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Index / Biovis / Caspase-3 Proform, mouse recombinant CASP3 Mouse /Product Detail : 1183P-5 Caspase-3 Proform, mouse recombinant CASP3 Mouse
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#1183P-5 Caspase-3 Proform, mouse recombinant CASP3 Mouse

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  Price : 416   EUR
472   USD
322   GBP
1748   Zloty
55681   JPY
3209   NOK
3438   SEK
470   CHF

Product name : Caspase-3 Proform, mouse recombinant CASP3 Mouse

Catalog number : 1183P-5

Quantity: 5 μg

Availability: Yes

Supplier name : Biovis

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About this Product :

Caspase-3 Proform, mouse recombinant CASP3 Mouse recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. Please read carefully the data sheet of the Caspase-3 Proform, mouse recombinant CASP3 Mouse.
http://mybiofast.com/ver.php?search=rec.&submit=Search

Caspase-3 Proform, mouse recombinant CASP3 Mouse mus musculus murine Caspase-3 Proform, mouse recombinant CASP3 Mouse detects proteins from variouse species most likely human.
http://mybiofast.com/ver.php?search=musculus&submit=Search

More Details about

Alternate Names / Synonyms: Mouse Procaspase-3, Procaspase-3, procaspases, caspase-3 proenzyme, caspase-3 proform

Gene Symbol: CASP3

Accession #: Q8BNT4

Gene ID: 12367

Source: E. coli

Appearance: Lyophilized powder

Physical Form Description: Lyophilized powder

Molecular Weight: 32.0 kDa

Purity by SDS-PAGE: ≥90%

Purity by HPLC: N/A

Endotoxin Level: N/A

Biological Activity: N/A

Reconstitution Instructions: Reconstitute to 0.1 µg/µl in PBS containing 15% glycerol.

Storage Temp.: -70°C

Shipping: gel pack

Background Information: Caspase-3 (also know as CPP32, Yama and apopain) is a member of the caspase family of cysteine proteases. Caspase-3 exists in cells as an inactive 32 kDa proenzyme. Proteolytic processing of this inactive proenzyme generates the 17 kD and 12 kD subunits which, when assembled as a tetramer (a pair of heterodimers), form the active caspase. Cascades of caspase activation have been shown to be key signal-transducing events in apoptosis. Procaspase-3, like other procaspases with short N-terminal prodomains, is considered to be a downstream or “effector” enzyme. Pro-caspase-3 can be cleaved and activated by caspase-8 and –10 which are themselves activated through interaction with death ligand receptor/adapter protein complexes (e.g., Fas/FADD). Procaspase-3 is also processed by caspase-9, the apical caspase that is activated by binding to the Apaf-1/cytochrome c/ATP “apoptosome”. Thus, activation of procaspase-3 stands at a point of convergence for the two major types of apoptosis signaling pathways-those linked to cell surface death receptors and those linked to mitochondrial release of cytochrome c. The recombinant Procaspase-3 (1183P-5) is produced by expression of a human cDNA in E. coli. The purified protein is highly activatable by treatment with active recombinant caspase-8 (1088-25, -100). We routinely test the activation using 10-30 ng of the procaspase-3 treated with 0.1-0.5 units of the active recombinant caspase-8 in 100 µl of Reaction Buffer (1068-20) for 30 minutes. Activation of procaspase-3 can be monitored using the Caspase-3 Fluorometric and Colorimetric Assay Kits (K105 and K106).

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans.

 

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Pathways :
WP1018: Apoptosis
WP1019: FAS pathway and Stress induction of HSP regulation
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1082: Apoptosis Modulation by HSP70
WP1094: IL-6 Signaling Pathway
WP1103: Alpha6-Beta4 Integrin Signaling Pathway
WP1114: MAPK signaling pathway
WP1137: Apoptosis
WP1138: FAS pathway and Stress induction of HSP regulation
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1199: Apoptosis Modulation by HSP70
WP1254: Apoptosis
WP1290: Apoptosis
WP1322: IL-6 Signaling Pathway
WP1329: Alpha6-Beta4 Integrin Signaling Pathway
WP1337: MAPK signaling pathway
WP1348: Androgen Receptor Signaling Pathway
WP135: IL-6 Signaling Pathway
WP1351: Apoptosis
WP1369: TNF-alpha NF-kB Signaling Pathway
WP1392: Apoptosis Modulation by HSP70
WP1496: Oxidative Damage
WP1530: miRNA regulation of DNA Damage Response
WP1579: DNA damage response
WP166: Apoptosis Modulation by HSP70

Related Genes :
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3 At2g27370 F10A12.5 F12K2.5] Casparian strip membrane protein 3 (AtCASP3)
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase 3
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase 3 (Caspase-3-like protein)
[Casp8] Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP3 CR201_G0037886] CASP3 isoform 1 (CASP3 isoform 2) (Caspase 3)
[CASP3] Caspase-3
[CASP3 CK820_G0031735] CASP3 isoform 1 (CASP3 isoform 2) (Caspase 3, apoptosis-related cysteine peptidase)
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Xiap Aipa Api3 Birc4 Miha] E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
[CASP3] Caspase-3
[Gsdme Dfna5 Dfna5h] Gasdermin-E (Non-syndromic hearing impairment protein 5 homolog) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)]
[Birc6 Kiaa1289] Baculoviral IAP repeat-containing protein 6 (EC 2.3.2.27) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (RING-type E3 ubiquitin transferase BIRC6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)
[Atg16l1 Apg16l] Autophagy-related protein 16-1 (APG16-like 1)
[Atcay] Caytaxin
[Bag6 Bat3] Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein Scythe)
[Akap8 Akap95] A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)
[CASP3] Caspase-3
[CASP3 QmoA-14231] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Gsdmdc1 Gsdmd] Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT); Gasdermin-D, C-terminal (GSDMD-CT)]

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