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Human, Trefoil factor 2 (Spasmolytic polypeptide, Spasmolysin, SP, TFF2) , Rec. Prot.
/Product Detail : RD172159100 Human, Trefoil factor 2 (Spasmolytic polypeptide, Spasmolysin, SP, TFF2) , Rec. Prot.
Product name : Human, Trefoil factor 2 (Spasmolytic polypeptide, Spasmolysin, SP, TFF2) , Rec. Prot.
Catalog number : RD172159100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Trefoil factor 2 (TFF2 )is a small secreted protein with a molecular weight of 12 kDa. It belongs to the TFF protein family that is characterized by a clover leaf just like the disulphide structure named the TFF domain. TFF2 contains two trefoil domains and has a very compact structure, which may be responsible for its extremely high resistance against the harsh environment in the gastrointestinal tract. The most abundant expression of TFFs is found in GI tract (especially in stomach, colon and pancreas), where they are co-localised with mucins. TFF2 is usually co-localised with MUC6 and probably mediates mucin cross-linking and stabilization of the mucin layer as do the other members of the TFF family. A study examining people with Crohn´s disease and inflammatory bowel disease showed that TFF2 level in serum is increased during the inflammatory state. Another study found that TFF2 levels are high in septic patients and that the level correlates with prognosis of the septic state. High expression of TFF2 was also found in skeletal muscle, liver, heart, spleen, thymus, lymph nodes and bone marrow. The exact function of TFF2 has not yet been revealed, but there is an evidence that it is connected with modulation of immune response (TFF2 deficient mice revealed significant change in expression of several genes involved in MHC class I antigen presentation), allergy and asthma (upregulation of TFF2 by diverse antigens). High levels of TFF2 in serum were also found in patients with prostate and other types of cancer (breast, colon and ovarian tumors) but its prognostic value has not yet been proved.
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