCSHPYIGT
LSQVKLYSTN VQKEGQGSQT LRVEKVPSFE TAEGIGTELK APLKQEPLQV RVKAVLKKRE
YGSKYTQNNF ITGVRAINEF CLKSSDLEQL RKIRRRSPHE DTESFTVYLR SDVEAKSLEV
WGSPEALARE KKLRKEAEIE YRERLFRNQK ILREYRDFLG NTKPRSRTAS VFFKGPGKVV
MVAICINGLN CFFKFLAWIY TGSASMFSEA IHSLSDTCNQ GLLALGISKS VQTPDPSHPY
GFSNMRYISS LISGVGIFMM GAGLSWYHGV MGLLHPQPIE SLLWAYCILA GSLVSEGATL
LVAVNELRRN ARAKGMSFYK YVMESRDPST NVILLEDTAA VLGVIIAATC MGLTSITGNP
LYDSLGSLGV GTLLGMVSAF LIYTNTEALL GRSIQPEQVQ RLTELLENDP SVRAIHDVKA
TDLGLGKVRF KAEVDFDGRV VTRSYLEKQD FDQMLQEIQE VKTPEELETF MLKHGENIID
TLGAEVDRLE KELKKRNPEV RHVDLEIL


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Pathways :
WP2199: Seed Development
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1616: ABC transporters
WP1689: Porphyrin and chlorophyll metabolism
WP1713: Two-component system
WP1909: Signal regulatory protein (SIRP) family interactions
WP211: BMP signaling pathway
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1411: Cell Division: First embryonic mitosis
WP1438: Influenza A virus infection
WP1455: Serotonin Transporter Activity
WP1485: Interactions between CFTR and other ion channels
WP1487: TNF-alpha and mucus production in lung epythelium
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation

Related Genes :
[SLC30A8 ZNT8] Zinc transporter 8 (ZnT-8) (Solute carrier family 30 member 8)
[SLC30A2 ZNT2] Zinc transporter 2 (ZnT-2) (Solute carrier family 30 member 2)
[Slc30a8 Znt8] Zinc transporter 8 (ZnT-8) (Solute carrier family 30 member 8)
[SLC30A7 ZNT7 ZNTL2] Zinc transporter 7 (ZnT-7) (Solute carrier family 30 member 7) (Znt-like transporter 2)
[SLC26A9] Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9)
[Slc30a8 Znt8] Zinc transporter 8 (ZnT-8) (Solute carrier family 30 member 8)
[SLC9B2 NHA2 NHEDC2] Sodium/hydrogen exchanger 9B2 (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2)
[SLC22A18 BWR1A BWSCR1A HET IMPT1 ITM ORCTL2 SLC22A1L TSSC5] Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)
[SLC9A1 APNH1 NHE1] Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
[SLC39A1 IRT1 ZIP1 ZIRTL CGI-08 CGI-71] Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1)
[SLC9A9 NHE9 Nbla00118] Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9)
[ABCB9 KIAA1520] ATP-binding cassette sub-family B member 9 (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL)
[SLC6A9] Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)
[SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6] Solute carrier organic anion transporter family member 1B1 (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
[DNAJB11 EDJ ERJ3 HDJ9 PSEC0121 UNQ537/PRO1080] DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4)
[SLC2A6 GLUT9] Solute carrier family 2, facilitated glucose transporter member 6 (Glucose transporter type 6) (GLUT-6) (Glucose transporter type 9) (GLUT-9)
[SLC2A1 GLUT1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
[SLC25A25 APC3 KIAA1896 MCSC3 SCAMC2 UNQ549/PRO1106] Calcium-binding mitochondrial carrier protein SCaMC-2 (Mitochondrial ATP-Mg/Pi carrier protein 3) (Mitochondrial Ca(2+)-dependent solute carrier protein 3) (Small calcium-binding mitochondrial carrier protein 2) (Solute carrier family 25 member 25)
[SLC39A8 BIGM103 ZIP8 PP3105] Zinc transporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)
[SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8] Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
[SLC35F6 C2orf18 UNQ3047/PRO9863] Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog)
[SLCO4C1 OATP4C1 OATPX SLC21A20] Solute carrier organic anion transporter family member 4C1 (OATP-H) (Organic anion transporter M1) (OATP-M1) (Solute carrier family 21 member 20)
[Slc26a9] Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9)
[SLC22A5 OCTN2] Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2)
[RDH5 HSD17B9 RDH1 SDR9C5] 11-cis retinol dehydrogenase (11-cis RDH) (11-cis RoDH) (EC 1.1.1.315) (9-cis retinol dehydrogenase) (9cRDH) (Retinol dehydrogenase 5) (Short chain dehydrogenase/reductase family 9C member 5)
[SLC9A3 NHE3] Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)
[SLC9A3R1 NHERF NHERF1] Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
[SLC23A1 SVCT1 YSPL3] Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)
[KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[SLC38A2 ATA2 KIAA1382 SAT2 SNAT2] Sodium-coupled neutral amino acid transporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)

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