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Index / Biovend / Human, S100P, E.coli , Rec. Prot. /Product Detail : RD172048100 Human, S100P, E.coli , Rec. Prot.
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  Price : 429   EUR
486   USD
332   GBP
1802   Zloty
57399   JPY
3308   NOK
3544   SEK
485   CHF

Product name : Human, S100P, E.coli , Rec. Prot.

Catalog number : RD172048100

Quantity: 0.1 mg

Availability: Yes

Supplier name : Biovend

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The S100P has been brain S100 protein originally described as placental protein of about 95 amino acid residues and shares 50% sequence identity α and β.

 

S100 protein is believed that in the mediation of the intracellular Ca (2), which by binding EF-hand superfamily of calcium (2) binding proteins are involved in modulating (2)-dependent target proteins in a Ca which is a dimer of members is small amount.

 

It is a dysregulation, DU145, PC3 S100P, androgen-independent prostate cancer cell line LNCaP-R cells it is possible to play a role in the pathogenesis of prostate cancer.

 

In ductal hyperplasia, rather than infiltrating ductal carcinoma in situ in normal tissues and overexpression of S100P is an important role in imortalization of human mammary epithelial cells progress of tumors in vitro and in vivo play It is early events that may.

 

In NIH3T3 cells from the culture medium substrate which is performed in the presence of S100P in the culture medium 5, or exposure to chemotherapeutic agents expression S100P - fluorouracil after stripping to increase the survival rate and cell proliferation was enhanced. Purification of addition of S100P the wild type NIH3T3 cells survival effect proliferation and S100P expression to the activation of NF-B and Erks determine the mechanisms dependent in a concentration manner and time be replicated in these involved the effect of the (receptor activity of advanced glycation end products) S100P RAGE activation was correlated, we tested the hypothesis, dass It was found that co-immunoprecipitate S100P with RAGE. In addition, the effect of S100P with RAGE is disturbing, including the administration of the peptide of Amphoterin in that antagonize the activation of RAGE, as is known by the expression of dominant negative RAGE and anti-RAGE antibodies for the survival of cell signaling, proliferation, and was blocked by the drug. These data suggest that there act in an autocrine manner on RAGE that S100P to stimulate cell proliferation and survival.

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Pathways :
WP1772: Apoptosis Modulation and Signaling
WP2107: pathways in human cancer
WP2272: Pathogenic Escherichia coli infection
WP2361: Gastric cancer network 1

Related Genes :
[S100PBP S100PBPR] S100P-binding protein (S100P-binding protein Riken)
[EZR VIL2] Ezrin (Cytovillin) (Villin-2) (p81)
[S100A1 S100A] Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
[S100B] Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
[IL11] Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin)
[TFIP11 STIP HSPC006] Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1)
[TERF2IP DRIP5 RAP1 PP8000] Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)
[CACYBP S100A6BP SIP PNAS-107] Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein)
[AGER RAGE] Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
[Cacybp Sip] Calcyclin-binding protein (CacyBP) (Siah-interacting protein)
[Cacybp] Calcyclin-binding protein (CacyBP)
[PPP5C PPP5] Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
[Ezr Vil2] Ezrin (Cytovillin) (Villin-2) (p81)
[Ezr Vil2] Ezrin (Cytovillin) (Villin-2) (p81)
[EZR VIL2] Ezrin (Cytovillin) (Villin-2) (p81)
[ERVK-6 ERVK6] Endogenous retrovirus group K member 6 Rec protein (Central open reading frame) (c-orf) (cORF) (Endogenous retrovirus K protein 6) (HERV-K(C7) Rec protein) (HERV-K(HML-2.HOM) Rec protein) (HERV-K108 Rec protein) (HERV-K_7p22.1 provirus Rec protein) (K-Rev) (Rev-like protein) (Rev/Rex homolog)
[APC2 APCL] Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like)
[S100a1] Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[SIPA1L1 E6TP1 KIAA0440] Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)
[APC DP2.5] Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
[TRIP13 PCH2] Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13)
[OR1D2 OLFR1] Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)
[S100A1] Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
[CCNB1IP1 C14orf18 HEI10] E3 ubiquitin-protein ligase CCNB1IP1 (EC 2.3.2.27) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10) (RING-type E3 ubiquitin transferase CCNB1IP1)
[Apc2 APC APC2 apc2 D-APC2 d-APC2 dAPC2 dApc2 dapc2 Dm APC2 Dmel\CG6193 E-APC e-apc E-APC dAPC2 CG6193 Dmel_CG6193] Adenomatous polyposis coli 2 (Adenomatous polyposis coli 2, isoform A) (Adenomatous polyposis coli 2, isoform C) (Epithelial adenomatous polyposis coli)
[MAEA EMP HLC10 PIG5] E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)
[S100a1] Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
[APEX1 APE APE1 APEX APX HAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[Ppp5c] Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PPT)

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