Product name : Human, Adipocyte FABP , Rec. Prot.
Catalog number : RD172036100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Adipocyte fatty acid binding protein AFABP is a 15 kDa member of the intracellular fatty acid binding protein (FABP) family. It is known for its ability to bind fatty acids and related compounds like bile acids or retinoids in an internal cavity. AFABP is expressed in a differentiation-dependent fashion in adipocytes. It is also a critical gene in the regulation of the biological function of these cells . In mice, targeted mutations in AFABP provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from AFABP-deficient mice have also reduced efficiency of lipolysis in vitro and in vivo. Such mice exhibited moderately improved systemic dyslipidemia. According to recent studies, AFABP is expressed in macrophages upon differentiation and activation. In these cells, AFABP modulates inflammatory responses and cholesterol ester accumulation. In addition, total or macrophage-specific AFABP deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for AFABP in the development of major components of the metabolic syndrome through its distinct actions in adipocytes and macrophages.
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