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Index / Biovend / Herstatin Rec. Prot. /Product Detail : RD172039100 Herstatin Rec. Prot.
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Herstatin Rec. Prot.

 Price: 460   EUR
522   USD
356   GBP

Product name : Herstatin Rec. Prot.

Catalog number : RD172039100

Quantity: 0.1 mg

Availability: Yes

Supplier name : Biovend

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HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer. It displays potent oncogenic activity when overexpressed. Herstatin is the product of the alternative HER-2 transcript and it retains intron 8.

The herstatin mRNA can be found in the human kidney and liver, but its level is lower compared to that of p185HER-2 mRNA in carcinoma cells, which contains an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.

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