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Index / BPS Bioscience / Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel /Product Detail : 60409 Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel
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Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel

 Price: 639   EUR
726   USD
496   GBP

Product name : Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel

Catalog number : 60409

Quantity: 500 reactions

Availability: Yes

Supplier name : BPS Bioscience

Data sheet Data sheet : Ask more or other datasheet now !

More Details about

Product Description
The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the
hedgehog signaling pathway. The hedgehog pathway controls stem cell growth in
embryonic and adult tissues and promotes tumor growth in a number of human cancers.
The mammalian hedgehog proteins, Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and
Desert Hedgehog (Dhh) activate hedgehog signaling by binding to their membrane
receptor “Patched” (PTCH). This binding releases PTCH inhibition of Smoothened (Smo)
and allows Smo to activate the Gli family of transcription factors, leading to transcription
and expression of hedgehog signal target genes.

The Gli Reporter – NIH3T3 Cell Line contains the firefly luciferase gene under the
control of Gli responsive elements stably integrated into NIH3T3 cells. Luciferase
expression correlates with activation of the hedgehog signaling pathway. This cell line is
validated for its response to stimulation with murine Sonic Hedgehog and to treatment
with inhibitors of the hedgehog signaling pathway.

Applications
• Monitor Hedgehog signaling pathway activity.
• Screen activators or inhibitors of the Hedgehog signaling pathway.

Format
Each vial contains ~1.5 X 10^6 cells in 1 ml of 10% DMSO.

Storage
Immediately upon receipt, store in liquid nitrogen.

References
1. Kinzler KW et al. (1990) The GLI gene encodes a nuclear protein which binds
    specific sequences in the human genome. Mol Cell Biol. 10(2):634-642.
2. Mullor JL et al. (2002) Pathways and consequences: Hedgehog signaling in
    human disease. Trends Cell Biol. 12(12):562-569.
3. Peukert S et al. (2010) Small-molecule inhibitors of the hedgehog signaling
    pathway as cancer therapeutics. ChemMedChem. 5(4):500-512.

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