Product name : Visfatin Rec. Prot.
Catalog number : RD172098100
Quantity: 0.1 mg
Supplier name : Biovend
Data sheet : Ask more or other datasheet now !
Visfatin is a cytokine that is highly expressed in visceral fat. It was originally isolated as a secreted factor that synergizes with IL-7 and stem cell factors to promote the growth of B cell precursors. Visfatin homologs have been identified in carp, invertebrate mollusks ,bacteria and vertebrates, including humans and mice. It has been postulated to play a role in innate immunity. Visfatin exerts insulin-mimetic effects that are dose-dependent. Such effects are quantitatively similar to those of insulin in stimulating muscle or adipocyte glucose transport and in hampering hepatocyte glucose production. Intravenous injection of recombinant visfatin in mice decreased plasma glucose as the dose increased. Visfatin is as effective as insulin in reducing hyperglycemia in insulin-deficient diabetic mice. Visfatin was also found to be bound to and activate insulin receptor, causing receptor phosphorylation and the activation of downstream signaling molecules. However, visfatin and insulin do not compete for binding to the insulin receptor, indicating that the two proteins were recognized by different regions of the receptor. Thus, visfatin might be related to glucose homeostasis and dysregulation in biosynthesis, signal transduction. It also might contribute to the pathogenesis of diabetes.
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