Product name : Human, Visinin-Like Protein 1 , Rec. Prot.
Catalog number : RD172119100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Visinin is a cytoplasmic protein with a molecular weight of 22 kDa, consisting of 191 amino acid residues. It belongs to the visinin/recoverin subfamily of neuronal calcium sensor proteins involved in the mechanisms for calcium-dependent signal transduction in neurons. It is present mainly in the brain, the nerve cells and to some extent in the liver, lung, kidney, spleen, pancreas and colon. When it is localized at the membrane, it modulates various cellular signal transduction pathways. Such pathways comprise cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), signaling in neural cells, human embryonic kidney cells, the pancreatic β cell line MIN6, and various skin tumor cell lines. It contains four internal repeats of 36–38 amino-acids, each containing a potential EF-hand domain. Two of the four EF-hand Ca2+-binding motifs of VILIP-1 can bind to Ca2+ or Mg2+in a non-cooperative manner. Binding of Ca2+ leads to specific conformational changes in the protein and this may regulate the interaction of VILIP with intracellular target molecules. VILIP-1 has been identified as a potential biomarker for brain injury and several neurodegenerative diseases. VILIP-1-expressing cells appear to be vulnerable to neurotoxic insults. As a result, the protein is released into the cerebrospinal fluid (CSF), and can be used as a biomarker for stroke and Alzheimer’s disease. The intracellular protein was detected in cerebrospinal fluid (CSF) of a rat model of stroke and in plasma of patients after stroke. According to samples taken 24 hours after the onset of a stroke, VILIP-1 was detected in 44% of subjects with stroke and in 8% of controls with no stroke. In Alzheimer’s disease, CSF levels of VILIP-1 were significantly higher than in healthy individuals. Post mortem studies in the hippocampus of schizophrenia patients revealed great quantities of VILIP-1 in interneurons, but low quantities in pyramidal neurons. VILIP-1 has also been found in different types of cancer and in pancreatic α- and β-cells, as it is involved in the regulation of insulin secretion and insulin gene expression.
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