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Index / Biovend / Osteostat Rec. Prot. /Product Detail : RD172111100 Osteostat Rec. Prot.
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Osteostat Rec. Prot.

 Price: 460   EUR
522   USD
356   GBP

Product name : Osteostat Rec. Prot.

Catalog number : RD172111100

Quantity: 0.1 mg

Availability: Yes

Supplier name : Biovend

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Osteostat is the cytokine that binds with TNFRSF18/AITR/GITR. It is important for interactions between activated T-lymphocytes and endothelial cells. It may modulate T-lymphocyte survival in peripheral tissues. Osteostat is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells after stimulation by lipopolysaccha­rides.

 

Osteostat protein is present in human microvascular EC and is highly regulated by IFN-alpha and IFN-beta. Osteostat inhibits differentiation of osteoclasts from monocytic precursor cells. It suppresses the early stage of osteoclastogenesis via inhibition of macrophage factor-induced activator of NF-kappaB (RANK) expression in the osteoclast precursor cells. Osteostat does not inhibit lipopolysaccharide-induced RANK expression in monocytes and dendritic cells, or activation-induced RANK expression in T cells. Osteostat is a novel regulator of osteoclast generation and substantiates the endothelium in bone physiology.

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