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Index / Abfron / anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse /Product Detail : LF-MA0121 anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse
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anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse

 Price: 432   EUR
490   USD
335   GBP

Product name : anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse

Catalog number : LF-MA0121

Quantity: 100 ul

Availability: Yes

Supplier name : Abfron

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About this Product :

anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse mus musculus murine anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse detects proteins from variouse species most likely human.
http://mybiofast.com/ver.php?search=musculus&submit=Search

anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse imuno globulin 2 22% abundance in serum with lof affinityfor anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse
http://antibody-antibodies.com/anti-elisa/IgG2.html

anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse http://biotech-map.com/aa_search/table_sample.html?q=monoclonal&filter=
Description
anti-Superoxide Dismutase 3 (1H12), Mouse monoclonal to Superoxide Dismutase 3, Isotype IgG2b, Host Mouse is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against. If used correctly and according the protocol, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications. Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches; in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required.

More Details about

 

Product Name anti-Superoxide Dismutase 3 (1H12)
Pack Size 100 ul
Description Mouse monoclonal to Superoxide Dismutase 3
Immunogen Recombinant human protein purified from E.coli
Clonality Monoclonal Antibody
Host Mouse
Clone# 1H12
Isotype IgG2b, k
Cross ReactivityHELP Hu
ApplicationHELP
WB (1:2000)
IP (1ul)
IHC-P
Research Area ROS Signaling
Background Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3) (1). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit (2). The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain (3). SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways (4). SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
Function Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Cellular Location Secreted
Database Link

 

SwissProt : P08294

OMIM : 185490

GeneId : 6649

GeneCard : GC04P024472

 

Reference 1) Kuninaka, S. et al. (2000) Br. J. Cancer. 83:928-934. 
2) Strange, R.W. et al. (2003) J. Mol. Biol. 328: 877-891. 
3) Weisiger, R. A., and Fridovich, I. (1973) J. Biol. chem. 248: 3582-3592. 
4) Enghild, J. J. et al. (1999) Biochem J. 317:51-57.
Positive Control Bosc23 cell transfected with Myc-His-SOD3
Composition HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and glycerol
Storage Store for 1 year at -20°C from date of shipment
Purification Ammonium sulfate precipitation

 

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