Product name : Human, S100-A11, E.coli , Rec. Prot.
Catalog number : RD172220100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
S100A11 (S100C; calgizzarin) was first isolated from chicken gizzard smooth muscle. A human homologue was later identified in human colorectal cancer cells and in colorectal normal mucosa, with much higher expression than in the cancer cells. S100A11 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. The polypeptide chain contains 105 amino acid residues giving molecular weight of unmodified monomeric protein 11.74 kDa. Disulphide bridge linking two monomers in the dimer via Cys-11 residues was found in its structure. The protein can be phosphorylated on some residues from which at least phosphorylation on Thr-10 causes significant structural changes. S100A11 binds to annexins A1 and A2, the DNA-dependent ATPase Rad54B, p53 and RAGE. It was proposed that up-regulated chondrocyte expression of S100A11 (as RAGE ligand) in OA cartilage and RAGE signaling through the p38 MAPK pathway promote inflammation-associated chondrocyte hypertrophy. RAGE signaling mediated by S100A11 thereby might have the potential to contribute to the progression of OA. S100A11 is also secreted and exerts RAGE dependent signaling in human keratinocytes. S100A11 is present in many different human both normal and cancer tissues. S100A11 appears to have distinct features depending on the tumour involved. In bladder carcinoma or renal carcinoma this expression is related to tumour suppression. However S100A11 is a tumour promoter in prostate cancer, breast and pancreatic cancer. S100A11 is also one of the potential biomarkers of infective endocarditis.
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