Product name : sPLA2-V Rec. Prot.
Catalog number : RD172081100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA. The same reaction also produces lysophosholipids, which represent another class of lipid mediators. 10 isozymes have been identified in the secretory PLA2 (sPLA2) family. It consists of low-molecular weight amd Ca2+, which-requires secretory enzymes that have been implicated in a number of biological processes such as modification of eicosanoid generation, inflammation, and host defense. This enzyme has been proposed to hydrolyze phosphatidylcholine (PC) in lipoproteins to liberate lyso-PC and free fatty acids in the arterial wall. Thus, facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic foci. sPLA2 expression significantly influences HDL particle size and composition in mice. it also demonstrates that an induction of sPLA2 is necessary for the decrease in plasma HDL cholesterol in response to inflammatory stimuli. Instillation of bacteria into the bronchi was associated with surfactant degradation and a decrease in large:small ratio of surfactant aggregates in rats.
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