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Index / Biovend / Cartilage Oligomeric Matrix Protein CHO Rec. Prot. /Product Detail : RGB002 Cartilage Oligomeric Matrix Protein CHO Rec. Prot.
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#RGB002 Cartilage Oligomeric Matrix Protein CHO Rec. Prot.

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  Price : 562   EUR
638   USD
436   GBP
2363   Zloty
75291   JPY
4339   NOK
4649   SEK
636   CHF

Product name : Cartilage Oligomeric Matrix Protein CHO Rec. Prot.

Catalog number : RGB002

Quantity: 0.1 mg

Availability: Yes

Supplier name : Biovend

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Cartilage oligomeric matrix protein (COMP), also designated thrombospondin 5 (TSP 5), is non-collagenous glycoprotein and is a member of the thrombospondin family of extracellular proteins. COMP is a calcium-binding protein of high molecular weight (>500kDa) present in the extracellular matrix of articular, nasal and tracheal cartilage. COMP is not only cartilage-derived but was found widely in other tissues, including synovium and tendon. Intact COMP is pentameric, with five identical subunits and the carboxy-terminal globular domain of native COMP binds to collagens I, II, and IX. It has been proposed that COMP molecules are important for maintaining the properties and integrity of collagen network. In addition COMP may have a storage and delivery function for hydrophobic cellsignaling molecules such as vitamin D. The significance of COMP for normal development and function of cartilage has been underscored by the discovery that mutations of the COMP gene result in pseudoachondro­plasia and some forms of multiple epiphyseal dysplasia. Most published studies have shown that serum levels of COMP provide important information about metabolic changes occurring in the cartilage matrix in joint disease. These studies describe that serum COMP level correlated with cartilage degradation and is a potential prognostic marker in inflammatory joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). Results have demonstrated an association of increasing serum COMP levels with progressive destruction of articular cartilage monitored radiographically. OA and RA are a common disease causing pain and disability in a significant proportion of the adult population and early diagnostics of these diseases is very important for future therapy.

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Pathways :
WP1438: Influenza A virus infection
WP1049: G Protein Signaling Pathways
WP1060: Matrix Metalloproteinases
WP1165: G Protein Signaling Pathways
WP1176: Matrix Metalloproteinases
WP129: Matrix Metalloproteinases
WP1371: G Protein Signaling Pathways
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation

Related Genes :
[COMP] Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5)
[Comp] Cartilage oligomeric matrix protein (COMP)
[COMP] Cartilage oligomeric matrix protein (COMP)
[Comp] Cartilage oligomeric matrix protein (COMP)
[Ucma] Unique cartilage matrix-associated protein (Upper zone of growth plate and cartilage matrix associated protein) [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C) (Gla-rich protein) (GRP)]
[CILP UNQ602/PRO1188] Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2]
[ACAN AGC1 CSPG1 MSK16] Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]
[MMP19 MMP18 RASI] Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18)
[CHI3L1] Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)
[BGN SLRR1A] Biglycan (Bone/cartilage proteoglycan I) (PG-S1)
[CNMD CHMI LECT1] Leukocyte cell-derived chemotaxin 1 (Chondromodulin) (Small cartilage-derived glycoprotein) (SCGP) [Cleaved into: Chondrosurfactant protein (CH-SP); Chondromodulin-1 (Chondromodulin-I) (ChM-I)]
[BGN] Biglycan (Bone/cartilage proteoglycan I) (Leucine-rich PG I) (PG-S1)
[GDF5 BMP14 CDMP1] Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
[Mmp19 Rasi] Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI)
[MMP13] Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Mmp13] Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13)
[COG2 SEC35 YGR120C G6324] Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Protein SEC35)
[ERVK-6 ERVK6] Endogenous retrovirus group K member 6 Rec protein (Central open reading frame) (c-orf) (cORF) (Endogenous retrovirus K protein 6) (HERV-K(C7) Rec protein) (HERV-K(HML-2.HOM) Rec protein) (HERV-K108 Rec protein) (HERV-K_7p22.1 provirus Rec protein) (K-Rev) (Rev-like protein) (Rev/Rex homolog)
[COG1 COD3 SEC36 TFI1 YGL223C] Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Complexed with DOR1 protein 3) (Component of oligomeric Golgi complex 1) (Protein SEC36)
[COG4 COD1 SEC38 SGF1 YPR105C P8283.16] Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Complexed with DOR1 protein 1) (Component of oligomeric Golgi complex 4) (Protein SEC38)
[COG3 GRD20 SEC34 YER157W] Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Protein SEC34)
[ALX1 CART1] ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1)
[Dspp Dmp3] Dentin sialophosphoprotein (Dentin matrix protein 3) (DMP-3) [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)]
[COL2A1] Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]
[FN1 FN] Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
[COG5 GOLTC1 GTC90] Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1)
[ADAMTS12 UNQ1918/PRO4389] A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-)
[MATN3] Matrilin-3
[Alx1 Cart1] ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1)

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