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Index / Biovend / sPLA2-IIA Rec. Prot. /Product Detail : RD172054100 sPLA2-IIA Rec. Prot.
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sPLA2-IIA Rec. Prot.

 Price: 460   EUR
522   USD
356   GBP

Product name : sPLA2-IIA Rec. Prot.

Catalog number : RD172054100

Quantity: 0.1 mg

Availability: Yes

Supplier name : Biovend

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Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospho­lipids to liberate arachidonic acid (AA. The same reaction also produces lysophosholipids, which represent another class of lipid mediators. 10 isozymes have been identified in the secretory PLA2 (sPLA2) family. It consists of low-molecular weight amd Ca2+, which-requires secretory enzymes that have been implicated in a number of biological processes such as modification of eicosanoid generation, inflammation, and host defense.

This enzyme has been proposed to hydrolyze phosphatidylcholine (PC) in lipoproteins to liberate lyso-PC and free fatty acids in the arterial wall. Thus, facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic fo­ci. sPLA2 expression significantly influences HDL particle size and composition  in mice. it also demonstrates that an induction of sPLA2 is necessary for the decrease in plasma HDL cholesterol in response to inflammatory stimuli. Instillation of bacteria into the bronchi was associated with surfactant degradation and a decrease in large:small ratio of surfactant aggregates in rats.

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