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Index / Ray Biotech / Recombinant Human Vascular Endothelial Growth Factor Receptor-3 /Product Detail : 228-10490-2 Recombinant Human Vascular Endothelial Growth Factor Receptor-3
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#228-10490-2 Recombinant Human Vascular Endothelial Growth Factor Receptor-3

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  Price : 354   EUR
401   USD
274   GBP
1487   Zloty
47379   JPY
2730   NOK
2926   SEK
400   CHF

Product name : Recombinant Human Vascular Endothelial Growth Factor Receptor-3

Catalog number : 228-10490-2

Quantity: 10

Availability: Yes

Supplier name : Ray Biotech

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About this Product :

Recombinant Human Vascular Endothelial Growth Factor Receptor-3 Human samples 80 % of the research is conducted on human samples. Gentaur suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Recombinant Human Vascular Endothelial Growth Factor Receptor-3.
http://mybiofast.com/ver.php?search=human+&submit=Search

More Details about

 

Target Name

FLT4 / VEGF R3

Target Species

Human

Application Notes

Reconstitution
It is recommended to reconstitute the lyophilized FLT4 in sterile water not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Specific Activity
The activity of sVEGFR-2/Fc was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The ED50 for this effect is typically 10-30 ng/ml, corresponding to a specific activity of 33,333.33-100,000 units/mg.
Recommended Applications
Tyrosine-protein kinase receptor FLT4, PCL, FLT41, FMS-LIKE TYROSINE KINASE 4, VEGFR-3, VEGFR3.
Reconstitution
P35916

Storage/Stability

Lyophilized FLT4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FLT4 should be stored at 4°C between 2-7 days and for future use below 
-18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Format

Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
FLT4 was lyophilized from a concentrated (1 mg/ml) sterile solution containing 1x PBS.

Preparation

Soluble FLT4 Human Recombinant fused with a carboxy-terminal 6X histidine-tag produced in baculovirus is a monomeric, glycosylated, polypeptide containing the extracellular part, 25-774 amino acids and having a total molecular mass of 120 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding.The FLT4 is purified by proprietary chromatographic techniques.
Expression System
Insect Cells.

Purification

Purity:
Greater than 90.0% as determined by(a)Analysis by RP-HPLC.
(b)Analysis by SDS-PAGE.

More Information

Target Synonyms
Tyrosine-protein kinase receptor FLT4, PCL, FLT41, FMS-LIKE TYROSINE KINASE 4, VEGFR-3, VEGFR3.
Uniprot Accession Number
P35916
 
 
 
 
 

Usage

This product is furnished for LABORATORY RESEARCH USE ONLY. Not for diagnostic or therapeutic use.

 

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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1354: B Cell Receptor Signaling Pathway
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP474: Endochondral Ossification
WP100: Glutathione metabolism
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1039: Glutathione metabolism
WP104: Alanine and aspartate metabolism
WP1045: TGF-beta Receptor Signaling Pathway
WP106: Alanine and aspartate metabolism
WP1065: Endochondral Ossification
WP1067: Toll-like receptor signaling pathway

Related Genes :
[FLT1 FLT FRT VEGFR1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
[VEGFC] Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP)
[FLT4 VEGFR3] Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
[kdrl flk flk-1 flk1 flka kdr kdra vegfr2 vegfr4 vegr2 si:ch211-276g21.4] Vascular endothelial growth factor receptor kdr-like (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor-A) (Kinase insert domain receptor-like) (Protein-tyrosine kinase receptor flk-1) (Vascular endothelial growth factor receptor 4) (VEGFR-4)
[kdr flk1b kdrb si:busm1-205d10.1 si:ch211-254j6.1] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1b) (FLK-1b) (Kinase insert domain receptor) (Kinase insert domain receptor-B) (Protein-tyrosine kinase receptor flk-1b) (Vascular endothelial growth factor receptor 2 homolog B) (VEGFR-2 homolog B)
[KDR FLK1 VEGFR2] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[VEGFA VEGF] Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
[Vegfc] Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP)
[NRP1 NRP VEGF165R] Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
[VEGFD FIGF] Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF)
[NRP2 VEGF165R2] Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)
[Kdr Flk-1 Flk1] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase NYK) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[Vegfc] Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP)
[VEGFB VRF] Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF)
[EGFL7 MEGF7 UNQ187/PRO1449] Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
[Flt4 Flt-4 Vegfr3] Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
[KDR EK1 FLK-1] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Endothelial kinase receptor EK1) (Quek 1) (Quek1)
[Flt4 Flt-4 Vegfr3] Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
[Flt1 Emrk2 Flt Vegfr1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Embryonic receptor kinase 2) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)
[TNFSF15 TL1 VEGI] Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) [Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form]
[flt4 flt-4 vegfr3] Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1)
[Kdr Flk1] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[FLT4 K2 VEGFR3] Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Endothelial kinase receptor EK2) (Quek 2) (Quek2)
[Vegfa Vegf] Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
[Flt1 Flt-1 Vegfr1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)
[VEGFA VEGF] Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
[VEGFA VEGF] Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
[Vegfa Vegf] Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
[VEGFA VEGF] Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
[Vegfd Figf] Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF)

Bibliography :
[30348695] Soluble Thrombomodulin Attenuates Endothelial Cell Damage in Hepatic Sinusoidal Obstruction Syndrome.
[29722325] Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease.
[28598999] Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4.
[28298294] VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.
[26197772] Identification of high-affinity VEGFR3-binding peptides through a phage-displayed random peptide library.
[25758709] Overcoming inefficient secretion of recombinant VEGF-C in baculovirus expression vector system by simple purification of the protein from cell lysate.
[25704818] Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans.
[25428897] Generation of scFv specific to human VEGFR-3 from the neutralizing mAb BDD073.
[25342038] [Inhibitory effect of endostar on lymphangiogenesis in non-small cell lung cancer and its effect on circulating tumor cells].
[25061878] The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.