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Index / Biovis / Betulinic acid; Appearance White to off-white solid /Product Detail : 1552-100 Betulinic acid; Appearance White to off-white solid
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#1552-100 Betulinic acid; Appearance White to off-white solid

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  Price : 419   EUR
476   USD
325   GBP
1761   Zloty
56110   JPY
3234   NOK
3465   SEK
474   CHF

Product name : Betulinic acid; Appearance White to off-white solid

Catalog number : 1552-100

Quantity: 100 mg

Availability: Yes

Supplier name : Biovis

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Alternate Name/Synonyms: 3β-Hydroxy-20(29)-lupaene-28-oic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 472-15-1

Molecular Formula: C₃₀H₄₈O₃

Molecular Weight: 456.7

Purity: ≥99%

Solubility: DMSO (1 mg/ml) or EtOH (1 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: RT

Description: Anti-tumor and anti-HIV agent. Induces apoptosis. Also displays TGR5 agonist activity (EC50 =1.04 µM)

Handling: Protect from light and moisture

 

USAGE: For Research Use Only! Not For Use in Humans.

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Pathways :
WP1008: amino acid conjugation of benzoic acid
WP1020: Fatty Acid Biosynthesis
WP105: Fatty Acid Beta Oxidation 2
WP1061: Fatty Acid Beta Oxidation
WP1075: Folic Acid Network
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1127: amino acid conjugation of benzoic acid
WP1139: Fatty Acid Biosynthesis
WP1177: Fatty Acid Beta Oxidation
WP1192: Folic Acid Network
WP1207: Fatty Acid Beta Oxidation
WP121: Colanic Acid Building Blocks Biosynthesis
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1228: Fatty Acid Biosynthesis
WP1237: Fatty Acid Beta Oxidation
WP1252: amino acid conjugation of benzoic acid
WP126: Fatty Acid Beta Oxidation 1
WP1269: Fatty Acid Beta Oxidation
WP1273: Folic Acid Network
WP1287: amino acid conjugation of benzoic acid
WP1307: Fatty Acid Beta Oxidation
WP1311: Folic Acid Network
WP133: Fatty Acid Omega Oxidation
WP1352: Fatty Acid Biosynthesis
WP137: Fatty Acid Biosynthesis, Initial Steps

Related Genes :
[SHW1 At1g69935 T17F3] Protein SHORT HYPOCOTYL IN WHITE LIGHT 1
[FASN FAS] Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]
[ABCG1 ABC8 WHT1] ATP-binding cassette sub-family G member 1 (ATP-binding cassette transporter 8) (White protein homolog)
[sgg gsk3 zw3 CG2621] Protein kinase shaggy (EC 2.7.11.1) (Protein zeste-white 3)
[WOR1 EAP2 TOS9 CAALFM_C110150WA CaO19.12348 CaO19.4884] White-opaque regulator 1
[w CG2759] Protein white
[FKS1 CND1 CWH53 ETG1 GLS1 GSC1 PBR1 YLR342W L8300.6] 1,3-beta-glucan synthase component FKS1 (EC 2.4.1.34) (1,3-beta-D-glucan-UDP glucosyltransferase) (Calcineurin dependent protein 1) (Calcofluor white hypersensitivity protein 53) (Echinocandin target gene protein 1) (FK506 sensitivity protein 1) (Glucan synthase of cerevisiae protein 1) (Papulacandin B resistance protein 1)
[Abcg1 Abc8 Wht1] ATP-binding cassette sub-family G member 1 (ATP-binding cassette transporter 8) (White protein homolog)
[SFSWAP SFRS8 SWAP] Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)
[RCN1 WBC5 LOC_Os03g17350 Os03g0281900 OsJ_10379] ABC transporter G family member 5 (ABC transporter ABCG.5) (OsABCG5) (Protein REDUCED CULM NUMBER 1) (White-brown complex homolog protein 5) (OsWBC5)
[ABCG11 COF1 DSO PEL1 WBC11 At1g17840 F2H15.7] ABC transporter G family member 11 (ABC transporter ABCG.11) (AtABCG11) (Protein CUTICULAR DEFECT AND ORGAN FUSION 1) (Protein DESPERADO) (Protein PERMEABLE LEAVES 1) (White-brown complex homolog protein 11) (AtWBC11)
[PMEL MMP115 PMEL17 SILV] Melanocyte protein PMEL (115 kDa melanosomal matrix protein) (Melanocyte protein Pmel 17) (Premelanosome protein) (Silver locus protein homolog)
[] Riboflavin-binding protein (RBP) [Cleaved into: Riboflavin-binding protein, plasma form; Riboflavin-binding protein, yolk major form; Riboflavin-binding protein, yolk minor form]
[PPP1CA PPP1A] Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
[FBP1 FBP] Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)
[ABCG12 CER5 D3 WBC12 At1g51500 F5D21.6] ABC transporter G family member 12 (ABC transporter ABCG.12) (AtABCG12) (Protein ECERIFERUM 5) (White-brown complex homolog protein 12) (AtWBC12)
[CA2] Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II)
[LPL] Lipoprotein lipase (LPL) (EC 3.1.1.34)
[ABCG4 WHITE2] ATP-binding cassette sub-family G member 4
[INS] Insulin [Cleaved into: Insulin B chain; Insulin A chain]
[ACAN AGC1] Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP)
[TGFB3] Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
[CXCL8 IL8] Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Neutrophil attractant/activation protein 1) (NAP-1) (Permeability factor 1) (PF1) (rPF1)
[PPP1CB] Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53)
[SHMT1] Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)
[INHBA] Inhibin beta A chain (Activin beta-A chain)
[H3-I; H3-II; H3-III; H3-IV; H3-V; H3-VI; H3-VII; H3-VIII] Histone H3.2 (Histone H3 class I)
[H2B-I; H2B-II; H2B-III; H2B-IV; H2B-VI] Histone H2B 1/2/3/4/6 (H2B I) (H2B II) (H2B III) (H2B IV) (H2B VI)
[rep 1a-1b] Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 (nsp1); Non-structural protein 2 (nsp2); 3C-like serine proteinase (3CLSP) (EC 3.4.21.-) (M-PRO) (nsp3) (p27); Non-structural protein 4 (nsp4); Non-structural protein 5 (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp9); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp10); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp11); Non-structural protein 12 (nsp12); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp13); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp14)]
[AOX1 AO] Aldehyde oxidase 1 (EC 1.2.3.1) (Azaheterocycle hydroxylase 1) (EC 1.17.3.-) (Retinal oxidase) (Retinoic acid synthase)

Bibliography :
[30899171] A novel triterpenoid 16-hydroxy betulinic acid isolated from attributes multi-faced pharmacological activities.
[30870993] Antiproliferative Activity of (-)-Rabdosiin Isolated from L.
[30850585] Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog.
[30847340] Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity.
[30813082] Gemcitabine and betulinic acid co-encapsulated PLGA-PEG polymer nanoparticles for improved efficacy of cancer chemotherapy.
[30810367] A new pentacyclic triterpenoid from the leaves of Rhododendron dauricum L. with inhibition of NO production in LPS-induced RAW 264.7 cells.
[30799179] Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK.
[30776566] Phytochemical profile of Syzygium formosum (Wall.) Masam leaves using HPLC-PDA-MS/MS and a simple HPLC-ELSD method for quality control.
[30772482] Inhibitory ASIC2-mediated calcineurin/NFAT against colorectal cancer by triterpenoids extracted from Rhus chinensis Mill.
[30754716] Triterpene Derivatives as Relevant Scaffold for New Antibiofilm Drugs.