Product name : S100P, E.coli Rec. Prot.
Catalog number : RD172048100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
The S100P has been brain S100 protein originally described as placental protein of about 95 amino acid residues and shares 50% sequence identity α and β.
S100 protein is believed that in the mediation of the intracellular Ca (2), which by binding EF-hand superfamily of calcium (2) binding proteins are involved in modulating (2)-dependent target proteins in a Ca which is a dimer of members is small amount.
It is a dysregulation, DU145, PC3 S100P, androgen-independent prostate cancer cell line LNCaP-R cells it is possible to play a role in the pathogenesis of prostate cancer.
In ductal hyperplasia, rather than infiltrating ductal carcinoma in situ in normal tissues and overexpression of S100P is an important role in imortalization of human mammary epithelial cells progress of tumors in vitro and in vivo play It is early events that may.
In NIH3T3 cells from the culture medium substrate which is performed in the presence of S100P in the culture medium 5, or exposure to chemotherapeutic agents expression S100P - fluorouracil after stripping to increase the survival rate and cell proliferation was enhanced. Purification of addition of S100P the wild type NIH3T3 cells survival effect proliferation and S100P expression to the activation of NF-B and Erks determine the mechanisms dependent in a concentration manner and time be replicated in these involved the effect of the (receptor activity of advanced glycation end products) S100P RAGE activation was correlated, we tested the hypothesis, dass It was found that co-immunoprecipitate S100P with RAGE. In addition, the effect of S100P with RAGE is disturbing, including the administration of the peptide of Amphoterin in that antagonize the activation of RAGE, as is known by the expression of dominant negative RAGE and anti-RAGE antibodies for the survival of cell signaling, proliferation, and was blocked by the drug. These data suggest that there act in an autocrine manner on RAGE that S100P to stimulate cell proliferation and survival.
Our team will respond you as soon as possible !
Kits Elisa; taq POLYMERASE