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Index / Biovis / Blocking Peptide for PARP pAb 50 ug /Product Detail : 3002BP-50 Blocking Peptide for PARP pAb 50 ug
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Blocking Peptide for PARP pAb 50 ug

 Price: 166   EUR
189   USD
129   GBP

Product name : Blocking Peptide for PARP pAb 50 ug

Catalog number : 3002BP-50

Quantity: 50 ug

Availability: Yes

Supplier name : Biovis

Data sheet Data sheet : Ask more or other datasheet now !

About this Product :

Blocking Peptide for PARP pAb 50 ug polyclonal antibodies polyclonal antobodies can be directed against a recombinant proteine, the natural protein or an epitope. The epitope generated polyclonals are virtual monoclonals. You can request the immogen of Blocking Peptide for PARP pAb 50 ug at [email protected]
http://mybiofast.com/ver.php?search=polyclonal&submit=Search

More Details about

HOST: Rabbit
IMMUNOGEN: Synthetic peptide corresponding to caspase cleavage site in human PARP (ID# BV-65-66).
FORMULATION:
100 μg (0.2 mg/ml) affinity purified rabbit anti-PARP polyclonal antibody in phosphatebuffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
SPECIES REACTIVITY: Human
STORAGE CONDITIONS:
Store at -20°C. For long term storage, aliquot and freeze at –70°C. Avoid repeated freeze/defrost cycles.
DESCRIPTION:
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP’s Nterminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
SPECIFICITY:
The polyclonal anti-PARP antibody recognizes the full length (116 kDa) and the cleaved fragment (85 kDa) of human PARP.
APPLICATION AND USAGE:
Western blot analysis (1-4 μg/ml). However, the optimal concentrations should be determined individually.

 

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