Product name : Human, Osteoblast Specific Factor 1 , Rec. Prot.
Catalog number : RD172044100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Pleiotrophin contains 136 amino acid residues. The sequence is very rich in cationic amino acids (24% of the residues). Lysine cluster sequences are found in the N-terminal and C-terminal ends of the structure.
The OSF-1 gene is expressed in mouse calvarial osteoblast-enriched cells and in mouse brain tissues, but not in thymus, spleen, kidney, liver, lung, testis or heart.
Pliotrophin has the ability to promote adhesion, migration, expansion, and differentiation of human osteoprogenitor cells. The embryonic growth and differentiation factor pleiotrophin is found also in adults with inflammatory diseases. In osteoarthritis, pleiotrophin is especially expressed in early stages and its concentrations in the synovial fluid could serve as a marker for the progress of the disease. Pleitrophin might be involved in the early-stage cartilage repair in osteoarthritis.
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