Product name : S100A12, E.coli Rec. Prot.
Catalog number : RD172221100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
The S100A12 (EN-RAGE, calgranulin) is a member of the S100 protein family, which, in humans, consists of twenty five EF-hand (alpha helix-loop-alpha helix), calcium-binding proteins, mostly in the form of homodimer, heterodimer. The mature S100A12 contains 91 amino acids (Mr 10,444 Da). It is predominantly expressed and secreted by neutrophil granulocytes. It was found in monocytes in small quantities. Hofmann et al. (1999) reported that RAGE is a central cell surface receptor for S100A12 and that they are related members of the S100/calgranulin superfamily. Interaction of EN-RAGE (S100A12) with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggeres cellular activation. In murine models, blockade of EN-RAGE/RAGE quenched delayed-type hypersensitivity and inflammatory colitis by arresting activation of central signaling pathways and expression of inflammatory gene mediators. In regard to its inflammatory properties, S100A12 was already described as promising marker for many diseases in human such as neurodegenerative diseases, atherosclerosis, cancerogenesis, osteoarthritis, familial mediterranean fever and idiopathic pulmonary fibrosis. The plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients.
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