Product name : Human, Osteostat , Rec. Prot.
Catalog number : RD172111100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Osteostat is the cytokine that binds with TNFRSF18/AITR/GITR. It is important for interactions between activated T-lymphocytes and endothelial cells. It may modulate T-lymphocyte survival in peripheral tissues. Osteostat is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells after stimulation by lipopolysaccharides.
Osteostat protein is present in human microvascular EC and is highly regulated by IFN-alpha and IFN-beta. Osteostat inhibits differentiation of osteoclasts from monocytic precursor cells. It suppresses the early stage of osteoclastogenesis via inhibition of macrophage factor-induced activator of NF-kappaB (RANK) expression in the osteoclast precursor cells. Osteostat does not inhibit lipopolysaccharide-induced RANK expression in monocytes and dendritic cells, or activation-induced RANK expression in T cells. Osteostat is a novel regulator of osteoclast generation and substantiates the endothelium in bone physiology.
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