Product name : Virus, Hepatitis B Protein X , Rec. Prot.
Catalog number : RD972038100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Hepatitis B virus X protein (HBx) is a 17 kD transcriptional coactivator that plays a major role in the regulation of genes related to inflammation and cell survival. It regulates many transcription factors including nuclear factor kappa B (NF-kappaB). It also plays a key role in hepatocarcinogenesis. HBx facilitates the binding of cAMP response element binding protein (CREB) to its responsive element. HBx stabilizes the cellular coactivator ASC-2 through direct protein-protein interaction, affecting the regulation of genes, which are actively transcribed in liver cancer cells.
Moreover, HBx transactivates both JNK and MAPK signal transduction pathways in association with the mobilization of cytosolic Ca2+. In addition, HBx decreases the expression of PTEN a known tumor suppressor and a negative regulator of phosphatidylinositol 3'-kinase/AKT. HBx also decreased the expression of PTEN in HBx-transfected cells.
The etiology of hepatocellular carcinoma (HCC) is involved with hepatitis B virus (HBV) infection and HBx in particular plays a role in the development of HBV-related HCC. The persistence of HBx is important to the pathogenesis of early HCC. HBx expression in the liver during chronic HBV infection may be an important prognostic marker for the development of HCC.
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