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Index / Biovend / Prouroguanylin Rec. Prot. /Product Detail : RD172069100 Prouroguanylin Rec. Prot.
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Prouroguanylin Rec. Prot.

 Price: 460   EUR
522   USD
356   GBP

Product name : Prouroguanylin Rec. Prot.

Catalog number : RD172069100

Quantity: 0.1 mg

Availability: Yes

Supplier name : Biovend

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Prouroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen. Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leasing to elevated blood pressure independent of the level of diatary salt intake. Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids.

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