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Index / Biovis / Caspase-3, human recombinant CASP3 Human /Product Detail : 1083-10 Caspase-3, human recombinant CASP3 Human
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  Price : 527   EUR
598   USD
409   GBP
2215   Zloty
70568   JPY
4067   NOK
4358   SEK
596   CHF

Product name : Caspase-3, human recombinant CASP3 Human

Catalog number : 1083-10

Quantity: 10 μg

Availability: Yes

Supplier name : Biovis

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About this Product :

Caspase-3, human recombinant CASP3 Human recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. Please read carefully the data sheet of the Caspase-3, human recombinant CASP3 Human.
http://mybiofast.com/ver.php?search=rec.&submit=Search

Caspase-3, human recombinant CASP3 Human Human samples 80 % of the research is conducted on human samples. Gentaur suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Caspase-3, human recombinant CASP3 Human.
http://mybiofast.com/ver.php?search=human+&submit=Search

More Details about

FORM: Lyophilized powder
RECONSTITUTION: Reconstitute in PBS containing 15% glycerol.


STORAGE CONDITIONS:
The lyophilized caspase-3 is stable for 1 year at –70°C. Following reconstitution in PBS, the enzyme should be aliquoted and immediately stored at –70°C. Avoid multiple freeze/thaw cycles as activity might decrease.


DESCRIPTION:
Caspase-3 (also know as CPP32, Yama and apopain) is a major member of the caspasefamily of cysteine proteases. Caspase-3 exists in cells as an inactive 32 kDa proenzyme.
During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. The processed form of caspase-3 consists of large (17 kD) and small (11 kD) subunits which associate to form the active enzyme. The active caspase-3 has been shown involving in the proteolysis of several important molecules, such as poly (ADP-ribose) polymerase (PARP), the sterol regulatory element binding proteins (SREBPs), focal adhesion kinase (FAK), and others. The recombinant active human caspase-3 expressed in E. coli spontaneously undergoes autoprocessing to yield subunits characteristic of the native enzyme (Full length gene Accession No. NP_004337) . The active caspase-3 preferentially cleaves caspase-3 substrates (e.g., DEVD-AFC or DEVD-pNA) and is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-DEVD-pNA (Cat.#1008-200) or Ac-DEVD-AFC (1007-200).


APPLICATIONS AND USAGE:
Active caspase-3 is useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays and Western blot analysis.
For a complete caspase-3 assay protocol, please refer to BioVision’s Caspase-3/CPP32 Fluorometric or Colorimetric Assay Kits (Cat.#: K105 and K106).


For Research Use Only! Not to be used in humans.

 

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Pathways :
WP1322: IL-6 Signaling Pathway
WP1530: miRNA regulation of DNA Damage Response
WP1772: Apoptosis Modulation and Signaling
WP2087: miRNA regulation of DNA Damage Response
WP2107: pathways in human cancer
WP387: IL-6 signaling Pathway
WP100: Glutathione metabolism
WP1018: Apoptosis
WP1019: FAS pathway and Stress induction of HSP regulation
WP1039: Glutathione metabolism
WP104: Alanine and aspartate metabolism
WP1047: TNF-alpha NF-kB Signaling Pathway
WP106: Alanine and aspartate metabolism
WP1082: Apoptosis Modulation by HSP70
WP1094: IL-6 Signaling Pathway
WP1103: Alpha6-Beta4 Integrin Signaling Pathway
WP1114: MAPK signaling pathway
WP1126: Tryptophan metabolism
WP1137: Apoptosis
WP1138: FAS pathway and Stress induction of HSP regulation
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1199: Apoptosis Modulation by HSP70
WP1254: Apoptosis
WP1290: Apoptosis
WP1329: Alpha6-Beta4 Integrin Signaling Pathway

Related Genes :
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase 3
[CASP3 At2g27370 F10A12.5 F12K2.5] Casparian strip membrane protein 3 (AtCASP3)
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase 3 (Caspase-3-like protein)
[CASP3 CR201_G0037886] CASP3 isoform 1 (CASP3 isoform 2) (Caspase 3)
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP3] Caspase-3
[CASP3 CK820_G0031735] CASP3 isoform 1 (CASP3 isoform 2) (Caspase 3, apoptosis-related cysteine peptidase)
[CASP3] Caspase-3
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP9 MCH6] Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
[CASP6 MCH2] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[CASP3 QmoA-14231] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[TXN TRDX TRX TRX1] Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP)
[CASP3] Caspase-3
[XIAP API3 BIRC4 IAP3] E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
[CASP3] Caspase 3
[ATG4D APG4D AUTL4] Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagin-4) (Autophagy-related cysteine endopeptidase 4) (Autophagy-related protein 4 homolog D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]
[CASP3] Caspase-3
[CASP3] Caspase 3

Bibliography :
[30890748] Molecular characterization and antiapoptotic function analysis of the duck plague virus Us5 gene.
[30890499] [Targeted binding of estradiol with ESR1 promotes proliferation of human chondrocytes by inhibiting activation of ERK signaling pathway].
[30884582] [Construction of 3β-HSD gene silencing cell line and its effects on apoptosis induced by DEHP].
[30850949] Manilkara zapota (L.) P. Royen Leaf Extract Derived Silver Nanoparticles Induce Apoptosis in Human Colorectal Carcinoma Cells Without Affecting Human Lymphocytes or Erythrocytes.
[30841517] Recombinant Human Superoxide Dismutase and -Acetylcysteine Addition to Exogenous Surfactant in the Treatment of Meconium Aspiration Syndrome.
[30798161] Modification of IL-24 by tumor penetrating peptide iRGD enhanced its antitumor efficacy against non-small cell lung cancer.
[30794682] Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis.
[30786815] Activation of CD3 T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma.
[30767429] Tumor necrosis factor-related apoptosis inducing ligand induces apoptosis in canine hemangiosarcoma cells in vitro.
[30718467] Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic-ischemic encephalopathy.