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Index / Biovis / Phospho_JKK_SEK1_MKK4 pAb 100 ug /Product Detail : 3478-100 Phospho_JKK_SEK1_MKK4 pAb 100 ug
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#3478-100

Phospho_JKK_SEK1_MKK4 pAb 100 ug

 Price: 360   EUR
409   USD
279   GBP

Product name : Phospho_JKK_SEK1_MKK4 pAb 100 ug

Catalog number : 3478-100

Quantity: 100 ug

Availability: Yes

Supplier name : Biovis

Data sheet Data sheet : Ask more or other datasheet now !

About this Product :

Phospho_JKK_SEK1_MKK4 pAb 100 ug polyclonal antibodies polyclonal antobodies can be directed against a recombinant proteine, the natural protein or an epitope. The epitope generated polyclonals are virtual monoclonals. You can request the immogen of Phospho_JKK_SEK1_MKK4 pAb 100 ug at [email protected]
http://mybiofast.com/ver.php?search=polyclonal&submit=Search

More Details about

HOST: Rabbit


IMMUNOGEN: Synthetic peptide surrounding Ser80 of human SEK1/MKK4.


FORMULATION:
100 μg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.


SPECIES REACTIVITY: Human, Mouse, Rat


STORAGE CONDITIONS:
Store at -20°C. For long term storage, aliquot and freeze at –70°C. Avoid repeated freeze/defrost cycles.


BACKGROUND:
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs through phosphorylation of serine and threonine residues at positions 257 and 261, respectively, by MEKK. Like MEK, SEK is a dualspecificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses the stressactivated signal transduction.


SPECIFICITY: The antibody recognizes phosphorylated SEK1/MKK4/JKK1 of human, mouse, and rat origins.


APPLICATION:
The antibody can be used in Western blotting (1-4 μg/ml). However, the optimal concentrations should be determined individually.


FOR RESEARCH USE ONLY! Not to be used on humans.

 

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