Product name : Human, Herstatin , Rec. Prot.
Catalog number : RD172039100
Quantity: 0.1 mg
Supplier name : Biovend
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HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer. It displays potent oncogenic activity when overexpressed. Herstatin is the product of the alternative HER-2 transcript and it retains intron 8.
The herstatin mRNA can be found in the human kidney and liver, but its level is lower compared to that of p185HER-2 mRNA in carcinoma cells, which contains an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
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