Product name : Sex Hormone-Binding Globulin Rec. Prot.
Catalog number : RGB001
Quantity: 0.1 mg
Supplier name : Biovend
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Sex-hormone-binding globulin (SHBG) is a β-globulin that specifically binds steroid hormones. Its molecular weight is 86 kDa/mol. The hepatocytes is regarded as the major site of SHBG synthesis. Its production is regulated by androgen/estrogen balance, thyroid hormones, insulin and dietary factors, among others. SHBG is involved in the transport of sex steroids in plasma. Its concentration is a major factor regulating their distribution between protein-bound and free states. Determination of SHBG concentration is of chief importance in the evaluation of mild disorders of androgen metabolism. It allows identification of women with hirsutism, who are likely to respond to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and it helps to discriminate between subjects with excessive androgen activity and normal individuals.
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