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Index / Ray Biotech / Mouse Anti-Human Dectin-1, Low Endotoxin /Product Detail : 129-10237 Mouse Anti-Human Dectin-1, Low Endotoxin
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#129-10237 Mouse Anti-Human Dectin-1, Low Endotoxin

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  Price : 920   EUR
1044   USD
713   GBP
3864   Zloty
123100   JPY
7095   NOK
7602   SEK
1040   CHF

Product name : Mouse Anti-Human Dectin-1, Low Endotoxin

Catalog number : 129-10237

Quantity: 500

Availability: Yes

Supplier name : Ray Biotech

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About this Product :

Mouse Anti-Human Dectin-1, Low Endotoxin antibody storage Gentaur recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Mouse Anti-Human Dectin-1, Low Endotoxin.
http://mybiofast.com/ver.php?search=anti-&submit=Search

Mouse Anti-Human Dectin-1, Low Endotoxin storing antibdies for longer storage periods of the Mouse Anti-Human Dectin-1, Low Endotoxin we recommend - 21C or lower and for short periods lees than 1 month we suggest +5C fridge temperatures.
http://mybiofast.com/ver.php?search=antibodie&submit=Search

Mouse Anti-Human Dectin-1, Low Endotoxin Human samples 80 % of the research is conducted on human samples. Gentaur suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Mouse Anti-Human Dectin-1, Low Endotoxin.
http://mybiofast.com/ver.php?search=human+&submit=Search

More Details about

 

Target Name

Dectin-1

Target Species

Human

Application Notes

Recommended Applications
Flow Cytometry, Functional Assays

Specificity

This product recognizes human Dectin-1, also known as beta-glucan receptor (βGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells.

Human Dectin-1 has two major (βGR-A and βGR-B) and several minor isoforms. βGR-A and βGR-B differs by the presence and absence, respectively, of a stalk region. This antibody recognizes both of these isoforms. This product could be used to inhibit receptor function.

Storage/Stability

Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Quality Control (Contaminants):
<0.01EU/ug
Format Type:
Low Endotoxin

Concentration

IgG concentration 1.0mg/ml

Preparation

Immunogen:
NIH3T3 cells expressing full length Beta-glucan receptor.
Preservative:
None present
This product
Spleen cells from immunised C57BL/6 mice were fused with cells of the murine SP2 myeloma cell line.

Purification

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

 
 
 
 
 

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY. Not for diagnostic or therapeutic use.

 

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Pathways :
WP100: Glutathione metabolism
WP1016: Wnt Signaling Pathway
WP1039: Glutathione metabolism
WP104: Alanine and aspartate metabolism
WP1056: Complement and Coagulation Cascades
WP106: Alanine and aspartate metabolism
WP1126: Tryptophan metabolism
WP1135: Wnt Signaling Pathway
WP1172: Complement and Coagulation Cascades
WP1313: Insulin Signaling
WP1315: IL-5 Signaling Pathway
WP1318: Eicosanoid Synthesis
WP1321: Myometrial Relaxation and Contraction Pathways
WP1323: EGFR1 Signaling Pathway
WP1330: estrogen signalling
WP1331: Adipogenesis
WP1333: Hypothetical Network for Drug Addiction
WP1337: MAPK signaling pathway
WP1338: Peptide GPCRs
WP1339: Electron Transport Chain
WP1345: T Cell Receptor Signaling Pathway
WP1347: Triacylglyceride Synthesis
WP1349: Wnt Signaling Pathway
WP1350: Type II interferon signaling (IFNG)
WP1351: Apoptosis

Related Genes :
[Clec7a Bgr Clecsf12 Dectin1] C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
[Clec6a Clec4n Clecsf10 Dectin2] C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2)
[CLEC7A BGR CLECSF12 DECTIN1 UNQ539/PRO1082] C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
[CLEC6A CLECSF10 DECTIN2] C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2)
[Olr1 Lox1] Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]
[Lrp1 A2mr] Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
[OLR1 CLEC8A LOX1] Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]
[S100a9 Cagb Mrp14] Protein S100-A9 (Calgranulin-B) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9)
[Ifitm3] Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1)
[Abca1 Abc1] ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1)
[S100a8 Caga Mrp8] Protein S100-A8 (Calgranulin-A) (Chemotactic cytokine CP-10) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (Pro-inflammatory S100 cytokine) (S100 calcium-binding protein A8)
[Ldlrap1 Arh] Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog)
[Ifitm1] Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Fragilis protein 2) (Mouse ifitm-like protein 2) (Mil-2)
[Lsr Lisch7] Lipolysis-stimulated lipoprotein receptor (Lipolysis-stimulated receptor) (Liver-specific bHLH-Zip transcription factor) (Liver-specific gene on mouse chromosome 7 protein)
[Lrp5 Lr3 Lrp7] Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
[Hivep3 KBP1 Kiaa1555 Krc Rc shn3 Zas3] Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3 homolog) (KB-binding and recognition component) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Recombinant component) (Schnurri-3) (Zinc finger protein ZAS3)
[Psmb8 Lmp7 Mc13] Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i)
[Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (MELC-CC) (Mouse brain class C) (MBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
[PSMB8 LMP7 PSMB5i RING10 Y2] Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)
[Abcg5] ATP-binding cassette sub-family G member 5 (Sterolin-1)
[LRP1 A2MR APR] Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
[Abcg1 Abc8 Wht1] ATP-binding cassette sub-family G member 1 (ATP-binding cassette transporter 8) (White protein homolog)
[Amhr2] Anti-Muellerian hormone type-2 receptor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII)
[Inpp5d 7a33 Ship Ship1] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
[CD177 NB1 PRV1 UNQ595/PRO1181] CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)
[Lrp1b Lrpdit] Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)
[PSMB10 LMP10 MECL1] Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)
[Card9] Caspase recruitment domain-containing protein 9
[Irak1bp1 Aip70 Simpl] Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1) (ActA-binding protein 70) (PLK-interacting protein) (Signaling molecule that associates with the mouse pelle-like kinase) (SIMPL)
[Syk ptk72 Sykb] Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase)

Bibliography :