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Anti-Human , Rabbit Polyclonal Antibody ; Adipocyte FABP
/Product Detail : RD181037050 Anti-Human , Rabbit Polyclonal Antibody ; Adipocyte FABP
Product name : Anti-Human , Rabbit Polyclonal Antibody ; Adipocyte FABP
Catalog number : RD181037050
Quantity: 0.05 mg
Supplier name : Biovend
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Anti-Human , Rabbit Polyclonal Antibody ; Adipocyte FABP Human samples 80 % of the research is conducted on human samples. Gentaur suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and elisa kit to Human proteins as well as Anti-Human , Rabbit Polyclonal Antibody ; Adipocyte FABP.
Adipocyte fatty acid binding protein (AFABP) is a 15 kDa member of the intracellular fatty acid binding protein (FABP) family, which is known for the ability to bind fatty acids and related compounds in an internal cavity. AFABP is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells . In mice, targeted mutations in AFABP provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from AFABP-deficient mice also have reduced efficiency of lipolysis in vitro and in vivo. Such mice exhibite moderately improved systemic dyslipidemia. AFABP expression occur in macrophages upon differentiation and activation. In such cells, AFABP modulates inflammatory responses and cholesterol ester accumulation. Total or macrophage-specific AFABP deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. AFABP has a central role in the development of major components of the metabolic syndrome due to its distinct actions in adipocytes and macrophages.
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