Product name : Nesfatin-1, E. coli Rec. Prot.
Catalog number : RD172227100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Nesfatin-1 is a polypeptide consisting of 82 amino acids with high level of homology in human, mouse and rat. Nesfatin-1 has been localized in the brain, particulary in the nuclei of the hypothalamus, in the adipose tissue, the gastrointestinal tract and in serum and cerebrospinal fluid. Nesfatin-1 is a satiety molecule affecting fat metabolism. Intracerebroventricular administration of nesfatin-1 decreases in food intake and body weight and increases in sympathetic nerve activity and mean arterial pressure. One product of of Nesfatin-1 is leptin – independent, it is probably mediated by melanocortin system. Nesfatin-1 can be user to treat obesity, even in individuals with leptin resistence. Due to its presence in serum Nesfatin-1 could also serve as a clinical marker in the diagnosis of many diseases. The important role of nesfatin-1 in metabolism of glucose and insulin has been reported in several studies. Different concentrations were observed in patients with diabetes mellitus type I. and II. In individuals with DM type II. postprandial concentration of nesfatin-1 was significantly lower than that of DM type I. and healthy subjects. Different levels of Nesfatin-1 was measured in patients with anorexia nervosa and panic disorders in comparison with a control healthy group. Data obtained in experiments with rat models indicate that nesfatin-1 acts as a peripheral modulator of the cardiac function. Much higher levels of serum Nesfatin-1 (up to 160×) were detected in patients with primarily diagnosed epilepsy. During the treatment with anti-epileptics concentration of Nesfatin-1 decreased, but it was still about 10 times higher that the level of the hormone in healthy individuals. It offers the idea that it would be possible to use the Nesfatin-1 as a marker for diagnosis and monitoring of epilepsy.
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