Product name : Phospho_JKK_SEK1_MKK4 pAb 100 ug
Catalog number : 3478-100
Quantity: 100 ug
Supplier name : Biovis
Data sheet : Ask more or other datasheet now !
IMMUNOGEN: Synthetic peptide surrounding Ser80 of human SEK1/MKK4.
100 μg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
SPECIES REACTIVITY: Human, Mouse, Rat
Store at -20°C. For long term storage, aliquot and freeze at –70°C. Avoid repeated freeze/defrost cycles.
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs through phosphorylation of serine and threonine residues at positions 257 and 261, respectively, by MEKK. Like MEK, SEK is a dualspecificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses the stressactivated signal transduction.
SPECIFICITY: The antibody recognizes phosphorylated SEK1/MKK4/JKK1 of human, mouse, and rat origins.
The antibody can be used in Western blotting (1-4 μg/ml). However, the optimal concentrations should be determined individually.
FOR RESEARCH USE ONLY! Not to be used on humans.
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