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Index / BPS Bioscience / Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel /Product Detail : 60409 Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel
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#60409 Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel

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  Price : 639   EUR
726   USD
496   GBP
2687   Zloty
85597   JPY
4933   NOK
5286   SEK
723   CHF

Product name : Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel

Catalog number : 60409

Quantity: 500 reactions

Availability: Yes

Supplier name : BPS Bioscience

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More Details about

Product Description
The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the
hedgehog signaling pathway. The hedgehog pathway controls stem cell growth in
embryonic and adult tissues and promotes tumor growth in a number of human cancers.
The mammalian hedgehog proteins, Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and
Desert Hedgehog (Dhh) activate hedgehog signaling by binding to their membrane
receptor “Patched” (PTCH). This binding releases PTCH inhibition of Smoothened (Smo)
and allows Smo to activate the Gli family of transcription factors, leading to transcription
and expression of hedgehog signal target genes.

The Gli Reporter – NIH3T3 Cell Line contains the firefly luciferase gene under the
control of Gli responsive elements stably integrated into NIH3T3 cells. Luciferase
expression correlates with activation of the hedgehog signaling pathway. This cell line is
validated for its response to stimulation with murine Sonic Hedgehog and to treatment
with inhibitors of the hedgehog signaling pathway.

Applications
• Monitor Hedgehog signaling pathway activity.
• Screen activators or inhibitors of the Hedgehog signaling pathway.

Format
Each vial contains ~1.5 X 10^6 cells in 1 ml of 10% DMSO.

Storage
Immediately upon receipt, store in liquid nitrogen.

References
1. Kinzler KW et al. (1990) The GLI gene encodes a nuclear protein which binds
    specific sequences in the human genome. Mol Cell Biol. 10(2):634-642.
2. Mullor JL et al. (2002) Pathways and consequences: Hedgehog signaling in
    human disease. Trends Cell Biol. 12(12):562-569.
3. Peukert S et al. (2010) Small-molecule inhibitors of the hedgehog signaling
    pathway as cancer therapeutics. ChemMedChem. 5(4):500-512.

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BPS_Bioscience \ Gli_Reporter_–_NIH3T3_Cell_line_(Hedgehog_Pathway),The_Gli_Reporter_–_NIH3T3_Cell_Line_is_designed_for_monitoring_the_activity_of_the_hedgehog_signaling_pathway._The_hedgehog_pathway_controls_stem_cel \ 60409
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Related products : Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel


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Pathways :
WP1011: T Cell Receptor Signaling Pathway
WP1022: Hedgehog Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1141: Hedgehog Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP116: Hedgehog Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1353: Hedgehog Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP23: B Cell Receptor Signaling Pathway
WP2328: Allograft rejection
WP274: B Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP352: T Cell Receptor Signaling Pathway
WP47: Hedgehog Signaling Pathway
WP480: T Cell Receptor Signaling Pathway
WP492: Hedgehog Signaling Pathway
WP574: Hedgehog Signaling Pathway
WP780: T Cell Receptor Signaling Pathway
WP790: Hedgehog Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP905: Hedgehog Signaling Pathway
WP908: B Cell Receptor Signaling Pathway

Related Genes :
[Hras Hras1] GTPase HRas (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
[Shh Hhg1] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein 19 kDa product)]
[hh CG4637] Protein hedgehog [Cleaved into: Protein hedgehog N-product (Hh-Np) (N-Hh); Protein hedgehog C-product (Hh-Cp) (C-Hh)]
[GLI3] Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]
[Prkce Pkce Pkcea] Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)
[SHH] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[shha shh vhh1] Sonic hedgehog protein A (SHHA) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) (VHH-1) [Cleaved into: Sonic hedgehog protein A N-product (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein N-product) (ShhN)]
[Gli3] Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]
[Shh Vhh-1] Sonic hedgehog protein (SHH) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[Ptprj Byp Scc1] Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (Susceptibility to colon cancer 1) (CD antigen CD148)
[SHH] Sonic hedgehog protein (SHH) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[GLI1 GLI] Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)
[IL6 IFNB2] Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
[GLI2 THP] Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein)
[Arntl Bmal1] Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arnt3) (Brain and muscle ARNT-like 1)
[KDR FLK1 VEGFR2] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[IHH] Indian hedgehog protein (IHH) (HHG-2) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]
[Ihh] Indian hedgehog protein (IHH) (HHG-2) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]
[shh] Sonic hedgehog protein (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) (VHH-1) (X-SHH) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[hh GI24573] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GE23980] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GG12458] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GF18029] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GM23589] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GJ22641] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GL23598] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GH23852] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GK12833] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[Gli1 Gli] Zinc finger protein GLI1 (Glioma-associated oncogene homolog)
[Gli2 Thp] Zinc finger protein GLI2 (Tax helper protein)

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