Product name : Human, Thyrostimulin alpha subunit , Rec. Prot.
Catalog number : RD172110100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Human thyrostimulin ranks among the glycoprotein hormone family. These hormones consist of two subunits, the common alpha- and specific beta-subunits, which associate noncovalently to form a heterodimer. The alpha-subunit combines with four distinct beta-subunits giving rise to four biologically active hormones in humans: FSH, LH, TSH, and CG. FSH, LH, and TSH. These are mainly expressed in the anterior pituitary and are essential for the coordinated endocrine regulation in the hypothalamus. This on the other hand can activate a specific G protein–coupled receptors in the thyroid (TSH receptor) and gonads (LH and FSH receptors), respectively.
The heterodimeric glycoprotein hormones have been found only in vertebrates. They are highly conserved in a variety of organisms from primitive rayfin fish (Chondrostei) to humans in terms of both primary sequences and functional characteristics. Corticotroph-derived glycoprotein hormone (CGH), is a noncovalent heterodimer of glycoprotein hormone alpha 2 (GPHA2) and glycoprotein hormone beta 5 (GPHB5). Recombinant A2/B5 heterodimeric glycoproteins activates human TSH receptors, but not LH and FSH receptors, and shows high affinity to TSH receptors in a radioligand receptor assay. The heterodimer also stimulates cAMP production and thymidine incorporation by cultured thyroid cells and increases serum thyroxine levels in TSH-suppressed rats in vivo. The expression of thyrostimulin in the anterior pituitary known to express TSH receptors suggests a paracrine mechanism.
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