Product name : Human, Vaspin , Rec. Prot.
Catalog number : RD172097100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Visceral adipose tissue is an adipocytokine, which is part of a member of the serine protease family. The inhibitory activity of vaspin has not been described up to now, but its reactive site loop is typical for this proteinase family. Human Vaspin protein is composed of 395 amino acids and has a molecular weight of approximately 45.2 kDa and predicted pI 9.26. The cDNA was first isolated from white adipose tissue of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Vaspin mRNA expression is specific for visceral adipose tissues and it is also found circulating in the serum. The level of serum vaspin OLETF in rats increases with age up to the peak of obesity, body weight and insulin resistance. On the other hand, it decreases with worsening of diabetes. Vaspin expression is missing in the diabetes-resistant lean rats, the subdermal brown fatty tissue and other non-adipose tissues in OLEFT rats. These findings lead to the conclusion that the target tissue for insulin sensitising effect of vaspin is white adipose tissue. In humans, elevated serum concentration of vaspin is associated with obesity and impaired insulin sensitivity. A correlation between increased vaspin levels, BMI and decreased insulin sensitivity has not been yet observed in patients with type 2 diabetes the. Vaspin expression decreased when diabetes worsened and its levels normalised when insulin or pioglitazone is applied. Gender differences in vaspin serum levels have been found in separate studies by two different authors. The low levels of vaspin in serum seem to be typical for lean test subjects and athletes with long-term physical training. On the other hand, serum vaspin concentration increases in overweight people after they lose weight due to the increase in exercise. This paradox has been explained by the fact that serum vaspin level is differentially regulated in the non-active resting state and after exercise.
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