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Adiponectin (HEK293 antigen) Rabbit Polyclonal Antibody
/Product Detail : RD581023100 Adiponectin (HEK293 antigen) Rabbit Polyclonal Antibody
Product name : Adiponectin (HEK293 antigen) Rabbit Polyclonal Antibody
Catalog number : RD581023100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Adiponectin (HEK293 antigen) Rabbit Polyclonal Antibody rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. Do not freeze taw, rather use Adiponectin (HEK293 antigen) Rabbit Polyclonal Antibody from the fridge if your use is less than 1 or 2 weeks.
Adiponectin, also known as Acrp30, AdipoQ and GBP-28, is a 244 aminoacid protein. It is the product of the apM1 gene, which is physiologically active and chiefly expressed in adipose cells. The protein belongs to the soluble defense collagen superfamily. It has a collagen-like domain structurally homologous with collagen VIII and X. It has a C1q-like complement factor globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found in the serum. Together these complexes make up approximately 0.01% of the total serum protein. AdipoR1, an adiponectin receptor, is abundantly expressed in skeletal muscle, whereas another of its receptors,AdipoR2, is predominantly expressed in the liver. Paradoxically, adipose tissue-expressed adiponectin levels are inversely proportioanl to the degree of adiposity. Adiponectin concentrations is unproportional to glucose, insulin, triglyceride concentrations, liver fat content and body mass index. However it is proportional to high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. A notable feature of adiponectin is that low levels of its serum predict type 2 diabetes independently of other risk factors. Adiponectin also inhibits the inflammatory processes of atherosclerosis suppressing adhesion and cytokine molecules in vascular endothelial cells and macrophages, respectively. This adipokine acts as a backbone of newly formed collagen in myocardial remodelling after ischaemic injury. Furthermore, it stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signalling in endothelial cells. Low serum adiponectin levels are found in patients with coronary artery disease. Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. In general, adiponectin has the potential to become a clinically relevant parameter to be measured routinely in individuals at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome.
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