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Index / Biovis / Hh Signaling Pathway Antagonist /Product Detail : 1659-1 Hh Signaling Pathway Antagonist
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#1659-1 Hh Signaling Pathway Antagonist

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  Price : 178   EUR
202   USD
138   GBP
750   Zloty
23904   JPY
1377   NOK
1476   SEK
202   CHF

Product name : Hh Signaling Pathway Antagonist

Catalog number : 1659-1

Quantity: 1 mg

Availability: Yes

Supplier name : Biovis

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More Details about

Alternate Name/Synonyms: N-[4-Chloro-3-(trifluoromethyl)phenyl]-N’-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl-urea

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 330796-24-2

Molecular Formula: C₂₃H₁₅ClF₄N₄O₂

Molecular Weight: 490.84

Purity: ≥97% by HPLC

Solubility: DMSO

Storage Temp.: +4°C

Shipping Conditions: RT

Description: Cell-permeable. A potent antagonist of the Hedgehog (Hh) signaling pathway (IC₅₀ = 70 nM).

Handling: Protect from air and light

 

USAGE: For Research Use Only! Not For Use in Humans.

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Pathways :
WP10: IL-9 Signaling Pathway
WP1004: Kit Receptor Signaling Pathway
WP1010: Wnt Signaling Pathway and Pluripotency
WP1011: T Cell Receptor Signaling Pathway
WP1012: IL-7 Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1016: Wnt Signaling Pathway
WP1022: Hedgehog Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1029: Notch Signaling Pathway
WP1031: IL-3 Signaling Pathway
WP1037: p38 MAPK Signaling Pathway
WP1044: ErbB signaling pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP1052: Id Signaling Pathway
WP1055: IL-4 signaling Pathway
WP1063: G13 Signaling Pathway
WP1064: Delta-Notch Signaling Pathway
WP1067: Toll-like receptor signaling pathway
WP1087: IL-5 Signaling Pathway
WP1091: IL-2 Signaling Pathway
WP1092: IL-9 Signaling Pathway
WP1094: IL-6 Signaling Pathway

Related Genes :
[hh CG4637] Protein hedgehog [Cleaved into: Protein hedgehog N-product (Hh-Np) (N-Hh); Protein hedgehog C-product (Hh-Cp) (C-Hh)]
[SHH] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[IL36RN FIL1D IL1F5 IL1HY1 IL1L1 IL1RP3 UNQ1896/PRO4342] Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)
[Shh Hhg1] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein 19 kDa product)]
[shha shh vhh1] Sonic hedgehog protein A (SHHA) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) (VHH-1) [Cleaved into: Sonic hedgehog protein A N-product (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein N-product) (ShhN)]
[HRH1] Histamine H1 receptor (H1R) (HH1R)
[IL1RN IL1F3 IL1RA] Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra)
[Ecsit Sitpec] Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)
[dkk1b DKK1 dkk1] Dickkopf WNT-signaling pathway inhibitor 1b (Dickkopf-like protein 1) (Dickkopf1)
[SHH] Sonic hedgehog protein (SHH) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[WISP1 CCN4] WNT1-inducible-signaling pathway protein 1 (WISP-1) (CCN family member 4) (Wnt-1-induced secreted protein)
[Shh Vhh-1] Sonic hedgehog protein (SHH) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[ECSIT] Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)
[hh GI24573] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GE23980] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GG12458] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GF18029] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GM23589] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GJ22641] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GL23598] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GH23852] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[hh GK12833] Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
[Hrh3] Histamine H3 receptor (H3R) (HH3R)
[IL36RN Fil1d Il1f5 Il1h3 Il1hy1] Interleukin-36 receptor antagonist protein (IL-36Ra) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 homolog 3) (IL-1H3) (Interleukin-1-like protein 1) (IL-1L1)
[Il1rn Il-1ra] Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (IL1 inhibitor)
[WISP3 CCN6 UNQ462/PRO790/PRO956] WNT1-inducible-signaling pathway protein 3 (WISP-3) (CCN family member 6)
[DACT1 DPR1 HNG3] Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein)
[Grem1 Cktsf1b1 Drm] Gremlin-1 (Cysteine knot superfamily 1, BMP antagonist 1) (Down-regulated in Mos-transformed cells protein)
[dkk1b] Dickkopf WNT-signaling pathway inhibitor 1b
[BAD BBC6 BCL2L8] Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)

Bibliography :
[30557039] Overcoming the emerging drug resistance of smoothened: an overview of small-molecule SMO antagonists with antiresistance activity.
[30447254] RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism.
[30069764] Vismodegib.
[29945863] SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis.
[29857275] Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.
[29587133] The role of Hedgehog signaling in cementoblast differentiation.
[29437795] Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.
[29348431] A synthetic combinatorial approach to disabling deviant Hedgehog signaling.
[29237157] Hypoxia Accelerates Aggressiveness of Hepatocellular Carcinoma Cells Involving Oxidative Stress, Epithelial-Mesenchymal Transition and Non-Canonical Hedgehog Signaling.
[29166577] Cell cycle-related kinase regulates mammalian eye development through positive and negative regulation of the Hedgehog pathway.