Product name : Proteinase Inhibitor 9 (PI9) pAb100 ug
Catalog number : 3544R-100
Quantity: 100 ug
Supplier name : Biovis
Data sheet : Ask more or other datasheet now !
IMMUNOGEN: Synthetic peptide mapping to the N-terminus of human PI-9 (ID# BV-431)
SPECIES REACTIVITY: human
100 μg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Store at -20oC. For long term storage, aliquot and freeze at –70oC. Avoid repeated freeze/defrost cycles.
Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killling.
The antibody recognizes 42 kDa human PI-9. Reactivity to other species has not been tested.
The antibody can be used in Western blotting (1-4 μg/ml). However, the optimal concentrations should be determined individually. Blocking peptide (Cat.# 3544R-50) is available separately.
FOR RESEARCH USE ONLY! Not to be used on humans.
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